High serum levels of HIF-1α in psoriatic patients correlate with an over-expression of IL-6

Vasilopoulos, Yiannis; Sourli, Fani; Zafiriou, Efterpi; Klimi, Eleni; Ιωάννου, Μαρία; Mamuris, Zissis; Simos, George; Koukoulis, Giorgos; Roussaki-Schulze, Angeliki

doi:10.1016/j.cyto.2013.02.029

Cited by 27 publications

(18 citation statements)

References 14 publications

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“…Particularly, it is increasingly expressed in inflammatory conditions such as psoriasis, in metabolic conditions such as obesity-associated insulin resistance [75,76]. In obesity setting, IL-6 expression mainly derives from adipose tissue, particularly from adipocytes and adipose tissue-derived macrophages, contributing 33% and 20%, respectively [67].…”

Section: Il-6mentioning

confidence: 99%

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

Chiricozzi

Raimondo

Lembo

et al. 2016

Expert Review of Clinical Immunology

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Psoriasis is a chronic skin disorder associated with several comorbid conditions. In psoriasis pathogenesis, the role of some cytokines, including TNF-α and IL-17, has been elucidated. Beside their pro-inflammatory activity, they may also affect glucose and lipid metabolism, possibly promoting insulin resistance and obesity. On the other hand, adipose tissue, secreting adipokines such as chemerin, visfatin, leptin, and adiponectin, not only regulates glucose and lipid metabolism, and endothelial cell function regulation, but it may contribute to inflammation. Areas covered: This review provides an updated 'state-of-the-art' about the reciprocal contribution of a small subset of conventional cytokines and adipokines involved in chronic inflammatory pathways, upregulated in both psoriasis and increased adiposity. A systematic search was conducted using the PubMed Medline database for primary articles. Expert commentary: Because psoriasis is associated with increased adiposity, it would be important to define the contribution of chronic skin inflammation to the onset of obesity and vice versa. Clarifying the pathogenic mechanism underlying this association, a therapeutic strategy having favorable effects on both psoriasis and increased adiposity could be identified.

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Section: Il-6mentioning

confidence: 99%

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

Chiricozzi

Raimondo

Lembo

et al. 2016

Expert Review of Clinical Immunology

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“…Because of the latter, IL-6 is known to be associated with chronic inflammation and related diseases. For example, elevated serum IL-6 levels have been detected in patients with systemic cancers, rheumatoid arthritis, systemic lupus erythematosus, psoriasis and Crohn’s disease as compared to healthy controls or patients with benign diseases [ 32 , 33 , 34 , 35 , 36 ]. It has been demonstrated that IL-6 is secreted by many types of cancer cells as it occurs in renal cell carcinoma.…”

Section: Cytokinesmentioning

confidence: 99%

Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases

Leyva‐López

Gutiérrez‐Grijalva

Ambriz-Pérez³

et al. 2016

IJMS

253

129

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High levels of cytokines, such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6, are associated with chronic diseases like rheumatoid arthritis, asthma, atherosclerosis, Alzheimer’s disease and cancer; therefore cytokine inhibition might be an important target for the treatment of these diseases. Most drugs used to alleviate some inflammation-related symptoms act by inhibiting cyclooxygenases activity or by blocking cytokine receptors. Nevertheless, these drugs have secondary effects when used on a long-term basis. It has been mentioned that flavonoids, namely quercetin, apigenin and luteolin, reduce cytokine expression and secretion. In this regard, flavonoids may have therapeutical potential in the treatment of inflammation-related diseases as cytokine modulators. This review is focused on current research about the effect of flavonoids on cytokine modulation and the description of the way these compounds exert their effect.

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“…For example, IL‐6 has been demonstrated to play a critical role in the pathogenesis of systemic sclerosis, an autoimmune connective tissue disorder characterized by fibrosis of the skin and internal organs [23]. Elevated IL‐6 levels were detected in serum and synovial tissues of patients with rheumatoid arthritis and also in the serum of patients with inflammatory disorders including asthma, psoriasis, inflammatory bowel disease, and Crohn's disease [24–28].…”

Section: Discussionmentioning

confidence: 99%

Role of interleukin‐6 and pentraxin 3 as an early marker in Peyronie's disease

Atar

Kural

Yenice

et al. 2017

The Kaohsiung J of Med Scie

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Inflammation is mechanistically involved in the development of Peyronie's disease (PD). The aim of this study is to assess the relevance of serum pentraxin 3 (PTX3) and interleukin-6 (IL-6) concentrations in PD. The study enrolled 40 patients with PD in the acute phase and 40 healthy controls. Plasma PTX3 and IL-6 concentrations were evaluated in 40 patients in the acute phase of PD and 40 healthy controls by enzyme-linked immunosorbent assay. Serum concentrations of both PTX3 and IL-6 were significantly higher in the PD patients than in the control group (p=0.001 and p=0.001, respectively). There was a significant correlation between concentration of PTX3 and painful erections. IL-6 concentrations were significantly higher in patients with erectile dysfunction. IL-6 and PTX3 levels showed no correlation with age, serum C-reactive protein, degree of curvature, and disease duration. IL-6 trans-signaling and PTX3 amplification at the site of inflammation could have a role in pathophysiological mechanisms of PD. Biological drugs may be used for treatment during the acute phase of the disease based on this mechanism.

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High serum levels of HIF-1α in psoriatic patients correlate with an over-expression of IL-6

Cited by 27 publications

References 14 publications

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases

Role of interleukin‐6 and pentraxin 3 as an early marker in Peyronie's disease

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