High Serum Thyrotropin Levels Are Associated with Retinal Arteriolar Narrowing in the General Population

Ittermann, Till; Dörr, Marcus; Völzke, Henry; Tost, Frank; Lehmphul, Ina; Köhrle, Josef; Jürgens, Clemens

doi:10.1089/thy.2014.0190

Cited by 24 publications

(19 citation statements)

References 39 publications

(54 reference statements)

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“…However, so far no studies investigated whether and to which extent measurements of aortic and carotid wall thickness are correlated. Furthermore, the results of our study are in agreement with several other population-based studies which reported associations between high TSH and markers closely related to atherosclerosis such as endothelial dysfunction [32], heart valve sclerosis [33], retinal arteriolar narrowing [34] and oxidized low-density lipoprotein [35]. Hence, there is some evidence that serum TSH levels are positively associated with atherosclerosis, which is further supported by the results of our study.…”

Section: Discussionsupporting

confidence: 93%

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High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

Ittermann

Lorbeer²,

Dörr

et al. 2016

Eur Radiol

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Section: Discussionsupporting

confidence: 93%

“…This especially hampers the interpretation of the results regarding 3,5-T2, which cannot yet be related to serum concentrations of total and/or free T4 and T3, which are its putative precursors. However, the observed distinct patterns of the relationships between TSH and 3,5-T2 to AWT are in line with previous findings [23,34].…”

Section: Discussionsupporting

confidence: 92%

High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

Ittermann

Lorbeer²,

Dörr

et al. 2016

Eur Radiol

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“…However, interpretation of these findings on a mechanistic basis is not straightforward. Recently, nonlinear associations of serum 3,5-T 2 concentrations with altered microvascular damage parameters and glucose metabolism were observed in a subpopulation of the Study of Health in Pomerania (SHIP-2 and SHIP-Trend) [41,42]. …”

Section: Discussionmentioning

confidence: 99%

Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling

Dietrich¹,

Müller²,

Schiedat

et al. 2015

Eur Thyroid J

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Background: Although hyperthyroidism predisposes to atrial fibrillation, previous trials have suggested decreased triiodothyronine (T₃) concentrations to be associated with postoperative atrial fibrillation (POAF). Therapy with thyroid hormones (TH), however, did not reduce the risk of POAF. This study reevaluates the relation between thyroid hormone status, atrial electromechanical function and POAF. Methods: Thirty-nine patients with sinus rhythm and no history of atrial fibrillation or thyroid disease undergoing cardiac surgery were prospectively enrolled. Serum concentrations of thyrotropin, free (F) and total (T) thyroxine (T₄) and T₃, reverse (r)T₃, 3-iodothyronamine (3-T₁AM) and 3,5-diiodothyronine (3,5-T₂) were measured preoperatively, complemented by evaluation of echocardiographic and electrophysiological parameters of cardiac function. Holter-ECG and telemetry were used to screen for POAF for 10 days following cardiac surgery. Results: Seven of 17 patients who developed POAF demonstrated nonthyroidal illness syndrome (NTIS; defined as low T₃ and/or low T₄ syndrome), compared to 2 of 22 (p < 0.05) patients who maintained sinus rhythm. In patients with POAF, serum FT₃ concentrations were significantly decreased, but still within their reference ranges. 3,5-T₂ concentrations directly correlated with rT₃ concentrations and inversely correlated with FT₃ concentrations. Furthermore, 3,5-T₂ concentrations were significantly elevated in patients with NTIS and in subjects who eventually developed POAF. In multivariable logistic regression FT₃, 3,5-T₂, total atrial conduction time, left atrial volume index and Fas ligand were independent predictors of POAF. Conclusion: This study confirms reduced FT₃ concentrations in patients with POAF and is the first to report on elevated 3,5-T₂ concentrations in cardiac NTIS. The pathogenesis of NTIS therefore seems to involve more differentiated allostatic mechanisms.

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“…Previous studies have shown associations of 3,5-T 2 with atherosclerotic risk factors and endpoints [11, [13][14][15]24] . Particularly, a linkage of 3,5-T 2 with lipid and glucose metabolism was demonstrated in animal models [13][14][15] , which was confirmed for glucose but not for lipid metabolism in 1,000 humans of the SHIP-TREND study [11] .…”

Section: Discussionmentioning

confidence: 99%

Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies

Ittermann

Lorbeer

Tiller³

et al. 2015

Eur Thyroid J

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selected subpopulation of 750 individuals of SHIP-TREND, serum 3,5-T 2 concentrations were measured with a recently developed immunoassay. ABI was measured either by a hand-held Doppler ultrasound using the Huntleigh Dopplex D900 or palpatorily by the OMRON HEM-705CP device. Results: Serum TSH concentrations were not significantly associated with ABI values in any of the three studies. Likewise, groups of individuals with a TSH <0.3 mIU/l or with a TSH ≥ 3.0 mIU/l had no significantly different ABI values in comparison with individuals with a TSH in the reference range. Analyses regarding TSH within the reference range or serum 3,5-T 2 concentrations did not reveal consistent significant associations with the ABI. No sex-specific associations were detected. Conclusions: The results of our study do not substantiate evidence for an association between thyroid function and PAD, but further studies are needed to investigate the associations of overt forms of thyroid dysfunction with PAD. © 2015 European Thyroid Association Published by S. Karger AG, Basel Key WordsEpidemiology · Population-based study · Thyrotropin · Thyroid · Peripheral arterial disease · Ankle-brachial index Abstract Background: There is only limited data on the potential association between thyroid dysfunction and peripheral arterial disease (PAD). Objective: The aim of our study was to investigate the potential association of thyroid function, as defined by serum concentrations of the clinically used primary thyroid function marker thyrotropin [i.e. thyroid-stimulating hormone (TSH)] and 3,5-diiodothyronine (3,5-T 2 ), with the ankle-brachial index (ABI) as a marker of PAD. Methods: We used data from 5,818 individuals from three crosssectional population-based studies conducted in Northeast (SHIP-2 and SHIP-TREND) and Central Germany (CARLA). Measurement of serum TSH concentrations was conducted in one central laboratory for all three studies. In a randomly

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High Serum Thyrotropin Levels Are Associated with Retinal Arteriolar Narrowing in the General Population

Abstract: Our results substantiate evidence for an association between hypothyroidism and RAN. Potential mechanisms explaining this association are long-term hypertension, atherosclerotic processes, and inflammation.

Cited by 24 publications

References 39 publications

High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population

Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling

Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies

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