Histamine H2-Receptor Antagonists in Peptic Ulcer Disease

Abstract

The H2-receptor antagonists have undoubtably been successful in healing primary gastric and duodenal ulcers so there is a tendency to assume that they will be equally successful when used as prophylactic agents. When used to prevent gastroduodenal ulceration induced by nonsteroidal anti-inflammatory agents, they are unsuccessful in protecting against gastric damage, but reduce the incidence of duodenal ulceration. However, their effect on the incidence of serious complications remains unknown. In the prevention of stress ulceration and bleeding in intensive care units there is evidence of a beneficial effect of H2-receptor antagonists, but other agents are also equally effective. In patients who present with haematemesis and melaena, there is little evidence to show that H2-receptor antagonists reduce rates of transfusion or surgical intervention, or decrease mortality.

Antiulcer activity of the chloroform extract ofBauhinia purpurealeaf

“…Gastric ulcer affects a large portion of the human population and is caused by several factors such as ingestion of nonsteroidal antiinflammatory drugs (NSAIDs), stress, smoking, and nutritional deficiencies (Nash et al, 1994). The pathophysiology of this disorder has focused on the imbalance between aggressive and protective factors in the stomach including acid-pepsin secretion, mucosal barrier, mucus secretion, blood flow, cellular regeneration, prostaglandins, and epidermal growth factors .…”

Anti-gastric Actions of Eugenol and Cinnamic Acid Isolated from Cinnamomi Ramulus

“…5) Gastric diseases including gastric ulcer, infection of H. pylori, gastritis, and gastric cancer aŠected a large portion of the world population and are induced by several factors, such as stress, smoking, nutritional deˆciencies, and ingestion of nonsteroidal anti-in‰ammatory drugs. 6) Peptic ulcers appear to result from overproduction of gastric acid and or decrease on gastric mucosal protective mechanisms. Consequently, reduction of gastric acid production as well as reinforcement of gastric mucosal protection has been main approaches for peptic ulcer therapy.…”

Gastroprotective effects of Stachys Lavandulifolia extract on experimental gastric ulcer

“…Many factors are involved in gastric and duodenal ulcer pathology such as stress, smoking, nutritional deficiencies, alcohol ingestion and nonsteroidal anti-inflammatory drugs (Nash et al, 1994;Basil and Howard, 1995). Protective measures should focus on gastric muco-sa integrity and affect acid-pepsin secretion, parietal cell activity, mucosal barrier, mucus secretion, blood flow, cell regeneration, and endogenous protective agents especially nitric oxide (Singha et al, 2008).…”