Histological Evaluation of Bone Regeneration Means Freeze Dried Bone Allograft (FDBA) in Post Exodontia Sockets

Abstract

SUMMARY:Within oral rehabilitation alveolar ridge preservation following extraction is important. This research study shows a histological, histochemical and histomorphometrical evaluation in two cases of post extraction ridge-socket preservation performed with FDBA. In two patients dental extraction procedures were performed and sockets were immediately filled with FDBA. Six months later a biopsy of grafted area was obtained and rehabilitated through dental implant. Grafted bone samples were treated for histological and histochemical analysis. Bone tissue area was measured. Laboratory analysis of three samples showed inactive bone surfaces, neither osteoblasts nor osteoclasts were found, only osteocyte and osteogenous cells were observed. These findings do not mean that tissue is metabolically inactive, rather bone genesis develop from a tissue matrix with the potential to generate undifferentiated osteocytes, and a micro environment with proteins such as bone morphogenetic proteins (BPM). Inactive biomaterial particles were not observed. Samples showed 0% and 30% bone tissue respectively. Considering histological differences between this and other research studies, it is necessary to develop further investigation to increase knowledge of processes involved in bone regeneration as well as bone quality, considering the variability that could be seen in each patient.

The Behavior of Demineralized Bone Matrix (DBM) in Post-Extraction Sockets

“…Its suggested that DBM acts as a better bone graft than Freeze Dried Bone Allogaft, compared with the results for the FDBA by Fuentes et al (2011), when only collagen fibers type I were found in the sample.…”

Evaluation of the Osteogenic Potential of Growth Factor–Rich Demineralized Bone Matrix In Vivo

“…Bone grafts have been widely used to aid in the reconstruction of osseous dentoalveolar defects as well as atrophic alveolar ridge augmentation before implant placement 1,2 . These range from autogenous bone grafts (ABGs) and allografts to xenografts and alloplast or synthetic graft materials 3 .…”