Hippocampal formation and related structures of the limbic lobe: anatomic-MR correlation. Part I. Surface features and coronal sections.

Naidich, Thomas P.; Daniels, David L.; Haughton, V M; Williams, Alicia C.; Pojunas, K W; Palacios, Eva M.

doi:10.1148/radiology.162.3.3809489

Cited by 110 publications

(37 citation statements)

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“…2B-F). In both the human and the macaque brain, the outermost part of the molecular layer of both the retrosplenial cortex and the posterior part of the presubiculum is covered by a richly myelinated fiber bundle (McLardy, 1974;Rosene and Van Hoesen, 1987;Naidich et al, 1987;Benes et al, 1994;Morris et al, 1999a).…”

Section: Human Retrosplenial Cortexmentioning

confidence: 99%

Architectonic analysis of the human retrosplenial cortex

2000

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Section: Human Retrosplenial Cortexmentioning

confidence: 99%

Architectonic analysis of the human retrosplenial cortex

2000

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“…formation, amygdala, and parahippocampal gyrus (PHG) (8)(9)(10)(11)(12). Based on initial studies, MRIbased volume measurements of the MTL have been proposed as a clinically useful test for the diagnosis of AD (13)(14)(15)(16)(17)(18)(19)(20)(21).…”

mentioning

confidence: 99%

Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease

Jack¹,

Petersen²,

et al. 1997

Neurology

974

636

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Magnetic resonance imaging(MRI) based volumetric measurements of medial temporal lobe (MTL) structures can discriminate between normal elderly controls and patients with Alzheimer's disease (AD) of moderate to advanced severity. In terms of clinical utility, however, a more important issue concerns the ability of the technique to differentiate between normal elderly controls and AD patients with the very mildest form of the disease. We performed MRI-based volume measurements of the hippocampus, parahippocampal gyrus, and amygdala in 126 cognitively normal elderly controls and 94 patients with probable AD. The diagnosis of AD was made according to NINDS/ADRDA criteria, and disease severity was categorized by Clinical Dementia Rating (CDR) scores. Patients with CDR = 0.5 were classified as very mild, CDR = 1 as mild, and CDR = 2 moderate disease severity.Volumes of each structure declined with increasing age in control subjects and did so in parallel for men and women. The volume of each measured MTL structure also declined with age in patients with AD. The volume of each MTL structure was significantly smaller in AD patients than control subjects (P<.001). Of the several MTL measures, the total hippocampal volume measurements were best at discriminating controls from AD cases. The mean hippocampal volumes for AD patients relative to controls by severity of disease were as follows: very mild AD (CDR 0.5) -1.75 SD below the control mean, mild AD (CDR 1) -1.99 SD, and moderate AD (CDR 2) -2.22 SD. Age and gender adjusted normalized MRI-based hippocampal volume measurements provide a sensitive marker of the MTL neuroanatomic degeneration in AD early in the disease process. KeywordsAlzheimer's Disease; Dementia; MRI; Quantitative MRI; Hippocampus Alzheimer's disease(AD) is the most common cause of dementia in individuals over 60 years of age(1-3). A well accepted biological concomitant of AD is cerebral atrophy(4). The rationale for quantitative magnetic resonance imaging (MRI) of medial temporal lobe (MTL) atrophy in the diagnosis of AD is: 1) A memory impairment is usually the earliest and most severe clinical manifestation of AD; 2) Medial temporal lobe (MTL) limbic structures are central to the integrity of declarative memory function (5); 3) MTL limbic structures are involved earliest and most extensively in the pathology of AD(6,7); and 4) several principal MTL limbic structures are amenable to accurate volumetric quantitation by MRI-the hippocampal 3) Relatively small numbers of subjects were included in individual studies. 4) Rigorous definitions of the severity of AD often were not employed. Most previous studies have included primarily subjects with AD of moderate severity. Consequently, the differences between the AD patients and control subjects with regard to MTL atrophy have been dramatic. The most important test of the utility of the technique would be in patients with very mild AD in whom the diagnostic decision making process is difficult.We report a large series of carefully evaluated and lon...

