Hispin, a novel ribosome inactivating protein with antifungal activity from hairy melon seeds

Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation

“…Alpha-momorcharin (a-MMC) is a type I ribosome-inactivating protein which has been shown to exert strong anti-tumour (LeeHuang et al, 1995;Basch et al, 2003), anti-HIV (Puri et al, 2009;Kaur et al, 2011), anti-fungal (Ng et al, 2002) and other pharmacological activities (Ng et al, 2010) and have been long considered as potential therapeutic drugs. However, a-MMC has severe hepatotoxicity when applied in vivo.…”

“…Some RIPs are extremely toxic, such as the ricin and abrin, which belong to type II RIPs; a-MMC and trichosanthin (TCS), which are type I RIPs, are less toxic and have received considerable attention for their medicinal values. Type I RIPs possess anti-tumour (Lee-Huang et al, 1995;Basch et al, 2003), anti-HIV (Puri et al, 2009;Kaur et al, 2011), anti-fungal (Ng and Parkash, 2002) and other pharmacological activities (Ng et al, 2010) and have been considered as potential therapeutic drugs. In fact, as early as 1990, the US Food and Drug Administration has approved TCS for use in Phase I/II clinical trials as an anti-HIV therapeutic (Byers et al, 1990(Byers et al, , 1994.…”

Medical importance of Lactobacillus fermentum lysate as a bioactive agent against some pathogenic Candida and Aspergillus strains

“…In recent years, antibacterial and antifungal peptides have gained a lot of interest, due to their potential use as a new generation of therapeutic agents (Zasloff, 2002). Antifungal proteins such as ribosomeinactivating proteins (Ng and Parkash, 2002) and glucanases (York et al, 2004) have been reported from a variety of sources including bacteria, mammals, insects and plants for treating fungal infections. A novel antifungal pyrrole derivative was recorded from Datura metel leaves (Dabur et al, 2004(Dabur et al, , 2005.…”

A ribosome-inactivating protein (curcin 2) induced from Jatropha curcas can reduce viral and fungal infection in transgenic tobacco

“…Experiments with transgenic plants demonstrated that the type 1 RIPs from Phytolacca americana (Lodge et al 1993;Smirnov et al 1997;Wang et al 1998;Zoubenko et al 2000), Phytolacca insularis (Moon et al 1997), Trichosanthes kirilowii (Lam et al 1996) and Dianthus caryophyllus (Hong et al 1996) act as antiviral proteins in planta. Furthermore, it was demonstrated that some type 1 RIPs have antifungal activity in vitro Ng and Wang 2001;Ng and Parkash 2002;Park and Vivanco 2001;Patrick et al 2003;Wang et al 2001), and in vivo (Corrado et al 2005;Maddaloni et al 1997;Wang et al 1998).…”