HISTOCHEMICAL STUDIES ON THE ADRENAL MEDULLARY CELLS OF THE MARMOSET (CALLITHRIX JACCHUS)

Miraglia, Tulio

doi:10.1177/13.7.595

Cited by 5 publications

(3 citation statements)

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“…The uniform enzymatic reaction of the medullary cells can be explained if we bear in mind that they belong exclusively to the adrenaline-releasing type, as was demonstrated by Miraglia [1965]. Conversely, the cells of the cortical part show a different zonal reactivity.…”

Section: Commentsmentioning

confidence: 79%

“…Received: July 29, 1974. Some points on the histochemistry of the adrenal medulla [Miraglia, 1965] and adrenal cortex [Miraglia and Moreira, 1969] of adult C. jacchus were already considered. In the present work we studied the distribution of a large number of enzymes, mainly dehydro genases, in the adrenal glands of adult marmosets (C.jacchus and C.penicillata).…”

Section: Introductionmentioning

confidence: 99%

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Histochemical studies on the adrenal glands of the marmosets (Callithrix jacchus and Callithrix penicillata)

Miraglia¹,

Sadigursky²,

Roters³

et al. 1976

Cells Tissues Organs

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The histrochemistry of the adrenal glands was studied in four adult male marmosets (two Callithrix jacchus and two Callithrix penicillata). It was impossible to demonstrate any reactivity to UDPG-GT, ADH, alanyl aminopeptidase, leucine amino-peptidase, xilitol (NAD-dependent) dehydrogenase, β-glucuronidase and aryl-sulfatase in these glands. Total phosphorylase was found in scattered cells of the glomerulosa and adjacent outer fasciculata of one C. penicillata. The dehydrogenases (LDH, G-6-PDH, 6-PGDH, NADH₂-TR, ICDH, SDH, NADH₂-TR, α-GPDH, β-OHBDH) as well as the hydrolases (except alkaline phosphatase, ATPase, and acetylcholinesterase) showed a stronger reactivity in the cortical part. Some hydrolases (naphthol acetate esterase, acid phosphatase) and cytochrome oxidase were less reactive in the zona glomerulosa, where the dehydrogenases were more abundant. The outer fasciculata and the reticularis also showed a strong dehydrogenase reactivity.

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Section: Commentsmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Histochemical studies on the adrenal glands of the marmosets (Callithrix jacchus and Callithrix penicillata)

Miraglia¹,

Sadigursky²,

Roters³

et al. 1976

Cells Tissues Organs

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“…Miraglia & Moreira (1969) found morphological evidence for the presence of a ZR in marmosets, yet nonimmunospecific staining methods were used and the result was subsequently debated. Levine et al (1982) utilized hematoxylin and eosin staining in neonatal, infant, and adult adrenals and showed a morphologically distinct inner adrenal area at birth that regressed completely by three months of age and did not reappear upon sexual maturity at 18-21 months.…”

Section: The Marmoset Adrenalmentioning

confidence: 99%

Plasticity of the zona reticularis in the adult marmoset adrenal cortex: voyages of discovery in the New World

Pattison¹,

Abbott²,

Saltzman³

et al. 2009

Journal of Endocrinology

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Adrenarche in humans occurs at the age of 5-7 years, yet the process by which dehydroepiandrosterone (DHEA) biosynthesis in the adrenal zona reticularis (ZR) increases so dramatically remains as a matter of debate. One suggestion is that increased DHEA production by P450c17 (CYP17A1 as listed in HUGO Database) in the ZR results from a coincident fall in the expression of HSD3B, which would otherwise compete for pregnenolone substrate. Nonetheless, studies of human and rhesus adrenal show that cytochrome b5 (CYTB5) expression increases in the ZR with DHEA biosynthesis, and cloned human and rhesus P450c17 show selective increases in 17,20-lyase activity in the presence of CYTB5. The marmoset, a New World primate, expresses a fetal zone during development which regresses after birth. Adult males, however, do not develop an obvious functional ZR, while females develop a ZR in a manner that depends on their social/gonadal status. In all social and physiologic states, changes in marmoset ZR function relate directly to changes in the expression of CYTB5. Recent cloning and expression of marmoset P450c17 also show that while amino acid sequence homology is in the order of w85% of that found in human and rhesus sequences, and basal lyase activity is low compared with rhesus, all previously described amino acids critical to human 17,20-lyase activity are completely conserved. Furthermore, the 17,20-lyase activity of the marmoset P450c17 clone is dramatically increased by addition of CYTB5. We propose that these combined data from the marmoset model provide further compelling evidence that the control of ZR CYTB5 expression is a key determinant of ZR function.

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The Adrenal Gland

Arvy

1971

Histoenzymology of the Endocrine Glands

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HISTOCHEMICAL STUDIES ON THE ADRENAL MEDULLARY CELLS OF THE MARMOSET (CALLITHRIX JACCHUS)

Cited by 5 publications

References 0 publications

Histochemical studies on the adrenal glands of the marmosets (<i>Callithrix jacchus</i> and <i>Callithrix penicillata</i>)

Histochemical studies on the adrenal glands of the marmosets (<i>Callithrix jacchus</i> and <i>Callithrix penicillata</i>)

Plasticity of the zona reticularis in the adult marmoset adrenal cortex: voyages of discovery in the New World

The Adrenal Gland

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