Highly singlet oxygen generative water-soluble coumarin substituted zinc(II) phthalocyanine photosensitizers for photodynamic therapy

Electrical and gas sensing properties of novel cobalt(II), copper(II), manganese(III) phthalocyanines carrying ethyl 7-oxy-4,8-dimethylcoumarin-3-propanoate moieties

“…The type of substituents, such as long ester chains, influence the photophysical parameters of coumarin. The introduction of monohydroxycoumarin derivatives into the peripheral/nonperipheral ring of phthalocyanines increases the photophysicochemical properties of phthalocyanines [8][9][10]. Therefore, the combination of coumarin and Pc functional groups into a single hybrid compound via a suitable synthetic methodology is expected to produce highly functional compounds with intriguing physicochemical properties.…”

Synthesis, characterization and electrochemical properties of tetra 7-oxy-3-biphenylcoumarin substituted metal-free, zinc(II), cobalt(II) and indium(III) phthalocyanines

“…Our previous research on the Pc compounds involving 2H-1-benzopyran-2-one unit at the non-periphery/periphery of the Pc core showed that the introduction of coumarin derivatives into the nonperipheral/peripheral ring of Pcs remarkably affects photochemical, photophysical, spectral and electrochemical properties of Pcs [22][23][24]. Recently, coumarinoPcs prepared by our group exhibited excellent fluorescence properties with singlet oxygen quantum yield of almost unity which reflects the usability of a compound as a photosensitizer in photocatalytic applications for instance in photodynamic thearaphy (PDT) [5,[24][25][26].…”

Synthesis and in vitro Anticancer Activity of Zinc(II) Phthalocyanines Conjugated with Coumarin Derivatives for Dual Photodynamic and Chemotherapy

“…[32][33][34][35][36] 7-Hydroxycoumarin is a highly effective anticancer agent against malignant melanoma, leukemia, renal cell carcinoma, and prostate and breast cancers; it works through inhibition of cell proliferation by decreasing the release of cyclin D1, which is overexpressed in many types of cancer. [38][39][40][41][42][43][44] A recent study indicated that butanoic acid bearing coumarin-substituted zinc(II) phthalocyanine (ZnPc) complexes and their sodium salts show excellent solubility in aqueous solution and are highly efficient singlet oxygen generators, but these coumarinsubstituted ZnPc complexes cannot exhibit cooperative anti-The combination of photodynamic therapy and chemotherapy is a promising strategy to overcome growing problems in contemporary medicine, such as low therapeutic efficacy and drug resistance. [38][39][40][41][42][43][44] A recent study indicated that butanoic acid bearing coumarin-substituted zinc(II) phthalocyanine (ZnPc) complexes and their sodium salts show excellent solubility in aqueous solution and are highly efficient singlet oxygen generators, but these coumarinsubstituted ZnPc complexes cannot exhibit cooperative anti-The combination of photodynamic therapy and chemotherapy is a promising strategy to overcome growing problems in contemporary medicine, such as low therapeutic efficacy and drug resistance.…”