Histological Changes in Muscles During the Lower Extremities Thrombosis in Individuals with Gastrointestinal Tract Cancer

Abstract

Thrombosis is a common complication in cancer patients. In all cancer patients, changes occur that lead to arterial and venous thrombosis. It is not known for certain what exactly provokes the appearance of blood clots and causes disseminated intravascular coagulation (DIC). A morpho-histological study of the muscles of the lower extremities was carried out in two groups of people who suffered from cancer and had deep vein thrombosis of the lower extremities with subsequent migration of blood clots. In two groups of people who died due to the migration of blood clots from the veins of the lower extremities in the pulmonary artery, clear dystrophic changes in muscle fibers were found with narrowing of all arterioles and a strong expansion of the venous vessels. In all the venous vessels of the preparation, damage to the endothelium was found, which may indicate the presence of thrombosis of the venous vessels carrying blood from the muscles. People with cancer of the pancreas and/or colon have significant hemodynamic, hypertrophic, dystrophic, and atrophic changes in muscle fibers. There are signs of a systemic effect of the tumor on the vessels and hemodynamics in the lower extremities.

Comparative Study of Surgical Treatment with Abdominal and Perineal Approaches in Patients with Rectal Prolapse

“…The development of RP is caused by the presence of an abnormally deep Douglas space (Petros, 2018;Petros, 2022), weakness of the pelvic floor and anal canal due to muscle atrophy (Amiri et al, 2015;Madbouly & Mohii, 2019;Moubarez et al, 2019;Bodnar et al, 2021), weakness of the internal and external sphincter muscles, neuropathy of the pudendal nerve (Jorge et al, 2022) and the absence of normal rectum fixation (Alketbi et al, 2021), with mobile mesorectum and weak lateral ligaments (Joubert & Laryea, 2017). In this case, the mobile small intestine, which lies opposite the anterior wall of the rectum, can push it out through the anal canal.…”

Review on Diagnosis and Management of Colorectal Carcinoma

“…Colorectal carcinoma is formed in the colon instead of the rectum, where rectal cancer starts. [1,2] Colorectal cancer is a term used to describe cancers that affect either of these organs. While not always the case, most colorectal malignancies often arise from adenomatous (precancerous) polyps over time, [3] where after some mutations or abnormalities occur in their cellular DNA, polyps/growths might change.…”