Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies

Ittermann, Till; Lorbeer, Roberto; Tiller, Daniel; Lehmphul, Ina; Kluttig, Alexander; Felix, Stephan B.; Werdan, Karl; Greiser, Karin Halina; Köhrle, Josef; Völzke, Henry; Dörr, Marcus

doi:10.1159/000381309

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…To calculate the ABI, the mean systolic BP of that ankle side which was lowest was divided by the brachial systolic BP which was the highest. Further details are described elsewhere [ 34 ]. In the third follow-up, the Vascular Explorer (VaE) (Fa.…”

Section: Study Design and Methodologymentioning

confidence: 99%

Cardiovascular risk factors, living and ageing in Halle: the CARLA study

et al. 2022

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The CARLA study (Cardiovascular Disease, Living and Ageing in Halle) is a longitudinal population-based cohort study of the general population of the city of Halle (Saale), Germany. The primary aim of the cohort was to investigate risk factors for cardiovascular diseases based on comprehensive cardiological phenotyping of study participants and was extended to study factors associated with healthy ageing. In total, 1779 probands (812 women and 967 men, aged 45–83 years) were examined at baseline (2002–2005), with a first and second follow-up performed 4 and 8 years later. The response proportion at baseline was 64.1% and the reparticipation proportion for the first and second follow-up was 86% and 77% respectively. Sixty-four percent of the study participants were in retirement while 25% were full- or partially-employed and 11% were unemployed at the time of the baseline examination. The currently running third follow-up focuses on the assessment of physical and mental health, with an intensive 4 h examination program, including measurement of cardiovascular, neurocognitive, balance and gait parameters. The data collected in the CARLA Study resulted in answering various research questions in over 80 publications, of which two thirds were pooled analyses with other similar population-based studies. Due to the extensiveness of information on risk factors, subclinical conditions and evident diseases, the biobanking concept for the biosamples, the cohort representativeness of an elderly population, and the high level of quality assurance, the CARLA cohort offers a unique platform for further research on important indicators for healthy ageing.

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Section: Study Design and Methodologymentioning

confidence: 99%

Cardiovascular risk factors, living and ageing in Halle: the CARLA study

et al. 2022

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Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism

Tamer,

Turan,

Taşkan

et al. 2024

Journal of Basic and Clinical Health Sciences

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Purpose: Subclinical thyroid diseases constitute the first stage of clinical thyroid, so it is important to investigate underlying mechanisms. Clinical studies have revealed changes in some adipokines concerning thyroid disorders. Relationship chemerin and vaspin adipokines with thyroid hormones are not clear. So, it was aimed to evaluate chemerin, vaspin, oxidative stress and inflammation markers in subclinical hypothyroidism/hyperthyroidism. Material and Methods: The study included 38 SubHyper, 31 SubHypo and 44 controls. Serum chemerin, vaspin, IL-10, CRP, and Ox-LDL were measured with ELISA, while TAS and TOS were spectrofometric method. Results: Serum chemerin were higher in SubHypo, while lower in SubHyper compared to controls. Vaspin levels of subclinical thyroid patients were lower than controls. IL-10 were lower in SubHyper; CRP were higher in both patient groups than controls. TAS were higher in SubHypo; TOS and OSI were lower in SubHyper patients. Conclusion: Increased total antioxidant and CRP in SubHypo and decreased total oxidants, IL-10 and OSI in SubHyper indicated that oxidant-antioxidant balance is impaired suggesting that subclinical thyroid diseases may cause changes in inflammation and defense mechanism. Decrease in chemerin in SubHyper and vaspin in SubHypo and SubHyper show that chemerin and vaspin may be candidates as biomarkers in subclinical thyroid diseases.

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Serum osteoprotegerin level in relation to ankle-brachial index among type 2 diabetic patients with subclinical hypothyroidism

Shoaeeb,

Atef,

Ezzat

et al. 2022

Tanta Medical Journal

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Background Osteoprotegerin (OPG) acts as an important regulatory molecule in vascular disease. The presence of diabetes mellitus greatly increases the risk of peripheral artery disease (PAD), and also both subclinical and overt hypothyroidism have been clearly linked with dyslipidemia, which is a known risk factor for peripheral arterial disease. Aim We aimed to evaluate the relation between serum OPG and PAD among type 2 diabetic patients with subclinical hypothyroidism (SCH). Patients and methods A total of 60 participants were enrolled in the study who were divided into three groups: group 1 included 20 type 2 diabetic patients with normal thyroid function, group 2 included 20 type 2 diabetic patients with SCH, and group 3 included 20 healthy participants. They were subjected to complete history taking, complete clinical examination, routine laboratory investigations, serum OPG level, neck ultrasound, and Doppler study for ankle-brachial index (ABI). Results We found that OPG levels were statistically elevated in type 2 diabetic patients with SCH group compared with type 2 diabetic patients with euthyroidism (P=0.040). Also there was lower ABI in type 2 diabetic patients with SCH compared with those with euthyroidism, showing an increased incidence of PAD in group 2 than group 1 and nondiabetic patients, with statistically significant results in between groups. Conclusions Our results found that diabetic patients with SCH revealed an independent association between thyroid-stimulating hormone and serum level of OPG. Likewise, we found a statistically significant difference between OPG level and ABI among type 2 diabetic patients. Therefore, OPG can act as a marker of PAD among diabetic patients with SCH.

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Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies

Cited by 3 publications

References 28 publications

Cardiovascular risk factors, living and ageing in Halle: the CARLA study

Cardiovascular risk factors, living and ageing in Halle: the CARLA study

Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism

Serum osteoprotegerin level in relation to ankle-brachial index among type 2 diabetic patients with subclinical hypothyroidism

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