Seventy-six fathead minnows were exposed to 12 ppm cadmium for 96-h and examined histologically at 1-wk intervals for 30 d. Thirteen fish (17.1%) died during the exposure period. Lesions associated with acute cadmium toxicity were epithelial necrosis of the skin, oral cavity, gills, olfactory organs, kidney, urinary bladder, ureters, gastrointestinal tract, and hemopoietic organ. The lesions were most severe in fish which died. Survivors had similar but less severe and less extensive lesions. Residual minimal to mild multifocal necrosis was observed In gastrointestinal, branchial epithelium and and hemopoietic tissue up to 29 d postexposure. Radiotracer studies in 50 fish using 115 Cd demonstrated a rapid uptake and two phase elimination of cadmium by the fish. Rapid elimination of cadmium occurred within 7 wk and was correlated with lesions in the urinary epithelium. Slow phase elimination occurred for at least 3 wk and was correlated with persistant minimal necrosis in several tissues.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.