High-sensitivity sensor based on surface plasmon resonance and heterodyne interferometry

Wu, Chien‐Ming; Jian, Zhi-Cheng; Joe, Shen-Fen; Chang, Liann‐Be

doi:10.1016/s0925-4005(03)00157-6

Cited by 84 publications

(44 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sensitivity as high as 5×10 −7 RIU has been predicted. Wu et al [92] proposed a simpler setup as shown in Fig. 7 where two AOMs with driving frequency of 40 and 40.06 MHz were used to directly create a beat frequency of 60 kHz.…”

Section: Optical Heterodynementioning

confidence: 99%

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

View full text Add to dashboard Cite

International audienceSurface Plasmon Resonance (SPR) has become a central tool for label-free characterization of biomolecular interactions. Based on monitoring of amplitude characteristics, conventional SPR sensors have been extensively explored, commercialized and applied for studies of many important interactions (antigen-antibody, protein-ligand etc), but this technology still lacks of sensitivity for the detection of relatively small and low copy number compounds. Phase-sensitive SPR has recently emerged as an upgrade of this technology to resolve the sensitivity issue. Profiting from a sharp phase jump under SPR and ultra-sensitive tools of its control, this technology offers up to 100-time improvement of the detection limit, giving access to the detection of trace amounts of small molecular weight analytes (drugs etc). This paper intends to provide a tutorial on basic concepts of phase detection in SPR sensing, compare the performance of phase- and amplitude-sensitive sensors, review recent progress in the development and applications of phase-sensitive SPR sensors, and outline future prospects and trends of this technology

show abstract

Section: Optical Heterodynementioning

confidence: 99%

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Following that, Xinglong et al introduced a transverse Zeeman laser as the light source, which includes both p-and s-polarized light, and demonstrated a heterodyne phase detection SPR sensor for immunosensing [34]. Later on, Wu et al reported another similar heterodyne phase detection sensor and pushed the sensitivity to 2 × 10 −7 RIU [35]. Subsequently, by integrating the features of a common-path optical heterodyne interferometer and the amplitude-ratio detection mode, Chou et al developed a paired surface plasma wave biosensor that had achieved a record-high detection sensitivity of up to 10 −9 RIU [36,37].…”

Section: Phase Interrogation Sprmentioning

confidence: 99%

Recent advances in surface plasmon resonance imaging: detection speed, sensitivity, and portability

et al. 2017

View full text Add to dashboard Cite

Surface plasmon resonance (SPR) biosensor is a powerful tool for studying the kinetics of biomolecular interactions because they offer unique real-time and label-free measurement capabilities with high detection sensitivity. In the past two decades, SPR technology has been successfully commercialized and its performance has continuously been improved with lots of engineering efforts. In this review, we describe the recent advances in SPR technologies. The developments of SPR technologies focusing on detection speed, sensitivity, and portability are discussed in details. The incorporation of imaging techniques into SPR sensing is emphasized. In addition, our SPR imaging biosensors based on the scanning of wavelength by a solid-state tunable wavelength filter are highlighted. Finally, significant advances of the vast developments in nanotechnology-associated SPR sensing for sensitivity enhancements are also reviewed. It is hoped that this review will provide some insights for researchers who are interested in SPR sensing, and help them develop SPR sensors with better sensitivity and higher throughput.

show abstract

“…This type of sensing scheme has been developed and applied to the SPR-based sensors. Wu et al combined acousto-optomodulators (AOMs) with a common path heterodyne interferometer [71]. One of the AOMs can be excited at 40 MHz and another at 40.06 MHz in order to induce two linearly orthogonally polarized beams with a frequency difference of 60 kHz.…”

Section: Phase-interrogated Resonance-based Sensorsmentioning

confidence: 99%

Optical integrated chips with micro and nanostructures for refractive index and SERS-based optical label-free sensing

et al. 2015

View full text Add to dashboard Cite

Label-free optical biosensing technologies have superior abilities of quantitative analysis, unmodified targets, and ultrasmall sample volume, compared to conventional fluorescence-label-based sensing techniques, in detecting various biomolecules. In this review article, we introduce our recent results in the field of evanescent-wavebased refractive index sensing and surface enhanced Raman scattering (SERS)-based sensing, both of which are promising platforms for label-free optical biosensors. First, silicon-on-insulator (SOI) nanowire waveguide and metallic surface plasmon resonance (SPR)-based refractive index sensing are discussed. In order to improve the detection limit, phase interrogation techniques are introduced to these types of sensors based on prism-coupled SPR and SOI microring resonators. A detection limit in the order of 10 −6 refractive index unit is achieved. Detection of 16.7 pM anti-IgG is also demonstrated based on the SPR devices. Second, SERS substrates based on various nanometallic structures are discussed. Metallic nanowire arrays and inverted nanopyramids and grooves with a thin metal surface are fabricated based on anisotropic wetetching of silicon substrates. Both structures have demonstrated a Raman signal enhancement on the order of 10 7 .In order to improve the extraction efficiency of the Raman signal at a high wave number, a nano-bowtie array substrate is fabricated, which exhibits double resonances at both the excitation wavelength and the desired Raman scattering wavelength. Experimental results have shown that this double-resonance structure can further enhance the received Raman signal, as compared to conventional SERS substrates with only one resonance at the excitation wavelength.

show abstract

High-sensitivity sensor based on surface plasmon resonance and heterodyne interferometry

Cited by 84 publications

References 12 publications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Recent advances in surface plasmon resonance imaging: detection speed, sensitivity, and portability

Optical integrated chips with micro and nanostructures for refractive index and SERS-based optical label-free sensing

Contact Info

Product

Resources

About