Histological and toxicological responses of the mummichog, Fundulus Heteroclitus (L.) to combinations of levels of cadmium and dissolved oxygen in a freshwater

Voyer, R.A.; Yevich, Paul P.; Barszcz, Carolyn A.

doi:10.1016/0043-1354(75)90103-7

Cited by 24 publications

(11 citation statements)

References 16 publications

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“…This in turn retarded the rate of maturation and production of testosterone and 11 -ketotestosterorie. Mummichog exposed to 28 mg Cd L -I showed necrosis and sloughing of mucosa of respiratory epithelium of gill filaments and lamellae (Voyer et al, 1975). This accounts for the decrease in oxygen consumption and increase in ventilation frequency in chronically exposed fish.…”

Section: Fishmentioning

confidence: 93%

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Heavy Metals in Natural Waters

Moore

Ramamoorthy

1984

Springer Series on Environmental Management

521

183

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Section: Fishmentioning

confidence: 93%

“…Although low dissolved oxygen levels probably increase toxicity to many species, Voyer et al (1975) reported that survival of mummichog was similar regardless of oxygen concentration within the range of 3.5 to 9.4 mg L-I.…”

Section: Fishmentioning

confidence: 99%

Heavy Metals in Natural Waters

Moore

Ramamoorthy

1984

Springer Series on Environmental Management

521

183

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“…Gill damage and structural changes caused by water-borne cadmium have been reported for several fish species (Bilinski and Jones, 1973;Eisler and Gardner, 1973;Gardner and Yevich, 1970;Voyer et al, 1975;Karlsson-Norrgren et al, 1985). Simi lar alterations of the gills have been observed in fish exposed to other toxic metals such as mercury (Lock et al, 1981;Naidu et al, 1983), copper (Gupta and Rajbanshi, 1981), zinc (Crespo et al, 1981), chromium (Van de Putte et al, 1982), tributyltin (Pinkey et al, 1989) and, in acidic waters, aluminium (Youson and Neville, 1987).…”

Section: Introductionmentioning

confidence: 99%

Effect of ambient and dietary cadmium on pavement cells, chloride cells, and Na+/K+-ATPase activity in the gills of the freshwater teleost Oreochromis mossambicus at normal and high calcium levels in the ambient water

1993

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The effects of cadmium on the gills of the African freshwater cichlid Oreochromis mossambicus in water with normal and relatively high calcium concentrations were studied for periods up to 35 days. The expo sure was either through the ambient water or via the diet. Changes in the ultrastructure of the gill epitheli um upon exposure to cadmium in the ambient water indicated degeneration of pavement cells and chloride cells, and acceleration in the turnover of the chloride cells. Studies of the Na7K/-ATPase activity of the gills indicated that a transient increase in the total number of chloride cells was not associated with an increase, but rather a decrease of the total ion-exchange capacity of the chloride cells. Macrophages, lymphocytes, rodlet cells and neutrophilic granulocytes infiltrated the filament epithelium. Recovery of the gills was observed after 35 days. Dietary cadmium caused similar, although delayed, effects. High water calcium concentration reduced the impact of water-borne cadmium, but had no ameliorating effect on dietary cadmium. The data indicate that the disturbance of ion regulation in fish caused by sublethal levels of dietary cadmium is the result of effects of the metals on the gills rather than on the kidney.

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“…Histopathology provides an anatomic basis for the effects of cadmium toxicity. The best studies have described the pathological lesions in marine and estuarine fishes to acute, natural exposure of high concentrations of cadmium salts (Gardner and Yevich, 1970;Newman and MacLean, 1974;Voyer et al, 1975). Comparable studies utilizing freshwater species have not been performed.…”

Section: Introductionmentioning

confidence: 97%

“…These studies have shown that cadmium is quite toxic to many species of fishes when exposed in high concentrations. Only a few studies, however, have utilized histopathological evaluation of fish as a method of toxicologic assessment (Gardner and Yevich, 1970;Hawkins et al, 1980;Newman and MacLean, 1974;Tafanelli and Summerfelt, 1975;Voyer et al, 1975). Histopathology provides an anatomic basis for the effects of cadmium toxicity.…”

Section: Introductionmentioning

confidence: 98%

Pathology of lethal and sublethal exposure of fathead minnows,pimephales promelas, to cadmium: A model for aquatic toxicity assessment

Stromberg¹,

Ferrante²,

Carter³

1983

Journal of Toxicology and Environmental Health

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Seventy-six fathead minnows were exposed to 12 ppm cadmium for 96-h and examined histologically at 1-wk intervals for 30 d. Thirteen fish (17.1%) died during the exposure period. Lesions associated with acute cadmium toxicity were epithelial necrosis of the skin, oral cavity, gills, olfactory organs, kidney, urinary bladder, ureters, gastrointestinal tract, and hemopoietic organ. The lesions were most severe in fish which died. Survivors had similar but less severe and less extensive lesions. Residual minimal to mild multifocal necrosis was observed In gastrointestinal, branchial epithelium and and hemopoietic tissue up to 29 d postexposure. Radiotracer studies in 50 fish using 115 Cd demonstrated a rapid uptake and two phase elimination of cadmium by the fish. Rapid elimination of cadmium occurred within 7 wk and was correlated with lesions in the urinary epithelium. Slow phase elimination occurred for at least 3 wk and was correlated with persistant minimal necrosis in several tissues.

show abstract

Histological and toxicological responses of the mummichog, Fundulus Heteroclitus (L.) to combinations of levels of cadmium and dissolved oxygen in a freshwater

Cited by 24 publications

References 16 publications

Heavy Metals in Natural Waters

Heavy Metals in Natural Waters

Effect of ambient and dietary cadmium on pavement cells, chloride cells, and Na+/K+-ATPase activity in the gills of the freshwater teleost Oreochromis mossambicus at normal and high calcium levels in the ambient water

Pathology of lethal and sublethal exposure of fathead minnows,pimephales promelas, to cadmium: A model for aquatic toxicity assessment

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