Architectonic analysis of the human retrosplenial cortex

Morris, Renée; Paxinos, George; Petrides, Michael

doi:10.1002/(sici)1096-9861(20000522)421:1<14::aid-cne2>3.0.co;2-s

Cited by 41 publications

(47 citation statements)

References 27 publications

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“…The PCC's role in memory is corroborated by a handful of human case reports describing selective PCC lesions and an amnestic syndrome (McDonald, Crosson, Valenstein, & Bowers, 2001;Valenstein et al, 1987;Yasuda, Watanabe, Tanaka, Tadashi, & Akiguchi, 1997). Growing knowledge regarding the PCC's reciprocal anatomical connectivity with mesial temporal, thalamic, and prefrontal regions further supports the PCC's role in mnemonic processing (Kobayashi & Amaral, 2003;Morris, Paxinos, & Petrides, 2000;Morris, Petrides, & Pandya, 1999).…”

Section: Introductionmentioning

confidence: 80%

Task-dependent posterior cingulate activation in mild cognitive impairment

et al. 2006

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Neuroimaging research has demonstrated that the posterior cingulate cortex (PCC) is functionally compromised in individuals diagnosed with amnestic Mild Cognitive Impairment (MCI), a major risk factor for the development of Alzheimer's disease (AD). In functional magnetic resonance imaging (fMRI) studies with healthy participants, this same region is active during self-appraisal (requiring retrieval of semantic knowledge about the self) as well as episodic recognition of recentlylearned information. Administering both types of tasks to people with MCI may reveal important information regarding the role of the PCC in recollection. This study investigated fMRI activation in the PCC in individuals with MCI and age, gender, and education-matched controls across two tasks. The first task was a visual episodic recognition task in which participants indicated whether pictures had or had not been presented during a study session. The second task was an autobiographical self-appraisal task in which subjects rated themselves on a set of trait adjectives. Results of a conjunction analysis revealed the PCC as the sole region commonly active during both tasks in the healthy older adults. Furthermore, additional analysis revealed an interaction in the PCC indicating a task-dependent response in the MCI group. MCI participants showed PCC activation during self-appraisal, but not during episodic retrieval. These results suggest in MCI that the PCC shows functional degradation during episodic retrieval of visual information learned in the laboratory. In contrast, the PCC's role in retrieval and evaluation of highly-elaborated information regarding the self is more well-preserved.

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Section: Introductionmentioning

confidence: 80%

Task-dependent posterior cingulate activation in mild cognitive impairment

et al. 2006

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“…Similarly, fMRI studies show PCC activity correlates positively with anticipatory shifts of spatial attention and that this relationship is strengthened by the presence of monetary incentives (Small et al, 2005) and motivationally relevant targets (Mohanty et al, 2007). Anatomically, the primate cingulate gyrus is interconnected with the amygdala, parahippocampal region, insula, OFC, and inferior parietal lobule (Mesulam et al, 1977; Pandya et al, 1981; Morecraft et al, 1992; Morris et al, 2000) providing additional support for the role of PCC as a potential conduit between the limbic system and the spatial attention network during attentional biasing toward motivationally salient information.…”

Section: Discussionmentioning

confidence: 99%

Search for a Threatening Target Triggers Limbic Guidance of Spatial Attention

Mohanty¹,

Egner²,

Monti³

et al. 2009

J. Neurosci.

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The ability to actively locate potential threats in our environment is highly adaptive. To investigate mediating neural mechanisms, we designed a visual search task in which central cues signaled future location and emotional expression (angry or neutral) of a target face. Cues predicting angry targets accelerated subsequent attention shifts, indicating that endogenous signals predicting threatening events can prime the spatial attention network. Functional imaging showed that spatially informative cues activated the fusiform gyrus (FG) as well as frontoparietal components of the spatial attention network, including intraparietal sulcus (IPS) and frontal eye field (FEF), whereas cues predicting angry faces also activated limbic areas, including the amygdala. Anatomically overlapping, additive effects of spatial and emotional cuing were identified in the IPS, FEFs, and FG, regions that also displayed augmented connectivity with the amygdala after cues predicting angry faces. These data highlight a key role for the frontoparietal spatial attention network in the compilation of a salience map that combines the spatial coordinates of an event with its motivational relevance. Furthermore, they suggest that active search for a threatening stimulus elicits amygdala input to the spatial attention network and inferotemporal visual areas, facilitating the rapid detection of upcoming motivationally significant events.

