Highly polarized enamines. 2. Synthesis and investigation of the further amination of derivatives of ?,?-DIAMINO-?-cyano-?-nitroethylene

Transformations of 5‐nitropyrimidines

“…The authors showed that this transformation is also valid for a considerable variety of 6-amino derivatives. On the other hand, attempts to prepare enediamines containing arylamino group in α-position of the enamine encountered considerable difficulties [65]. Deactivating influence of 6-arylamino group upon 4-chlorine atom is less pronounced than in the case of amino or alkylamino substituent and, hence, interaction between 4,6-dichloro-5-nitropyrimidine 96 and aromatic amines proceeds ambiguously, giving rise not only to the target chloropyrimidines, but also to 4,6-bisarylamino-5-nitropyrimidines 98, which cannot undergo transformation into enamines.…”

Synthesis and properties of β,β-bisfunctionalised keteneN,N-acetals

“…It has been found recently 119 that the `push-pull' enamines 129 with at least one nonsubstituted amino group readily react with amidoacetals to give the corresponding amidines 130 and 131 and the reaction rate depends on the extent of of the other amino group (NH 2 > NHMe > NMe 2 ).…”

An Efficient Synthesis and Antibacterial Activity of Pyrido[2,3‐d]Pyrimidine, Chromeno[3,4‐c]Pyridine, Pyridine, Pyrimido[2,3‐c]Pyridazine, Enediamines, and Pyridazine Derivatives

“…Pyrido [2,3‐d]pyrimidines present particularly valuable biological activities such as antitumor , antimicrobial , diuretic , inhibiting dihydrofolate reductases, and tyrosine kinases . Enamines have been successfully utilized as building blocks for the synthesis of polyfunctionalized heterocycles and other related condensed system . In this repot a rapid one‐pot synthesis of enediamines with high yield and pure crystals by using arylazomalononitriles, whereas enediamines reported earlier after six separated successful steps .…”