Highly Sensitive Spectrophotometric Methods for the Determination, Validation and Thermogravimetric Analysis of Antiulcer Drugs, Nizatidine and Ranitidine in Pure and Pharmaceutical Preparations

Nizatidine is a histamine H2 receptor antagonist. This compound belongs to the class of organic compounds known as 2,4‐di‐substituted thiazoles. These are the compounds containing a thiazole ring. It inhibits the action of histamine mediated by H2 receptors such as gastric acid and pepsin output and the drug is used for the treatment of duodenal ulcers. This review presents an overview about the different analytical methods for the analysis of Nizatidine and its metabolite in biological fluids, commercial products, and simultaneous estimation of other H2 receptor antagonist in commercial products. The most commonly used analytical method for Nizatidine is high‐performance liquid chromatography. This review also gives information about pharmacokinetics, its application and susceptibility of H2 receptor antagonist to metabolism by gastrointestinal flora.

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“…By using statistical methods like t-test and Ftest. No significant changes were observed in accuracy and precision [31].…”

Section: Tga-differential Scanning Calorimetry (Dsc)-uv Spectroscopymentioning

confidence: 76%

Analytical techniques for Nizatidine: A review

Rathore

Doijode

et al. 2019

Separation Science Plus

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“…A number of techniques have been used to test the crystal forms of medicines, such as X-ray diffraction (XRD), 7,8 Infrared (IR), 9,10 Raman, 10,11 circular dichroism 12 spectra, differential scanning calorimetry (DSC), 13 thermogravimetric analysis (TGA), 14 differential thermal analysis (DTA), 15 solid-state nuclear magnetic resonance, 16 magnetic anisotropy, 17 dilatometer and polarizing microscope. 18 However, each individual technique has its own limitation 19 and usually need two or more techniques combined to study the crystalline states of hydrates.…”

Section: Introductionmentioning

confidence: 99%