Highly Stretchable Fiber-Based Potentiometric Ion Sensors for Multichannel Real-Time Analysis of Human Sweat

Xu, Jianan; Zhang, Zhen; Gan, Shiyu; Gao, Han; Kong, Huijun; Song, Zhitang; Ge, Xiaoming; Bao, Yu; Niu, Li

doi:10.1021/acssensors.0c00960

Cited by 63 publications

(60 citation statements)

References 42 publications

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“…In contrast, sweat is easy to access noninvasively through the skin and is rich in important analytes, such as electrolytes (e.g., Na + , Cl − , K + , and pH) and metabolites (e.g., glucose, lactate, and cortisol) [ 21 , 22 ]. Recent studies have shown that potentiometric ion sensors in a wearable format are useful for real-time monitoring of dynamic changes in ion concentrations in sweat during an individual’s activities [ 23 , 24 ]. The on-body monitoring of sodium and chloride ions in sweat can be utilized to indicate dehydration status and to diagnose cystic fibrosis [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

et al. 2021

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Highlights Ultrathin and defect-free graphene ink is prepared through a high-throughput fluid dynamics process, resulting in a high exfoliation yield (53.5%) and a high concentration (47.5 mg mL−1). A screen-printed graphene conductor exhibits a high electrical conductivity of 1.49 × 104 S m−1 and good mechanical flexibility. An electrochemical sodium ion sensor based on graphene ink exhibits an excellent potentiometric sensing performance in a mechanically bent state. Real-time monitoring of sodium ion concentration in sweat is demonstrated. Abstract Conductive inks based on graphene materials have received significant attention for the fabrication of a wide range of printed and flexible devices. However, the application of graphene fillers is limited by their restricted mass production and the low concentration of their suspensions. In this study, a highly concentrated and conductive ink based on defect-free graphene was developed by a scalable fluid dynamics process. A high shear exfoliation and mixing process enabled the production of graphene at a high concentration of 47.5 mg mL−1 for graphene ink. The screen-printed graphene conductor exhibits a high electrical conductivity of 1.49 × 104 S m−1 and maintains high conductivity under mechanical bending, compressing, and fatigue tests. Based on the as-prepared graphene ink, a printed electrochemical sodium ion (Na+) sensor that shows high potentiometric sensing performance was fabricated. Further, by integrating a wireless electronic module, a prototype Na+-sensing watch is demonstrated for the real-time monitoring of the sodium ion concentration in human sweat during the indoor exercise of a volunteer. The scalable and efficient procedure for the preparation of graphene ink presented in this work is very promising for the low-cost, reproducible, and large-scale printing of flexible and wearable electronic devices.

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Section: Introductionmentioning

confidence: 99%

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

et al. 2021

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“…Potentiometric sensors are advantageous because of the simplicity of operation, low power consumption, and their potential for miniaturization [117][118][119]. Recently, wearable-type potentiometric ion sensors (WPISs) integrated with IoT sensing modules have gained significant attention for their applicability toward the real-time monitoring of ion concentration changes in body fluids for healthcare management, sports performance monitoring, and physiological analysis [120,121]. Additionally, they can be employed for the diagnosis of critical nervous disorders and heart failure by monitoring metabolic indicators such as Na + , K + , and pH [122,123].…”

Section: Ion Sensorsmentioning

confidence: 99%

Nanomaterials for IoT Sensing Platforms and Point-of-Care Applications in South Korea

Choi

Lee

Choi

et al. 2022

Sensors

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Herein, state-of-the-art research advances in South Korea regarding the development of chemical sensing materials and fully integrated Internet of Things (IoT) sensing platforms were comprehensively reviewed for verifying the applicability of such sensing systems in point-of-care testing (POCT). Various organic/inorganic nanomaterials were synthesized and characterized to understand their fundamental chemical sensing mechanisms upon exposure to target analytes. Moreover, the applicability of nanomaterials integrated with IoT-based signal transducers for the real-time and on-site analysis of chemical species was verified. In this review, we focused on the development of noble nanostructures and signal transduction techniques for use in IoT sensing platforms, and based on their applications, such systems were classified into gas sensors, ion sensors, and biosensors. A future perspective for the development of chemical sensors was discussed for application to next-generation POCT systems that facilitate rapid and multiplexed screening of various analytes.

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“…Then, 20 µL reference membrane (RM) solution was drop-casted on the Ag/AgCl and dried overnight in ambient conditions. The RM solution was prepared by dissolving 500 mg of the membrane cocktail in 5 mL of THF: 150 mg PVC and 340 mg DOS, 5.5 mg TDMACl, 4.5 mg KTPFB, 808 mg KCl, and 306 mg AgCl powder were mixed and stirred overnight at ambient temperature [50,51]. After the RM dried, a reference protection layer was further covered on the RM.…”

Section: Preparation Of Flexible Electrodesmentioning

confidence: 99%

Solid-Contact Potentiometric Anion Sensing Based on Classic Silver/Silver Insoluble Salts Electrodes without Ion-Selective Membrane

et al. 2021

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Current solid potentiometric ion sensors mostly rely on polymeric-membrane-based, solid-contact, ion-selective electrodes (SC-ISEs). However, anion sensing has been a challenge with respect to cations due to the rareness of anion ionophores. Classic metal/metal insoluble salt electrodes (such as Ag/AgCl) without an ion-selective membrane (ISM) offer an alternative. In this work, we first compared the two types of SC-ISEs of Cl− with/without the ISM. It is found that the ISM-free Ag/AgCl electrode discloses a comparable selectivity regarding organic chloride ionophores. Additionally, the electrode exhibits better comprehensive performances (stability, reproducibility, and anti-interference ability) than the ISM-based SC-ISE. In addition to Cl−, other Ag/AgX electrodes also work toward single and multi-valent anions sensing. Finally, a flexible Cl− sensor was fabricated for on-body monitoring the concentration of sweat Cl− to illustrate a proof-of-concept application in wearable anion sensors. This work re-emphasizes the ISM-free SC-ISEs for solid anion sensing.

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Highly Stretchable Fiber-Based Potentiometric Ion Sensors for Multichannel Real-Time Analysis of Human Sweat

Cited by 63 publications

References 42 publications

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

Nanomaterials for IoT Sensing Platforms and Point-of-Care Applications in South Korea

Solid-Contact Potentiometric Anion Sensing Based on Classic Silver/Silver Insoluble Salts Electrodes without Ion-Selective Membrane

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