2016
DOI: 10.1016/j.tox.2016.05.025
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Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation

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Cited by 20 publications
(20 citation statements)
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“…We detected elevated levels of phosphorylated JNK, but not phosphorylated p38 or ERK, in THP-1 cells incubated with α-MMC ( Figure 4A). This observation matches with previous results that α-MMC was able to activate the JNK pathway in liver cells [31]. To determine whether cytokine expression induced by α-MMC is dependent on the JNK pathway, we pre-treated THP-1 cells with JNK inhibitor SP600125 for 30 min before the addition of α-MMC.…”
Section: α-Mmc-induced Inflammatory Responses Via Jnk Pathwaysupporting
confidence: 89%
“…We detected elevated levels of phosphorylated JNK, but not phosphorylated p38 or ERK, in THP-1 cells incubated with α-MMC ( Figure 4A). This observation matches with previous results that α-MMC was able to activate the JNK pathway in liver cells [31]. To determine whether cytokine expression induced by α-MMC is dependent on the JNK pathway, we pre-treated THP-1 cells with JNK inhibitor SP600125 for 30 min before the addition of α-MMC.…”
Section: α-Mmc-induced Inflammatory Responses Via Jnk Pathwaysupporting
confidence: 89%
“…Against tumor cells, it was demonstrated that both alpha-momorcharin and MAP30-induced apoptosis 35 . Particularly, MAP30 caused little damage to normal cells, 38 whereas cytotoxicity to normal liver cells was observed in alpha-momorcharin 39 . Therefore, the clinical application of MAP30 was expected in cancers or protection for viral infection.…”
Section: Resultsmentioning
confidence: 99%
“…Previous studies have described that α‐MMC shows an inhibitory effect on human breast cancer, MDA‐MB‐231, and MCF‐7 cells, human lung adenocarcinoma epithelial A549 cells, but exhibits only slight cytotoxicity to human breast cancer MDA‐MB‐453 . Currently, a study has shown that the different degrees of cytotoxicity of α‐MMC on normal liver L02 cells, human lung epithelial cell line BEAS‐2B cells, and embryonic kidney cell line AD293 cells are related to their amount of low‐density lipoprotein receptor‐related protein 1 (LRP 1) receptor density on the cell surface , suggesting that the application of α‐MMC is limited by the distribution pattern of the LRP1 on certain cell surface, which is the key factor affecting the amount of the α‐MMC in the cells. CPPs have the potential to overcome this limitation and are a promising tool to transport RIPs into cancer cells .…”
Section: Discussionmentioning
confidence: 99%