Hispolon, a yellow pigment from Inonotus hispidus

Ali, Nasser A. Awadh; Jansen, Rolf; Pilgrim, H; Liberra, K.; Lindequist, Ulrike

doi:10.1016/0031-9422(95)00717-2

Cited by 69 publications

(8 citation statements)

References 6 publications

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“…Despite culture notes stating that S. cuboideum produced yellow stain in culture, no yellow was detected on any of the S. cuboideum plates for the duration of testing. S. ganodermophthorum plates showed only yellow pigment; however, I. hispidus plates showed yellow pigment within the agar, yellow mycelium and dark brown/yellow zone lines, all of which are common pigment components of I. hispidus (Perrin and Towers 1973; Ali et al 1996).…”

Section: Resultsmentioning

confidence: 99%

“…There was no significant amount of internal pigmentation among any of the fungal species at any week. The higher yellow pigment amount produced by I. hispidus early in incubation is most likely due to two factors: the early production of the pigments hispidin and hispolon, are known to decrease markedly after 25 days incubation (Perrin and Towers 1973;Ali et al 1996), and the white rot decay and zone line formation that occurred later in the incubation cycle, as part of the natural decay mechanism of this fungus. The reason for the decrease in the pigments is unknown; however, it may be due to the bleaching effect of the decay mechanism of I. hispidus overlaying the pigments.…”

Section: Wood Blocksmentioning

confidence: 99%

“…The two fungi routinely cited as producing a yellow extracellular pigment within wood are Scytalidium ganodermophthorum Kang, Sigler (Kang et al 2010) and Inonotus hispidus (Bull.) P. Karst (Ali et al 1996; Perrin and Towers 1973). The goal of this research was to determine the potential usage of these two fungi as spalting fungi, based upon their ability to (1) be grown in culture media quickly and reliably produce pigment; (2) to produce yellow pigment internally in standard test blocks of two species of hardwoods within 12 weeks; and (3) to determine if internal pigment production of any of the fungi could occur under non-sterile conditions.…”

Section: Introductionmentioning

confidence: 99%

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Ability of three yellow pigment producing fungi to colour wood under controlled conditions

Robinson

Tudor

Zhang

et al. 2013

International Wood Products Journal

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Inonotus hispidus, Scytalidium ganodermophthorum and two strains of Scytalidium lignicola were tested for their ability to produce yellow extracellular pigment on media plates, sterile wood blocks and non-sterile logs to determine their suitability for use as spalting fungi. All three fungi produced a penetrating yellow pigment in the non-sterile logs after 12 weeks of incubation; however, results from the sterile block tests indicated that the incubation time necessary for I. hispidus to produce sufficient yellow pigment may be as low as 4 weeks of incubation. An incubation period of 4 weeks is the shortest recorded for controlled spalting and will allow for the currently utilised production time for yellow spalted wood of 12 weeks to be substantially decreased using an isolate of I. hispidus as the inoculum.

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Section: Resultsmentioning

confidence: 99%

Section: Wood Blocksmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ability of three yellow pigment producing fungi to colour wood under controlled conditions

Robinson

Tudor

Zhang

et al. 2013

International Wood Products Journal

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“…[14,[17][18][19][20][21] A polyphenol bioactive substance called hispolon (HIS) is found in medicinal mushrooms like Phellinus igniarius, Phellinus linteus and Inonotus hispidus. [22][23][24] HIS has been reported to treat pain and inflammation, [25,26] diabetes, [27] oxidative stress, [28] cancer, [29] viral infections, [30] and also proven to have hepatoprotective, [28] immunomodulatory, [31] and cerebroprotective [32] activities. Several novel compounds were created and tested based on the stated pharmacological properties for diverse activities.…”

