Double-blind, randomized, placebo-controlled trial of a cream containing the<i>Stryphnodendron adstringens</i>(Martius) Coville bark extract for suppressing terminal hair growth

Vicente, R. A.; Silva, V. R. Leite e; Baby, André Rolim; Velasco, Maria Valéria Robles; Bedin, Valcinir

doi:10.1111/j.1468-3083.2009.03088.x

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…Despite, the subfraction (F2.4) of 'barbatimão' extracts showed satisfactory antifungal activity compared to fluconazole and nystatin, suggesting further studies to investigate the mechanisms of action and the possible development of a new antifungal agent (Ishida et al, 2006). In contrast, the paper of Vicente et al (2009), published in the "Journal of The European Academy of Dermatology and Venereology", describes the effectiveness of a cream containing 6.0% extract of the steam bark of barbatimão for dermatological use in the treatment of hirsutism. The most important Brazilian journals were "Memórias do Instituto Oswaldo Cruz," "Brazilian Journal of Pharmacognosy" and "Science and Agrotechnology," with an impact factor of 2,368, 1,754 and 1,098, respectively.…”

Section: Resultsmentioning

confidence: 96%

Trends in the scientific literature on Stryphnodendron adstringens (Leguminosae): an important Brazilian medicinal tree

Souza¹,

Vitorino

Bessa

2020

MSJ

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Stryphnodendron adstringens, commonly known as "barbatimão", is a native Brazilian savannah tree that has been long used in folk medicine due to its phytotherapy properties. The aim of the present study was to perform a scientometric analysis based on articles published in journals indexed in Web of Sci ence database. Seventy publications on barbatimão were found and included in this scientometric research, most of which were published in English. The temporal trend analysis in the number of publications showed that the number of scientific articles about S. adstringens had increased significantly over the years. The papers found were published in 51 scientific journals, most of which are international. The main knowledge gaps relating to S. adstringens were in the fields of environmental sciences, evolutionary biology and genetics. The mains trends in barbatimão studies involves pharmacology pharmacy, forestry and medicinal chemistry. Tannin and medicinal plant were the most frequent keywords, showing its importance as a phytotherapeutic resource. Brazil was responsible for 92.96% of the knowledge about this species, obtained through scientific production. The analysis of the publications found made it possible to understand the current knowledge about the species S. adstringens.

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Section: Resultsmentioning

confidence: 96%

Trends in the scientific literature on Stryphnodendron adstringens (Leguminosae): an important Brazilian medicinal tree

Souza¹,

Vitorino

Bessa

2020

MSJ

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“…Solvent partition [71,87,103] and chromatography [71,109] have been used to partially purify or isolate pure active compounds from a crude plant extract. Plant extracts have been formulated in a solution [45], tonic [121,125], lotion [122], cream [120], shampoo [65,123], or nanoparticles [102,171] for topical application. Tablets and other types of food products have also been manufactured for oral administration [62,126].…”

Section: Discussionmentioning

confidence: 99%

“…Topical application of the products containing Stryphnodendron adstringens bark extract and Curcuma aeruginosa extract reduced the growth of terminal hairs and axillary hairs, respectively, in women [120,122]. In contrast, topical application of the products containing the extract of Thuja occidentalis, Oryza sativa, Curcuma aeruginosa, Centipeda minima, or Silybum marianum increased hair density in all human subjects [65,72,118,121,124,125].…”

Section: You Et Al 2024 [65]mentioning

confidence: 96%

Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets

Choi,

Boo,

Boo

2024

Molecules

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This narrative review aims to examine the therapeutic potential and mechanism of action of plant extracts in preventing and treating alopecia (baldness). We searched and selected research papers on plant extracts related to hair loss, hair growth, or hair regrowth, and comprehensively compared the therapeutic efficacies, phytochemical components, and modulatory targets of plant extracts. These studies showed that various plant extracts increased the survival and proliferation of dermal papilla cells in vitro, enhanced cell proliferation and hair growth in hair follicles ex vivo, and promoted hair growth or regrowth in animal models in vivo. The hair growth-promoting efficacy of several plant extracts was verified in clinical trials. Some phenolic compounds, terpenes and terpenoids, sulfur-containing compounds, and fatty acids were identified as active compounds contained in plant extracts. The pharmacological effects of plant extracts and their active compounds were associated with the promotion of cell survival, cell proliferation, or cell cycle progression, and the upregulation of several growth factors, such as IGF-1, VEGF, HGF, and KGF (FGF-7), leading to the induction and extension of the anagen phase in the hair cycle. Those effects were also associated with the alleviation of oxidative stress, inflammatory response, cellular senescence, or apoptosis, and the downregulation of male hormones and their receptors, preventing the entry into the telogen phase in the hair cycle. Several active plant extracts and phytochemicals stimulated the signaling pathways mediated by protein kinase B (PKB, also called AKT), extracellular signal-regulated kinases (ERK), Wingless and Int-1 (WNT), or sonic hedgehog (SHH), while suppressing other cell signaling pathways mediated by transforming growth factor (TGF)-β or bone morphogenetic protein (BMP). Thus, well-selected plant extracts and their active compounds can have beneficial effects on hair health. It is proposed that the discovery of phytochemicals targeting the aforementioned cellular events and cell signaling pathways will facilitate the development of new targeted therapies for alopecia.

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Interventions for hirsutism (excluding laser and photoepilation therapy alone)

Zuuren

Fedorowicz

Carter

et al. 2015

Cochrane Database of Systematic Reviews

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Double-blind, randomized, placebo-controlled trial of a cream containing theStryphnodendron adstringens(Martius) Coville bark extract for suppressing terminal hair growth

Abstract: The cream with 6.0% of the S. adstringens bark extract was effective on the reduction and on the reversion of the terminal hair excess, being considered a new promissory product for such finality.

Cited by 8 publications

References 10 publications

Trends in the scientific literature on Stryphnodendron adstringens (Leguminosae): an important Brazilian medicinal tree

Trends in the scientific literature on Stryphnodendron adstringens (Leguminosae): an important Brazilian medicinal tree

Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets

Interventions for hirsutism (excluding laser and photoepilation therapy alone)

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