High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

Liu, Zhihua; Cai, Yan; He, Jincai

doi:10.2147/ndt.s155144

Cited by 30 publications

(23 citation statements)

References 49 publications

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“…27 Several studies have reported that free radicals are also involved in depression pathophysiology. 17,28,29 This study observed higher MDA levels in the depressed post-stroke group compared to the group without depression (p = 0.024). This is due to the vulnerability of brain tissue to oxidative stressors, given its high oxygen consumption and the high PUFA content of brain tissue.…”

Section: Discussionmentioning

confidence: 55%

“…12,30,31 Liu's study also found that elevated 8-OhdG in the acute phase was correlated with one-month poststroke depression. 29 These arguments imply that peripheral 8-OhdG levels can serve as an indicator of the oxidative process in the brain. 30 In this study, it was found that MDA serum level was significantly higher in the post-stroke depression group than in the non-depression group (p=0.024).…”

Section: Discussionmentioning

confidence: 99%

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Relationship of brain-derived neurotrophic factor, malondialdehyde, and 8-Hydroxy 2-Deoxyguanosine with post-ischemic stroke depression

Syafrita

Amir²,

Susanti

et al. 2020

Dement. neuropsychol.

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A few studies have shown that serum brain-derived neurotrophic factor (BDNF) level in post-stroke depression is highly correlated with memory and neuropsychiatric disturbances. Objective: This study aimed to elucidate the relationship of serum BDNF, malondialdehyde (MDA), and 8-Hydroxy 2-Deoxyguanosine (8-OhdG) levels in acute stroke cases with one-month post-stroke depression. Methods: An observational study was conducted of 72 post-ischemic stroke patients in the Neurology ward of the Dr. M. Djamil Hospital, Padang, West Sumatra, Indonesia. Acute stroke (< 48 hours) serum BDNF, MDA, and 8-OhdG levels were measured using ELISA. Based on observations using the Hamilton Depression Rating Scale conducted one month after stroke, respondents were divided into two groups: with and without depression. The mean serum level was analyzed using the t-test and Mann-Whitney test, while differences in basic characteristics were analyzed using the Chi-square test. Multivariate analysis was conducted to determine the most significant factor associated with post-stroke depression. The error rate was set at 5%. Results: BDNF levels in acute stroke were significantly lower in the depression group than in the non-depression group (p < 0.05). MDA and 8-OhdG levels in acute stroke were higher in the depression group (p < 0.05). BDNF level during acute stroke was negatively correlated with post-stroke depression, while, conversely, acute stroke MDA and 8-OhdG levels were positively correlated with depression. Conclusion: BDNF had a negative correlation, while MDA and 8-OhdG had a positive correlation, with depression one-month post-stroke. 8-OhdG was the most influential factor in post-stroke depression.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Relationship of brain-derived neurotrophic factor, malondialdehyde, and 8-Hydroxy 2-Deoxyguanosine with post-ischemic stroke depression

Syafrita

Amir²,

Susanti

et al. 2020

Dement. neuropsychol.

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“…In the study conducted by Liu et al [26], 241 ischemic stroke patients were consecutively recruited within the first 24h of stroke symptom onset and were followed up at 1 month. Serum 8-OHdG and catalase (CAT) levels were measured within 24h of hospital admission.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of brain ischemia-reperfusion injury after carotid endarterectomy

et al. 2022

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Introduction: Endarterectomy of the internal carotid artery (CEA) is a surgical procedure used to prevent cerebral ischemic stroke. Available data from previous literature indicates that CEA may lead to complications in the form of cerebral ischemia-reperfusion syndrome and oxidative stress. The aim of this study was to evaluate the serum levels of oxidative stress-related biomarkers such as 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA) in patients who underwent CEA. Material and methods: Twenty-four patients with severe internal carotid artery stenosis participated in the study. Serum samples were taken from patients at three different times: within 24 hours preoperatively to CEA, 12 hours postoperatively, and 48 hours postoperatively. Serum 8-OHdG and MDA levels were measured using a commercially available enzyme-linked immunosorbent assay. Results: Serum 8-OHdG levels indicated statistically significant elevation 12 hours after surgery when compared to preoperative levels (p < 0.05). A further increase in the concentration of this parameter was observed 48 hours after surgery when compared to the previous measurement, however, this increase was no longer statistically significant (p = 0.05). Furthermore, serum MDA levels also indicated a statistically significant elevation 48 hours after surgery when compared to preoperative levels (p < 0.05). Conclusion: Our study showed that CEA causes an increase in blood levels of 8-OHdG and MDA, which may be related to the occurrence of oxidative stress during cerebral ischemia-reperfusion injury. Therefore, 8-OHdG and MDA may represent corresponding markers of cerebral ischemia-reperfusion complications in patients undergoing CEA.

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“…Meanwhile, T2DM patients usually suffer from a variety of mental health problems 4. Depression, a common mental disorder, is also a common complication of stroke 5. Nowadays, poststroke depression (PSD) has become a serious problem for T2DM patients.…”

Section: Introductionmentioning

confidence: 99%

<p>Urinary biomarkers for diagnosing poststroke depression in patients with type 2 diabetes mellitus</p>

Liang¹,

Jia²,

Li³

et al. 2019

DMSO

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Background Depression can seriously affect the quality of life of type 2 diabetes mellitus (T2DM) patients after stroke. However, there were still no objective methods to diagnose T2DM patients with poststroke depression (PSD). Therefore, we conducted this study to deal with this problem. Methods Gas chromatography-mass spectroscopy (GC-MS)-based metabolomics profiling method was used to profile the urinary metabolites from 83 nondepressed T2DM patients after stroke and 101 T2DM patients with PSD. The orthogonal partial least-squares discriminant analysis was conducted to explore the metabolic differences in T2DM patients with PSD. The logistic regression analysis was performed to identify the optimal and simplified biomarker panel for diagnosing T2DM patients with PSD. The receiver operating characteristic curve analysis was used to assess the diagnostic performance of this biomarker panel. Results In total, 23 differential metabolites (7 decreased and 16 increased in T2DM patients with PSD) were found. A panel consisting of pseudouridine, malic acid, hypoxanthine, 3,4-dihydroxybutyric acid, fructose and inositol was identified. This panel could effectively separate T2DM patients with PSD from nondepressed T2DM patients after stroke. The area under the curve was 0.965 in the training set and 0.909 in the validation set. Meanwhile, we found that the galactose metabolism was significantly affected in T2DM patients with PSD. Conclusion Our results could be helpful for future development of an objective method to diagnose T2DM patients with PSD and provide novel ideas to study the pathogenesis of depression.

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High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

Cited by 30 publications

References 49 publications

Relationship of brain-derived neurotrophic factor, malondialdehyde, and 8-Hydroxy 2-Deoxyguanosine with post-ischemic stroke depression

Relationship of brain-derived neurotrophic factor, malondialdehyde, and 8-Hydroxy 2-Deoxyguanosine with post-ischemic stroke depression

Biomarkers of brain ischemia-reperfusion injury after carotid endarterectomy

<p>Urinary biomarkers for diagnosing poststroke depression in patients with type 2 diabetes mellitus</p>

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