Highly sensitive and robust peroxidase-like activity of porous nanorods of ceria and their application for breast cancer detection

Tian, Zhimin; Li, Jing; Zhang, Zhiyun; Gao, Wei; Zhou, Xuemei; Qu, Yongquan

doi:10.1016/j.biomaterials.2015.04.039

Cited by 227 publications

(143 citation statements)

References 52 publications

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“…As the newest research in this field, Tian et al exploited the peroxidase-like activity of CeO 2 -NPs for breast cancer cell detection using nanostructure-based enzyme-linked immunosorbent assay (ELISA). 2 In the designed system, the primary antibody against a biomarker of breast cancer (CA15-3) was coated on the ELISA plate and the second antibody was directly conjugated on the surface of CeO 2 -NPs through electrostatic forces. In the presence of cancer cells, the primary antibody could capture the cells and the secondary antibody-conjugated CeO 2 -NPs would attach to them, causing oxidation of H 2 O 2 and color change.…”

Section: Angiogenesis Inductionmentioning

confidence: 99%

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Cerium oxide nanoparticles: green synthesis and biological applications

Charbgoo

Ahmad

Darroudi

2017

IJN

256

125

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CeO 2 nanoparticles (NPs) have shown promising approaches as therapeutic agents in biology and medical sciences. The physicochemical properties of CeO 2 -NPs, such as size, agglomeration status in liquid, and surface charge, play important roles in the ultimate interactions of the NP with target cells. Recently, CeO 2 -NPs have been synthesized through several bio-directed methods applying natural and organic matrices as stabilizing agents in order to prepare biocompatible CeO 2 -NPs, thereby solving the challenges regarding safety, and providing the appropriate situation for their effective use in biomedicine. This review discusses the different green strategies for CeO 2 -NPs synthesis, their advantages and challenges that are to be overcome. In addition, this review focuses on recent progress in the potential application of CeO 2 -NPs in biological and medical fields. Exploiting biocompatible CeO 2 -NPs may improve outcomes profoundly with the promise of effective neurodegenerative therapy and multiple applications in nanobiotechnology.

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Section: Angiogenesis Inductionmentioning

confidence: 99%

“…[1][2][3][4][5] In general, cerium can exist in two oxidation states: Ce 3+ and Ce 4+ . Therefore, cerium dioxide can have two different oxide forms, CeO 2 (Ce 4+ ) or Ce 2 O 3 (Ce 3+ ), in bulk material.…”

Section: Introductionmentioning

confidence: 99%

Cerium oxide nanoparticles: green synthesis and biological applications

Charbgoo

Ahmad

Darroudi

2017

IJN

256

125

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“…The utilization of nanoceria as oxidase under some special circumstances was also reported. Recently, nanoceria have been used for several applications either in biotic conditions or abiotic conditions, such as antioxidants, [63][64][65] capping [36] and neuroprotection agents, [66][67][68][69][70][71][72] biosensors, [23,28,73] immunoassays, [31,32,74] color indicator [27,[75][76][77][78][79] and so on.…”

Section: Bio-application Prospects Of Nanoceria As Enzyme Mimeticsmentioning

confidence: 99%

“…Previous studies demonstrated that nanoceria possessed enzyme-like catalytic activity and were stable over a wide range of pH values and temperatures compared with natural enzyme horseradish peroxidase. [27,28] One of our ongoing works implies that activated nanoceria could maintain their catalytic activity at a higher level than native SOD at harsh pH and temperature conditions. Therefore, nanoceria present a promising enzyme mimetics for future applications.…”

Section: Parameters Influencing the Enzyme Mimetic Activities Of Nanomentioning

confidence: 99%

“…[26] Compared with natural enzymes, nanoceria are generally considered to have better heat and pH stability. Studies conducted by Jiao et al [27] and Tian et al [28] demonstrated that nanoceria possessed enzyme-like catalytic activity and chemical stability over a wide range of pH values and temperatures compared with natural enzyme horseradish peroxidase. However, several reports showed that nanoceria would gradually lose their activity due to the changed surface chemistry during the catalysis, [29,30] and the regeneration of catalytic activity may take several days or even weeks.…”

Section: Introductionmentioning

confidence: 99%

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Ceria Nanoparticles as Enzyme Mimetics

Wang

Zhang

et al. 2017

Chin. J. Chem.

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In the past decades, enzyme mimetics based on ceria nanoparticles (nanoceria) have been developed as potential substitutes for nature enzymes. The mixed valence states of cerium and the patterns of oxygen vacancies on crystal planes result in different enzyme mimetic activities. In this review we survey the bio-applications of nanoceria-based enzyme mimetics as well as the underlying mechanisms. Factors influencing the enzyme mimetic activities and future perspective of nanoceria-based enzyme mimetics are also addressed.

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Self‐Amplified Competitive Coordination of MnO₂‐Doped CeO₂ Nanozyme for Synchronously Activated Combination Therapy

Chen

Liu

Guo

et al. 2022

Adv Funct Materials

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Tumor-specific combination therapy has shown great promise in cancer theranostics. However, the therapeutic efficacy is usually suppressed because most of the therapeutic systems are not able to synchronously activate their different therapeutic approaches and the local concentration of tumorassociated stimulus is generally insufficient to fully activate the combination therapy process. Herein, a MnO 2 -doped CeO 2 nanozyme-based nanomedicine (Ce6@CMNRs) is reported for tumor-specific synchronously activated chemodynamic/photodynamic combination therapy. The tumor-overexpressed H 2 O 2 substitutes the Ce6 on Ce6@CMNRs surfaces via competitive coordination and then decomposes into •OH under acidic condition, achieving the chemodynamic therapy (CDT). Meanwhile, the substituted Ce6 triggers photodynamic therapy (PDT) under laser irradiation that is suppressed before the substitution occurs. Thus, H 2 O 2 can synchronously activate both CDT and PDT of Ce6@CMNRs with a similar level in tumor sites. Moreover, the activated PDT-induced oxygen starvation further triggers the generation of H 2 O 2 to continuously replace the residual Ce6 coordinated on the nanorod surface, thereby leading to the full activation of PDT and CDT. Also, the doped MnO 2 enhances the generation of •OH and provides high contrast for magnetic resonance imaging (MRI) with the help of glutathione. Therefore, Ce6@CMNRs are promising candidates for MRI-guided CDT/PDT combination therapy with minimized side effects and high efficiency.

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Highly sensitive and robust peroxidase-like activity of porous nanorods of ceria and their application for breast cancer detection

Cited by 227 publications

References 52 publications

Cerium oxide nanoparticles: green synthesis and biological applications

Cerium oxide nanoparticles: green synthesis and biological applications

Ceria Nanoparticles as Enzyme Mimetics

Self‐Amplified Competitive Coordination of MnO₂‐Doped CeO₂ Nanozyme for Synchronously Activated Combination Therapy

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Highly sensitive and robust peroxidase-like activity of porous nanorods of ceria and their application for breast cancer detection

Cited by 227 publications

References 52 publications

Cerium oxide nanoparticles: green synthesis and biological applications

Cerium oxide nanoparticles: green synthesis and biological applications

Ceria Nanoparticles as Enzyme Mimetics

Self‐Amplified Competitive Coordination of MnO2‐Doped CeO2 Nanozyme for Synchronously Activated Combination Therapy

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Product

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Self‐Amplified Competitive Coordination of MnO₂‐Doped CeO₂ Nanozyme for Synchronously Activated Combination Therapy