Histologic and biomolecular aspects of papillomatosis of the vulvar vestibule in relation to human papillomavirus

Jm, de Deus; Focchi, José; Jn, Stávale; Gr, de Lima

doi:10.1016/0029-7844(95)00271-r

Cited by 21 publications

(16 citation statements)

References 17 publications

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“…Early reports suggested that human papilloma virus (HPV) plays a major role in the pathogenesis of vulvar vestibulitis [50]. However, this could not be confirmed by studies using molecular techniques [51,52]. Vulvodynia associated with HPV DNA is clinically identical to vulvodynia without HPV DNA, suggesting that HPV does not cause vulvodynia [53].…”

Section: Vulvodyniamentioning

confidence: 89%

Pain of urogenital origin

Wesselmann

Czakanski

1999

Current Review of Pain

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This review highlights the clinical presentation of common pain syndromes of urogenital origin (including testicular pain, prostatitis, prostatodynia, penile pain, vulvodynia, clitoral pain, urethral syndrome, and perineal pain) and discusses pain management options.Chronic pain of urogenital origin is a common and debilitating problem that can significantly impair the quality of life of the patient. Patients with these pain syndromes often suffer for many years, have seen numerous physicians in numerous subspecialties, and are frustrated and embarrassed. They are usually evaluated and treated by urologists, gynecologists, gastroenterologists, and internists. In many cases the focus is on finding and treating the underlying etiology of the chronic pain syndrome, and these patients often undergo many diagnostic tests and procedures. However, often the examination and work-up remain unrevealing, and no specific cause of the pain can be identified. Although these patients are often depressed, rarely are these pain syndromes the only manifestation of a psychiatric disease. In these cases it is important to recognize that the patient is suffering from a chronic pain syndrome and to direct treatment strategies towards symptomatic pain management. Despite the challenge inherent in the management of chronic urogenital pain, many patients can be treated successfully. Our focus is on chronic nonmalignant urogenital pain syndromes. Another very important topic is the management of chronic pain syndromes associated with cancer of the urogenital tract, and the reader is referred to excellent reviews on cancer pain management [1]. The present article is intended to first give a brief overview of the current knowledge of the neurobiology of the urogenital tract, and then to review the clinical presentations, etiologies, differential diagnoses, and treatment options of chronic pain syndromes of urogenital origin. Neurobiology of the Urogenital TractThe urogenital tract is a highly specialized area of the body, responsible for carrying out a host of basic biologic functions including micturition, copulation, and reproduction. The display of these diverse functions relies on precise nervous system control, coordinated with endocrine and other local control mechanisms. The complexity of this network has largely been considered to account for the slow progress in our understanding of the neurobiology of the urogenital tract as compared to other areas of the body. In addition, these areas of the body are often considered taboo in our society, and this might be another reason why there has been fairly little neuroanatomic, neurophysiologic, and neuropharmacologic research in this area. This article gives a condensed overview of urogenital neurobiology, targeted towards the physician who is evaluating and treating patients with chronic urogenital pain, and for whom a basic understanding of the neurobiology of the urogenital tract is important. A detailed review of the neurobiology of the pelvis perineum is provided in Wesselmann et al....

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Section: Vulvodyniamentioning

confidence: 89%

Pain of urogenital origin

Wesselmann

Czakanski

1999

Current Review of Pain

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“…This condition is characterized by multiple millimetric papillae of the vestibule and lower third of labia minora. This entity is a normal anatomical variant of the vulva but is commonly mistaken for human papillomavirus (HPV) condyloma [15]. In a prevalence study performed in the UK, 1% of women showed vestibular papillomatosis, although other authors have found the prevalence to range between 5.1% and 33%.…”

Section: Vestibular Papillomatosismentioning

confidence: 96%

Benign vulvar tumors

Maldonado

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

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“…Neben den typischen blumenkohlartigen Kondylomen findet man bei den betroffenen kleinen Mädchen das Bild der Vulvapapillomatose: kleine Papillen,bevorzugt im Bereich des Vestibulums und periurethral, die grundsätzlich als paraphysiologische Formation des Vulvaepithels angesehen werden müssen, und in denen nur in 6% HPV-DNA nachgewiesen werden kann [5]. Neben den typischen blumenkohlartigen Kondylomen findet man bei den betroffenen kleinen Mädchen das Bild der Vulvapapillomatose: kleine Papillen,bevorzugt im Bereich des Vestibulums und periurethral, die grundsätzlich als paraphysiologische Formation des Vulvaepithels angesehen werden müssen, und in denen nur in 6% HPV-DNA nachgewiesen werden kann [5].…”

Section: Genitale Hpv-läsion Im Kindes-und Jugendalterunclassified

Vulvar disorders in childhood and adolescence

Wachter

2001

Der Gynäkologe

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Histologic and biomolecular aspects of papillomatosis of the vulvar vestibule in relation to human papillomavirus

Cited by 21 publications

References 17 publications

Pain of urogenital origin

Pain of urogenital origin

Benign vulvar tumors

Vulvar disorders in childhood and adolescence

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