Section: Introductionmentioning

confidence: 99%

Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone

Saka

Chitra

Narayanasamy³

2023

J Biochem & Molecular Tox

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Electromagnetic radiation (EMR) from wireless devices, particularly mobile phones, is a potentially growing public health concern. In this study, the neuronal effects of EMR on primary cortical neurons (PCNs) from neonatal rat cerebral cortex and the protective role of hispolon (HIS) and its derivatives were investigated as a measure of cranial exposure during mobile phone use. PCNs were isolated and cultured from day-old neonatal rats, then exposed for 2 h to EMR emitted by a mobile phone operating at a frequency of 2100 MHz with 1.6 W/Kg specific absorption rate (SAR) in call-answered mode treated with HIS and its derivatives. The induction of apoptosis through modulation of pro and anti-apoptotic genes via mitochondrial pathway and the protection by the test compounds was assessed. Pyrazole derivatives decreased apoptosis by modulating the levels of pro and anti-apoptotic genes by reducing the levels of reactive oxygen species (ROS) via mitochondrial damage, which was observed in the EMR exposed PCNs. The pyrazole compounds were found to have antioxidative and anti-apoptotic properties. Thus, the neuroprotective mechanisms of the pyrazole derivatives can be investigated further, which may make them appropriate as lead compounds in developing neuroprotective formulations.

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“…Hispolon, a polyphenolic compound isolated from medicinal mushrooms like Phellinus igniarius, Phellinus linteus, and Inonotus hispidus (21)(22)(23), has been reported to treat pain and inflammation (24,25), diabetes (26), oxidative stress (27), cancer (28), viral infections (29), and also proven to have hepatoprotective (27), immunomodulatory (30), and cerebroprotective (31) activities. Several novel compounds were created and tested based on the stated pharmacological properties for diverse activities.…”

Section: Introductionmentioning

confidence: 99%

Protective role of hispolon pyrazole and hispolon monomethyl ether pyrazole in electromagnetic radiation-induced behavioral, neurochemical, oxidative, and histological changes in rats

Saka

Chitra

Narayanasamy

2023

J Herbmed Pharmacol

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Introduction: Radiofrequency electromagnetic radiation (RF-EMR) from mobile phones was reported to cause neurological damage. Hispolon pyrazole (HP) and hispolon monomethyl ether pyrazole (HMEP) were tested for their RF-EMR protection in rats. Methods: Juvenile Wistar albino rats were exposed to the mobile phone generating 2400 MHz radiation with a maximum power output of 2 W/kg (Specific absorption rate 1.6 W/kg) for 90 days at a rate of 2 hours/day, treated with HP and HMEP at 20 and 40 mg/kg body weight. The elevated plus maze (EMT) test was used for anxiety and exploration evaluation, the forced swim test (FST) for depression, the Morris water maze test and Y-maze test for learning and memory. The oxidative stress markers like glutathione, superoxide dismutase (SOD), catalase (CAT), and malonaldehyde (MDA), and the neurotransmitters such as gamma-aminobutyric acid, glutamate, dopamine, and acetylcholinesterase along with histopathology in the cortex, striatum, and hippocampus were evaluated to establish the mechanism of the neuronal alterations of HP and HMEP against RF-EMR-induced damage. Results: In the current investigation, HP at a higher dose of 40 mg/kg and HMEP at both doses significantly reduced the oxidative stress generated by RF-EMR from mobile phones and altered neurobehavioral, neurotransmitter, and histological alterations. Conclusion: Based on the findings, HP and HMEP at a dose of 40 mg/kg are protective agents against long-term, continuous mobile phone use and can be regarded viable therapeutic agents.

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Hispolon, a yellow pigment from Inonotus hispidus

Cited by 69 publications

References 6 publications

Ability of three yellow pigment producing fungi to colour wood under controlled conditions

Ability of three yellow pigment producing fungi to colour wood under controlled conditions

Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone

Protective role of hispolon pyrazole and hispolon monomethyl ether pyrazole in electromagnetic radiation-induced behavioral, neurochemical, oxidative, and histological changes in rats

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