Histocytology of Lymphoid Tumors in the Dog, Cat and Cow

Valli, V. E.; McSherry, B. J.; Dunham, Barbara; Jacobs, Robert M.; Lumsden, J. H.

doi:10.1177/030098588101800408

Cited by 37 publications

(21 citation statements)

References 12 publications

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“…Several studies on canine NHL indicate a breed predilection, which suggests the existence of a genetic predisposition 23,24 . The Boxer is frequently noted among predisposed breeds 24–26 . Our study also demonstrates a breed association with lymphomas for the Boxer, Setter, Cocker Spaniel ( P < .001), and probably the Rottweiler and Beauce Shepherd dog (not confirmed statistically).…”

Section: Discussionsupporting

confidence: 54%

Genetic and Environmental Risk Indicators in Canine Non‐Hodgkin's Lymphomas: Breed Associations and Geographic Distribution of 608 Cases Diagnosed throughout France over 1 Year

Pastor

Chalvet‐Monfray

Marchal

et al. 2009

Veterinary Internal Medicne

106

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Background: The etiology of non-Hodgkin's lymphomas (NHL) is multifactorial. Environmental and genetic factors are frequently incriminated both in humans and dogs.Objectives: Our purpose was to study the geographic distribution of canine NHL (CNHL) in France and to evaluate genetic and environmental influences.Animals: Six hundred and eight cases of CNHL, diagnosed throughout France over 1 year, were collected from 7 Veterinary Histopathologic Laboratories.Methods: Retrospective study. Breeds affected by lymphomas were compared with the national population and associations between breed and immunophenotype were studied. The distribution of CNHL and canine T-cell NHL per 100,000 dogs per department was compared with the distribution of waste incinerators, polluted sites, and radioactive waste.Results: The breeds significantly overrepresented among lymphoma cases were Boxer, Setter, and Cocker Spaniel (P o .001). There was a significant association between Boxer and T-cell NHL (P o .001), and between German Shepherd and Rottweiler and B-cell NHL (P o .01). The geographic distribution of CNHL and canine T-cell NHL indicated significant heterogeneity. Significant association between distributions of CNHL and waste incinerators (r 5 0.25, P o .05), polluted sites (r 5 0.36, P o .001), and radioactive waste (r 5 0.51, P o .001) was found.Conclusions and Clinical Importance: Influence of genetics in the development of CNHL was supported by the existence of an association between breed and immunophenotype. Waste incinerators, polluted sites, and radioactive waste could just be considered as risk indicators of CNHL, but not as risk factors. Case-control studies around critical sites are necessary to confirm the implication of those environmental factors in the development of CNHL.

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Section: Discussionsupporting

confidence: 54%

Genetic and Environmental Risk Indicators in Canine Non‐Hodgkin's Lymphomas: Breed Associations and Geographic Distribution of 608 Cases Diagnosed throughout France over 1 Year

Pastor

Chalvet‐Monfray

Marchal

et al. 2009

Veterinary Internal Medicne

106

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“…4 , 1 2 , 1 3 Un f o rt u n a t e l y, a va r i e t y of classification systems have been used, with most being modifications or direct applications of systems developed for human patients. [13][14][15][16][17] The merits of these classification systems are questionable and this has caused some inconsistencies in the ve t e r i n a ry studies undertaken to date.…”

Section: Felvmentioning

confidence: 99%

Immunophenotypic and histological characterisation of 109 cases of feline lymphosarcoma

1999

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Objective To determine and analyse the immunophenotype and histological appearance of naturally occurring cases of lymphosarcoma in Australian cats. Design A prospective multi‐institutional study of naturally occurring feline lymphosarcoma. Methods One hundred and eighteen cats were referred for diagnosis and/or management of suspected lymphosarcoma. Tissue samples for histopathological analysis and immunophenotyping were collected as biopsies or at necropsy from 109 cases. Histological classification of the neoplasms followed the Working Formulation Classification System. Four multi‐species cross‐reactive antibodies were used to classify tumours as having a B or T cell phenotype. Results Seventy‐six (70%) cases were B cell tumours and 28 (26%) were T cell tumours. The remaining 5 (4%) specimens failed to stain with the four antibodies. Histologically, 11 (10%) cases were classified as low‐grade, 72 (66%) were medium‐grade and 26 (24%) were high‐grade tumours. There were no significant associations between age and either histological grade or immunophenotype. Mediastinal and leukaemic cases were significantly more likely to be T cell tumours (P < 0.001 and P < 0.001, respectively). Conclusions In contrast to previously documented studies in the cat, the majority of cases of lymphosarcoma were of B cell phenotype and intermediate histological grade. Based on our data, the histological phenotype of lymphosarcoma is unlikely to predict immunotype, nor are cases of certain immunotypes likely to be of specific histological subtype. Considered in relation to previous reports, the findings suggest that epidemiological factors operating in these cats to produce lymphosarcoma may be different to those operating in North American and UK cat populations.

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“…12,13 In domestic animals they have been classified on the basis of anatomical distribution 14,15 and cell morphology. 16 Immunophenotyping provides addi-tional information for classification. Markers specific for T and B cell subsets have been utilised for immunohistochemical analysis of tissue sections and flow cytometry of cell suspensions.…”

mentioning

confidence: 99%