Highly Efficient Binding of DNA on the Sidewalls and Tips of Carbon Nanotubes Using Photochemistry

Abstract

The sidewalls of vertically aligned, multiwalled carbon nanotubes were functionalized using azide photochemistry, and DNA oligonucleotides were synthesized in situ from the reactive group on each photoadduct to produce water-soluble DNA-coated nanotubes. The functional DNA sites on the nanotubes were visualized from gold nanoparticles modified with complementary DNA and using TEM. The sidewall functionalization enabled further DNA-directed modification of the nanotubes' surfaces with nanoparticles. The DNA-coated vertically aligned nanotubes offer the architecture for a highly loaded three-dimensional DNA chip.

Carbon Nanotube and Gold‐Based Materials: A Symbiosis

“…The same properties of the SDS-functionalized MWNTs were also demonstrated to be useful for mediating the attachment of AuNPs onto the surface of the tubes. This strategy [66][67][68] through a noncovalent approach may be superior to those of using covalent approaches due to the ability to maintain the electrical and structural properties of the CNTs. Further applications of the LBL-assembled CNT multi-layer films and the AuNPs/ MWNT nanohybrids are in the development of bio-electronic nanodevices such as biosensors and biofuel cells.…”

Carbon Nanotubes Supported Metal Nanoparticles for the Applications in Proton Exchange Membrane Fuel Cells (PEMFCs)

“…Surface modification of CNTs by non-covalent functionalization is particularly attractive due to its possibility to preserve the electronic network of CNTs (Dyke & Tour, 2004;Moghaddam et al, 2004). The non-covalent functionalization of CNTs is mainly through adsorption of functional molecules via their interactions with CNTs by van der Waals forces, electrostatic forces, hydrogen bonding, and other attractive forces (Y.…”

Carbon Nanotubes - A Potential Material for Affinity Biosensors

“…Cai et al,2003 reported the application of CNTs to the fabrication of an electrochemical DNA biosensor for the specific DNA sequence detection. Moghaddam et al, 2004 firstly reported the azide photolysis for the functionalization of CNTs. They used the azide-photochemistry to functionalize the sidewalls and tips of CNTs in a solid-state reaction and the subsequent synthesis of a DNA oligonucleotide from the reactive group on each photo-adduct.…”