An Efficient Synthesis and Antibacterial Activity of Pyrido[2,3‐d]Pyrimidine, Chromeno[3,4‐c]Pyridine, Pyridine, Pyrimido[2,3‐c]Pyridazine, Enediamines, and Pyridazine Derivatives

Abstract

A series of Pyrido[2,3‐d]pyrimidine have been synthesized through a reaction of cyanoacetylurea derivatives with aromatic aldehydes or Arylidines. Reaction of compound 1 with aromatic arylidine derivatives or arylhydrazones gave Chromeno[3,4‐c]pyridine, Pyridine, Pyrimido[2,3‐c]pyridazine, Enediamines, and Pyridazine derivatives. All the synthesized compounds were confirmed by spectral studies and screened for their in antibacterial activity against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative) bacterial strains. All the compounds were weak to good active against the tested bacterial strains on comparing with the standard drug gentamicin.

Potential Nitrogen-Based Heterocyclic Compounds for Treating Infectious Diseases: A Literature Review

“…Antibacterial activity was performed for all the targeted compounds against E. coli and S. aureus strains using gentamicin as a standard drug. From the data of the antibacterial activity, it was observed that the compounds 316 , 320 , 319 , 322 and 321 had displayed tremendous activity across all the strains with a 16.5 to 24mm zone of inhibition (ZOI) value compared to the reference drug (ZOI 15 mm) [ 39 ]. Pyrimidine ( 326 – 332 ) and pyridine ( 333 – 341 ) were synthesized according to Scheme 26 and screened against different bacteria [ 40 ].…”

Synthesis and evaluation of antioxidant and antimicrobial activity of new spiropyridine derivatives using Ag/TiO2/Fe3O4@MWCNTs MNCs as efficient organometallic nanocatalyst

“…Among the heterocyclic compounds, pyridine and their analogues are the most interesting structural units due to their broad spectrum of applications [ 1 ] in natural products, [ 2 ] pharmaceutical, [ 3 ] agrochemical, [ 4 ] and material science. [ 5,6 ] Many of the fused pyridine compounds have been confirmed as valuable candidates possessing anti‐bacterial, [ 7 ] anti‐fungal, [ 8 ] anti‐microbial, [ 9 ] anti‐oxidant, [ 10,11 ] anti‐cancer, [ 12,13 ] anti‐psychotic, [ 14 ] anti‐inflammatory, [ 15,16 ] anti‐leishmanial, [ 17 ] anti‐viral, [ 18 ] antihypersensitive, [ 19 ] anti‐convulsants, [ 20 ] anti‐malarial, [ 21 ] potassium channel openers, [ 22 ] anti‐diabetic, [ 23 ] and anti‐tumor activities. [ 24 ] Spiro compounds having cyclic structures fused at a central carbon are of interest due to their interesting conformational features and their structural implications on biological systems.…”

Synthesis of Some Novel Furan‐tagged Thienopyrimidine Derivatives as Antibacterial Agents

“…Thienopyrimidines, including the three fundamental systems (thieno[2,3‐ d ]pyrimidine, thieno[3,2‐ d ]pyrimidine, and thieno[3,4‐ d ]pyrimidine), are among those fused pyrimidines that are found to have a wide variety of pharmacological activities. Many thienopyrimidines have been found to exhibit a variety of pronounced activities as antimicrobial , anticancer , and antiviral agents. Moreover, the literatures advertised that thienopyrimidines bearing furan moiety (Fig.…”

“…Fused pyrimidines have attracted considerable interest in the medicinal chemistry research because of their versatility and wide bioactive potential . Thienopyrimidines, including the three fundamental systems (thieno[2,3‐ d ]pyrimidine, thieno[3,2‐ d ]pyrimidine, and thieno[3,4‐ d ]pyrimidine), are among those fused pyrimidines that are found to have a wide variety of pharmacological activities.…”