Hirsutism secondary to topical testosterone: report of two cases and review of the literature

Abstract

Topical testosterone has been used as a treatment for different vulvar conditions. It is usually well tolerated, although hirsutism and other signs of virilization have been described related to hormonal tests alteration. We report two female patients with vulvar diseases that developed hirsutism after treatment with topical testosterone. Because of its potential virilization, females under this treatment should be closely monitored.

Double-blind, randomized, placebo-controlled trial of a cream containing theStryphnodendron adstringens(Martius) Coville bark extract for suppressing terminal hair growth

“…Eighteen subjects were randomized to placebo and 23 to the active treatment. The median [range] FG score changed from 4 [2-6] to 3 [1][2][3][4][5][6][7][8] in the placebo group compared to 4 [1-5] to 2 [0-6] in the active one. According to the non-parametric Wilcoxon test, there was significant difference between the measurements of FG score performed before and after treatment ( P < 0.001).…”

“…Excess of terminal hair is a frequent complain presented at the clinical practice being import not only for the aesthetic issue, but, mainly, because it may be developed as a part of other pathologies. 8 The excess of terminal hair may be associated to an androgen glandular hyperproduction by ovaries or idiopathic. For the treatment of excess of terminal hair, antiandrogenic drugs may be employed, showing superior efficacy when compared to the use of oral contraceptives.…”