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“…PCC (Brodmann area 23 and 31) was divided into 3 ROIs 27: a) dorsal PCC (dPCC), which was posterior to the marginal ramus plane and anterior to the ventral branch of the splenial sulci; the latter defined the histological division of areas d23b and v23b, or dorsal and ventral PCC; b) Ventral PCC (vPCC), whose anterior border was dPCC, posterior-inferior border was the common trunk of the calcarine and parieto-occipital sulcus 24;27, and wrapped around the retrosplenial cortex (RSC). c) RSC was bordered by the common truck posteriorly and the callosal sulcus dorso-anteriorly 24. The anterior-lateral segment was buried within the callosal sulcus; while the posterior-ventral end was on the surface of the medial hemisphere of the isthmus of PCC 24.…”

Section: Methodsmentioning

confidence: 99%

“…c) RSC was bordered by the common truck posteriorly and the callosal sulcus dorso-anteriorly 24. The anterior-lateral segment was buried within the callosal sulcus; while the posterior-ventral end was on the surface of the medial hemisphere of the isthmus of PCC 24. To segregate the 3 PCC ROIs, the RSC was drawn first using sagittal slices, which identified the RSC within the callosal sulcus.…”

Section: Methodsmentioning

confidence: 99%

“…The stable spatial organization of resting-state functional connectivity maps suggests that it can be constrained by anatomical connectivity 22;23. Based upon prior knowledge of the functional and histological subdivisions of the cingulate cortex 24-29, we partitioned the entire human cingulate into anatomic subregions. The study is designed to first characterize the resting-state functional connectivity associated with each cingulate subregion, then to identify cingulate circuits that are associated with nicotine addiction and finally to determine how acute nicotine administration affects circuits that are associated with nicotine addiction.…”

Section: Introductionmentioning

confidence: 99%

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Association of Nicotine Addiction and Nicotine's Actions With Separate Cingulate Cortex Functional Circuits

Hong

Yang

et al. 2009

Arch Gen Psychiatry

238

230

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Context Understanding the mechanisms underlying nicotine addiction in order to develop more effective treatment is a public health priority. Research consistently shows that nicotine transiently improves multiple cognitive functions. However, using nicotine replacement to treat nicotine addiction yields generally inconsistent results. While this dichotomy is well known, the reasons are unclear. Imaging studies showed that nicotine challenges almost always involve cingulate cortex, suggesting that this loci may be a key region associated with nicotine addiction and its treatment. Objective To identify cingulate functional circuits that are associated with the severity of nicotine addiction and to study how nicotine affects them. Design Using region-specific resting-state fMRI signals to extract resting-state cingulate functional connectivity, and to study how nicotine addiction and acute nicotine administration modulate these functional pathways, in a double-blind, placebo-controlled design. Setting Outpatient clinics. Participants Nineteen healthy smokers. Intervention(s) Single dose (21/35mg) nicotine patch. Main Outcome Measure(s) Correlation of nicotine addiction severity and cingulate resting state functional connectivity, and effects of acute nicotine on connectivity strength. Results Clearly separated pathways that correlated with nicotine addiction vs. nicotinic action were found. The severity of nicotine addiction was associated with the strength of dorsal anterior cingulate cortex (dACC)-striatal circuits, which were not modified by nicotine patch administration. In contrast, acute nicotine enhanced cingulate-neocortical functional connectivity patterns. Conclusions Nicotine addiction was strongly associated with functional circuits interconnecting dACC and the striatum. Acute nicotine administration had no significant effect on these circuits. Rather, nicotine enhanced several cingulate-neocortical functional connectivity circuits that were not associated with the severity of nicotine addiction, but may play a role in nicotine's cognitive enhancing properties. Resting state dACC-striatum functional connectivity may serve as a circuit-level biomarker for nicotine addiction, and the development of new therapeutics aiming to enhance the dACC-striatum functional pathways may be effective for nicotine addiction treatment.

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Architectonic analysis of the human retrosplenial cortex

Cited by 41 publications

References 27 publications

Task-dependent posterior cingulate activation in mild cognitive impairment

Task-dependent posterior cingulate activation in mild cognitive impairment

Search for a Threatening Target Triggers Limbic Guidance of Spatial Attention

Association of Nicotine Addiction and Nicotine's Actions With Separate Cingulate Cortex Functional Circuits

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