Several studies have used Stachys Lavandulifolia vahl (S. lavandulifolia) as medicinal plant in Iranian folk medicine. The present investigation is designed to elucidate therapeutic and preventive effects of S. lavandulifolia extract on gastric acid and pepsin secretions in experimental gastric ulcer. Thirty two Wistar male rats were used to study therapeutic and preventive effects of S. lavandulifolia extract on alcohol-induced gastric ulcer. Animals were equally (n=8) divided into 4 groups: (I) Control (II) Alcohol (1 ml/200 g/bw) to induce gastric ulcer (III) Alcohol/Lvandu (100 mg/kg bw/daily, S. lavandulifolia extract was given for two weeks post alcohol administration) and (IV) Lvandu/alcohol (S. lavandulifolia extract was given for two weeks before alcohol administration). Ulcer index, gastric acid and pepsin secretions was measured. Ulcer index was significantly decreased in alcohol/Lvandu than Alcohol group. Also gastric acid and pepsin secretions, and gastric tissue's NO metabolites level were significantly lower in alcohol and Lvandu/alcohol groups than control (p<0/05). But changes in gastric acid and pepsin secretions have not been noticeable in alcohol/Lvandu group than control. The results of this study show that S. lavandulifolia extract protected gastric mucosa from alcohol-induced gastric ulcer. This gastroprotection may mediate via gastric mucosal nitric oxide production.
Reflux esophagitis is a common gastrointestinal disorder that affects the quality of life in patients.Esophagitis is a chronic disease that leads to inflammation of the esophagus. Ghrelin is a 28-amino acid peptide that has several endocrine and metabolic effects. The aim of this study was to investigate the effect of ghrelin on the esophagitis. Eighteen wistar rats were divided into three groups of six. Midline laparatomy was performed in the control group. In the gastroesophageal reflux disease (GERD) and GERD+Ghrelin groups, esophagitis was induced by method of Omura. Rats in GERD+Ghrelin group received 4 i.p. injections of 25 ng/g body weight ghrelin. The amount of gastric acid secretion and esophageal blood flow were measured. Gastric acid in GERD+Ghrelin group increased significantly when compared to control and GERD groups. The epithelium thickness and papillae of lamina properia length in GERD group increased significantly compared to the control group. The difference in papillae of lamina properia length between GERD and GERD+Ghrelin was statistically significant. Esophageal blood flow in GERD+Ghrelin group increased significantly in comparison with GERD group. Treatment with ghrelin could reduce esophageal mucosal damage followed by chronic exposure of acid and other gastric contents.
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