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“…L'anatomia macroscopica del complesso sistema limbico e del corpo calloso e ben rappresentata nei tre piani anatomici sia su immagini pesate in Tl che in T2 (figure 5, 6, 7, 8) 6 .7· 8 • 9 • Sulle sezioni sagittali pesate in Tl il corpo calloso, il piu grande sistema di fibre bianche di connessione del cervello umano, si presenta come una semiluna a segnale iperintenso, suddivisa in senso antero-posteriore in rostro, ginocchio, corpo e splenio (figura 5a).…”

Section: Nervi Craniciunclassified

Studio anatomico RM del sistema nervoso centrale

Colombo

Scialfa

1988

Rivista di Neuroradiologia

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Parole chiave: Risonanza Magnetica, anatomia RIASSUNTO-La Risonanza Magnetica (R.M.) e la metodica diagnostica che attualmente fornisce la migliore rappresentazione dell'anatomia morfologica e funzionale del Sistema Nervoso Centrale (SNC). L'alta risoluzione di contrasto e spaziale della metodica, e la possibilita di acquisire immagini dirette nei tre principali piani anatomici (assiale, sagittale e coronale), sono tra i vantaggi che sanciscono la sua superiorita rispetto ad altre modalita di imaging.Le immagini «pesate in Tl» sono le piu idonee per uno studio morfologico-macroscopico delle varie strutture del nevrasse, mentre le immagini «pesate in T2» meglio delineano strutture intrinseche al SNC (fasci di sostanza bianca, nuclei grigi centrali). SUMMARY -Magnetic Resonance Imaging is the most apt diagnostic modality to study macroscopic and June tional anatomy of the Central Nervous System ( CNS).The high contrast and spatial resolution and the possibility to acquire sections in axial, sagittal and coronal planes are some of the major advantages.Tl weighted images provide the best morphologic representation of the anatomic structures of the CNS, while T2 weighted images better visualize intrinsic structure ( i.e. white matter tracts, central grey nuclei) . IntroduzioneIl progresso delle moderne tecniche di imaging ha imposto al neuroradiologo una conoscenza sempre piu minuziosa dell'anatomia del Sistema Nervoso Centrale (SNC).La Risonanza Magnetica (RM) si presenta attualmente come la metodica diagnostica piu idonea a fornire una rappresentazione diretta e incruenta delle piu fini strutture anatomiche del SNC.Questo e vero sia per la possibilita di ottenere sezioni dirette nei tre principali piani anatomici, assiale e, soprattutto, sagittale e coronale, sia per l'alta risoluzione di contrasto e spaziale della metodica che permette l'acquisizione di immagini del tutto paragonabili alle reali sezioni anatomiche.Lo sforzo di definire l'anatomia in modo tanto particolareggiato, non ha ovviamente il valore di un puro esercizio culturale, ma deve rappresentare il tentativo di un sempre migliore inquadramento clinico del paziente.Va oltre lo scopo di questa trattazione una presentazione completa dell'anatomia del SNC, si forniranno pertanto solo brevi cenni anatomici ed esempi di possibilita di studi anatomici con immagini di RM. Meccanismi di contrasto nelle immagini RMIl segnale RM dipende sia da parametri estrinseci, scelti dall'operatore all'atto di impostare le diverse sequenze (tempo di ripetizione = TR, tempo di eco = TE) sia da parametri intrinseci, propri delle diverse strutture in esame, rappresentati da densita protonica e tempi di rilassamento Tl e T2.A livello cerebrale la possibilita di distinguere con l'RM strutture diverse come la sostanza bian-13

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Hippocampal formation and related structures of the limbic lobe: anatomic-MR correlation. Part I. Surface features and coronal sections.

Cited by 110 publications

References 0 publications

Architectonic analysis of the human retrosplenial cortex

Architectonic analysis of the human retrosplenial cortex

Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease

Studio anatomico RM del sistema nervoso centrale

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