Hipertansif hastalarda plazma aterojenik indeks düzeylerinin incelenmesi

Abstract

Aim: Hypertension is a major risk factor for cardiovascular system. Recent studies showed that atherogenic index of plasma (AIP) has a strong association with cardiovascular morbidity, all-cause mortality, atherosclerosis and severity of coronary artery disease. It also has a relationship with endothelial damage in hypertensive patients. With this study we aim to investigate the association between AIP and hypertension. Methods: A total of 213 patients were enrolled for the study. Patients with previous hypertension, nephrotic syndrome, diabetes mellitus, hypotiroidism diagnosis, patients under statin treatment and patients under 18 years of age were excluded. Diagnosis of hypertension and blood pressure (BP) results were obtained with 24-hour ambulatory blood pressure monitoring (ABPM). AIP was defined as the logarithmic transformation of the triglyceride to high-density lipoprotein-cholesterol ratio. Results: Mean age of the population was 49.2 ± 14.6 years and 41.8% (n=89) was male. According to 24-hour ABPM results, AIP was positively correlated with daytime systolic blood pressure (SBP) (r=0.244, p<0.001), daytime diastolic blood pressure (DBP) (r=0.276, p<0.001), night-time SBP (r=0.259, p<0.001), night-time DBP (r=0.299, p<0.001), average SBP (r=0.213, p=0.002) and average DBP (r=0.296, p<0.001). AIP was also increased in hypertensive patients compared to normotensive subjects (p=0.001). Conclusion: Results of our study showed that AIP was positively correlated with blood pressure and statistically higher in patients with hypertension.

The atherogenic index of plasma as a predictor of mortality in patients with COVID-19

“…High triglyceride and low HDL-C levels are both risk factors for cardiovascular diseases. 35 The AIP combines these two risk factors and several studies performed on this subject and showed that the AIP is associated with atherosclerosis, cardiovascular diseases, diabetes mellitus, hypertension, vascular and endothelial damage 16 , 17 , 18 , 19 , 20 . SARS-CoV-2 affects cardiovascular system on different levels.…”

“… 15 The AIP is associated with chronic diseases such as diabetes, hypertension and cardiovascular disease. 16 , 17 , 18 , 19 , 20 Additionally, the relationship between the severity of viral infections and the AIP has been identified. 21 Moreover, there are studies which discuss the impact of SARS-CoV on the disorders of patients’ lipid profile in long-term, while their short term effects are not clear.…”

Author's response to: Comment on “The atherogenic index of plasma as a predictor of mortality in patients with COVID-19”

“…AIP is already a defined risk factor for cardiovascular system diseases. 3 , 4 , 5 Our aim in this study was to show that AIP is an indicator of COVID-19 mortality independent of cardiovascular diseases. Also as you mentioned ethnicity is important for COVID-19 patients it would be better if we specify the ethnic differences of our patients.…”

Author's response to: “Letter to the Editor: The atherogenic index of plasma as a predictor of mortality in patients with COVID-19”

“…We actually mentioned the relationship between AIP and several illnesses like cardiovascular diseases, atherosclerosis, diabetes mellitus, hypertension. 3 , 4 , 5 , 6 , 7 …”