Highly selective electrochemical detection of serotonin on polypyrrole and gold nanoparticles-based 3D architecture

Tertiş, Mihaela; Cernat, Andreea; Lacatiș, Daniela; Florea, Anca; Bogdan, Diana; Suciu, Maria; Săndulescu, Robert; Cristea, Cécilia

doi:10.1016/j.elecom.2016.12.015

Cited by 96 publications

(34 citation statements)

References 36 publications

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“…Therefore, it plays a pivotal role in biological and physical processes by regulation mood, sleep, emesis, cardiovascular function and appetite [1][2][3][4]. Therefore, it plays a pivotal role in biological and physical processes by regulation mood, sleep, emesis, cardiovascular function and appetite [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…fluorimetry [8], chemiluminescence [9], HPLC-ECD [10,11], LC-MS [12,13], coulometry [14], capillary electrophoresis [15]. For this purpose, various materials including multiwalled carbon nanotubes [6,7,16,17], graphene based structure [5,3,18], conductive polymers [19][20][21], metal nanoparticles [1,3], metal oxides [2,5], and molecular imprinted polymers [22] have been used as modifiers for the serotonin determination in the literature. In this regard, electrochemical techniques are considered as the alternative tool for clinical diagnostic of 5-HT due to simplicity, fast response, high sensitivity and selectivity, ability to sense in living organism and in-vivo real time detection [3].…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Determination of Serotonin Using Pre‐treated Multi‐walled Carbon Nanotube‐polyaniline Composite Electrode

2018

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In this study, the multiwalled carbon nanotube‐poly (aniline) (MWCNT‐PANI) composite is successfully deposited on the glassy carbon electrode (GCE) by electropolymerization as an efficient and conventional route. The structural and chemical properties of the MWCNT‐PANI was investigated by various spectroscopic and analytical techniques, scanning electron microscopy (SEM), X‐Ray photoelectron spectroscopy (XPS) and electrochemical impedance spectroscopy (EIS). After that, the electrochemical oxidation behavior of serotonin (5‐HT) in phosphate buffer solution (pH 7.4) was examined using cyclic voltammetry (CV). Besides, the MWCNT‐PANI/GCE used for the detection of 5‐HT with linear concentration range (1.0×10−7–1.2×10−5 mol L−1), low limit of detection (3.3×10−8 mol L−1) under differential pulse voltammetric (DPV) conditions. The proposed electrochemical sensor based on MWCNT‐PANI is both time and cost effective, has good reproducibility, high selectivity as well as stability for 5‐HT determination. The developed composite electrode was used to detect 5‐HT in synthetic urine sample and satisfactory results were obtained with high recoveries.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical Determination of Serotonin Using Pre‐treated Multi‐walled Carbon Nanotube‐polyaniline Composite Electrode

2018

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“…Polypyrrole (PPy) is especially promising conducting polymers in the field of electrochemical sensors fabrication. In comparison with several conducting polymers, PPy possesses a high environmental stability, an easy synthesis and a higher electrical conductivity .…”

Section: Introductionmentioning

confidence: 99%

A Facile Strategy for Construction of Sensor for Detection of Ondansetron and Investigation of its Redox Behavior and Thermodynamic Parameters

et al. 2018

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A sodium dodecylsulfate‐doped polypyrrole (SDS‐PPy) film was elaborated on glassy carbon electrode (GCE) by an electrodeposition method in phosphate buffer solution (pH 2.0) containing pyrrole (Py) and sodium dodecyl sulfate (SDS). SDS‐PPy/GCE was used for the construction of sensor, which showed excellent electrochemical response for the detection of ondansetron (OND) compared to conventional PPy. The application of the square wave (SW), with the adsorptive accumulation, indicates a maximum response at 1.33 V in H2SO4 (0.5 M). The influence of experimental parameters on determination of OND is discussed. The adsorptive stripping technique showed to be more sensitive, giving responses twice as big as those of non‐accumulated OND. The substantial improvement of response permits the development of an electroanalytical technique with a linear concentration in the range (1.0–80 μM), low detection (0.09 μM), and quantification limits (0.3 μM), and acceptable relative standard deviations of repeatability (0.59 %), and reproducibility (1.51 %). Consequently, this electrode is promising candidate for an accurate electroanalytical determination of OND in pharmaceutical samples with high sensitivity and selectivity, good accuracy and precision. The electrooxidation of OND at SDS‐PPy/GCE at various temperatures were studied by cyclic voltammetry to evaluate both the kinetic (ks and Ea) and thermodynamic (ΔG*, ΔH* and ΔS*) parameters.

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“…Among conductive polymers, polypyrrole and its derivatives have been studied intensely in recent years and have gained astounding significance due to a series of advantages they bring: facile and efficient electrosynthesis, high environmental stability, biocompatibility and reproducibility . The literature recently describes polypyrrole nanoparticles based platforms for the detection of a wide range of molecules such as: inosine monophosphate , glucose , heavy metals and neurotransmitters . However, the main disadvantage of pyrrole is the lack of functional groups.…”

Section: Introductionmentioning

confidence: 99%

Poly‐(pyrrole‐3‐carboxylic acid) Based Nanostructured Platform for the Detection of Carcinoembryonic Antigen

et al. 2018

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A nanostructured platform based on pyrrole 3‐carboxylic acid was developed and it was used for the detection of carcinoembryonic antigen, a biomarker for gastro‐intestinal tract cancers. The conductive polymer offers possibilities for functionalization due to the presence of the carboxylic group. The platform was tailored by polymerizing pyrrole 3‐carboxylic acid at the surface of a graphite‐based screen‐printed electrode by using multiple pulse amperometry and cyclic voltammetry. The carboxylic groups were activated, facilitating the formation of amide covalent bonds with the terminal amine groups from the antibody. Each step's optimization was tracked by performing electrochemical impedance spectroscopy. The immunosensor was successfully applied for the detection of carcinoembryonic antigen in synthetic samples. By comparing pyrrole 3‐carboxylic acid with pyrrole, significantly greater increases of the charge transfer resistance were achieved by using the functionalized monomer for the immobilization step. The binding of the anti‐CEA was reproducible and directly proportional with its concentration. The increase of the charge transfer resistance after the incubation with carcinoembryonic antigen was linearly correlated with the concentration of the sample and the LOD was 33.33 pg mL−1. A simple nanostructured platform for the label‐free detection of a carcinogenic biomarker molecule was developed, thus holding great opportunities for clinical diagnostics and other biosensor applications.

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Highly selective electrochemical detection of serotonin on polypyrrole and gold nanoparticles-based 3D architecture

Cited by 96 publications

References 36 publications

Electrochemical Determination of Serotonin Using Pre‐treated Multi‐walled Carbon Nanotube‐polyaniline Composite Electrode

Electrochemical Determination of Serotonin Using Pre‐treated Multi‐walled Carbon Nanotube‐polyaniline Composite Electrode

A Facile Strategy for Construction of Sensor for Detection of Ondansetron and Investigation of its Redox Behavior and Thermodynamic Parameters

Poly‐(pyrrole‐3‐carboxylic acid) Based Nanostructured Platform for the Detection of Carcinoembryonic Antigen

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