A Facile Strategy for Construction of Sensor for Detection of Ondansetron and Investigation of its Redox Behavior and Thermodynamic Parameters

Abstract

A sodium dodecylsulfate‐doped polypyrrole (SDS‐PPy) film was elaborated on glassy carbon electrode (GCE) by an electrodeposition method in phosphate buffer solution (pH 2.0) containing pyrrole (Py) and sodium dodecyl sulfate (SDS). SDS‐PPy/GCE was used for the construction of sensor, which showed excellent electrochemical response for the detection of ondansetron (OND) compared to conventional PPy. The application of the square wave (SW), with the adsorptive accumulation, indicates a maximum response at 1.33 V in H2SO4 (0.5 M). The influence of experimental parameters on determination of OND is discussed. The adsorptive stripping technique showed to be more sensitive, giving responses twice as big as those of non‐accumulated OND. The substantial improvement of response permits the development of an electroanalytical technique with a linear concentration in the range (1.0–80 μM), low detection (0.09 μM), and quantification limits (0.3 μM), and acceptable relative standard deviations of repeatability (0.59 %), and reproducibility (1.51 %). Consequently, this electrode is promising candidate for an accurate electroanalytical determination of OND in pharmaceutical samples with high sensitivity and selectivity, good accuracy and precision. The electrooxidation of OND at SDS‐PPy/GCE at various temperatures were studied by cyclic voltammetry to evaluate both the kinetic (ks and Ea) and thermodynamic (ΔG*, ΔH* and ΔS*) parameters.

A Review on Impedimetric and Voltammetric Analysis Based on Polypyrrole Conducting Polymers for Electrochemical Sensing Applications

“…Electrically conductive polymers are a class of materials that can be fabricated to generate either transient or static electrical charges because of their physico-chemical properties [ 4 ]. Among those polymers, PPy is the most extensively used as a conducting polymer in electrochemical sensing applications because it is a heterocyclic conducting polymer, with good environmental stability, high electronic conductivity, and biocompatibility compared to other CPs [ 5 , 6 , 7 , 8 ].…”

Selective Ion‐pair Potentiometric Sensor for the Determination of Ondansetron Hydrochloride in Different Matrixes

“…reported a glass carbon electrode modified by sodium dodecyl sulfate‐polypyrrole. The electrode showed an excellent electrochemical response to ondansetron [8] . Finally, Abbas et al .…”

“…The result can be justified by the removal of drug positive charge and transition into the molecular state where the solubility in the aqueous solution drastically diminished. [17] Thus, a pH value 4.5 [17] (OND + molybdophosphoric acid) + DBPh 59.610 7.30 × 10 À 5 -1.00 × 10 À 2 -3 - [9] (tetrakis as an ion exchanger, and calix-[4]-arene as an ionophore) + Te recipe included NPOE as a plasticizer, 59.700 2.68 × 10 À 5 -4.07 × 10 À 4 5.32 -100.01-98.26 [6a] Voltammetric Sensor carbon paste electrode modified electrode with Polyvinyl Pyrrolidone and multi-walled carbon nanotube -2.00 × 10 À 9 -2.00 × 10 À 7 430 × 10 À 6 -- [7] A sodium dodecylsulfate-doped polypyrrole film elaborated on a glassy carbon electrode -1.00 × 10 À 6 -8.00 × 10 À 5 0.30 0.09 - [8] Figure 5. Effect of pH on the potential response of (OND-RA).PVC.SE.…”

“…The electrode showed an excellent electrochemical response to ondansetron. [8] Finally, Abbas et al synthesized a membrane electrode from ion-pair (ondansetron-phospho-molybdenum acid) modified PVC in the presence of four plasticizers: dibutyl phthalate (DBPh), dioctyl phthalate (DOPh), orto-nitrophenyl octyl ether (O-NPOE), or dibutyl phosphate (DBP) separately. DBPh has proven best plasticizer with an electrode lifetime of 30 days.…”

Novel potentiometric sensors for determination of ondansetron hydrochloride in pure and dosage form

“…2,3 For anti-anxiety, the normal dosage is 8-32 mg per day, and for anxiety disorder, the initial results from clinical recommendations suggested lower levels of 2-4 mg per day. 3 Over time, methods have been developed for the determination of ondansetron by liquid chromatography (LC), 4,5 highperformance liquid chromatography (HPLC), 6,7 ion-pair chromatography, 8 liquid chromatography mass spectrometry (LC-MS), 9,10 capillary zone electrophoresis, 11,12 ow injection atomic absorption spectroscopy, and ultraviolet (UV) spectrophotometry. [13][14][15] Ninama et al improved and validated a mass spectrometry method for concentrations of 1.00-100.00 ng mL À1 with a lower limit of quantitation (LLOQ) at approximately 1.00 ng mL À1 , and shorter stability time for analysis of ondansetron solutions at approximately 7 h 10 min.…”