Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Huang, Yuanhao; Ho, Ho Pui; Kong, Siu Kai; Kabashin, Andrei V.

doi:10.1002/andp.201200203

Cited by 119 publications

(72 citation statements)

References 121 publications

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“…However, it has recently been proposed that the phase information contained in light scattered or reflected from nanoparticles excited at resonance could be used to implement alternative and even more effective LSPR sensing schemes. [6][7][8][9][10][11] Indeed, phase interrogation techniques have significantly decreased the limits of detection in the case of classical surface plasmon resonance sensors based on planar gold films. 7,[12][13][14] In this case, the sensitivity enhancement is primarily due to the rapid phase flip that occurs when the reflectance approaches zero close to the resonance wavelength.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10][11] Indeed, phase interrogation techniques have significantly decreased the limits of detection in the case of classical surface plasmon resonance sensors based on planar gold films. 7,[12][13][14] In this case, the sensitivity enhancement is primarily due to the rapid phase flip that occurs when the reflectance approaches zero close to the resonance wavelength. Similar properties have been observed in studies of collective resonances in periodic arrays of nanoparticles, 8,9 which experienced high bulk refractive index sensitivities due to sharp diffractive resonances in combination with zero reflection, or so-called 'topological darkness', a term coined by Kravets et al 8,15 However, large bulk refractive index sensitivities do not directly lead to high sensitivity to molecular adsorption in close proximity to the metal surface.…”

Section: Introductionmentioning

confidence: 99%

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Refractometric biosensing based on optical phase flips in sparse and short-range-ordered nanoplasmonic layers

2014

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Noble metal nanoparticles support localized surface plasmon resonances (LSPRs) that are extremely sensitive to the local dielectric properties of the environment within distances up to 10-100 nm from the metal surface. The significant overlap between the sensing volume of the nanoparticles and the size of biological macromolecules has made LSPR biosensing a key field for the application of plasmonics. Recent advancements in evaluating plasmonic refractometric sensors have suggested that the phase detection of light can surpass the sensitivity of standard intensity-based detection techniques. Here, we experimentally confirm that the phase of light can be used to precisely track local refractive index changes induced by biomolecular reactions, even for dilute and layers of short-range-ordered plasmonic nanoparticles. In particular, we demonstrate that the sensitivity can be enhanced by tuning in to a zero reflection condition, in which an abrupt phase flip of the reflected light is achieved. Using a cost-effective interference fringe tracking technique, we demonstrate that phase measurements yield an approximately one order of magnitude larger relative shift compared with traditional LSPR measurements for the model system of NeutrAvidin binding to biotinylated nanodisks.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Refractometric biosensing based on optical phase flips in sparse and short-range-ordered nanoplasmonic layers

2014

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“…The intrinsic MO activity of gold nanodisks was measured along the symmetry axis. Compared to the transmittance spectra, the MO spectra shows a much narrower line width, namely a higher quality factor which suggests characterizing the MO activity might be a promising method for refractive index sensing using plasmonic nanostructures [18][19][20][21]. …”

Section: Resultsmentioning

confidence: 99%

The effect of shape anisotropy on the spectroscopic characterization of the magneto-optical activity of nanostructures

Saito

Takahashi

2013

Journal of Applied Physics

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Abstract：How to measure magnetic field induced magneto-optical (MO) activity of nonmagnetic elliptical plasmonic nanodisks which rest on a dielectric substrate remains a challenge since the substrate contribute most of the overall MO which varies with light polarization with respect to the orientation of the nanodisks. Here we present a spectroscopic characterization. We find that only when light is incident from the nanostructures' side with polarization aligned with one of the two symmetry axes, one can subtract the MO contribution from the substrate by an amount equal to that of a bare one. By a detailed polarizing transmittance measurement we determine the orientation of the two symmetry axes of the nanodisks. Light polarization is then aligned along the axes, enabling measurement of the intrinsic MO activity of gold nanodisks, which is the overall MO activity subtracted by that of a bare glass substrate. The narrow line widths of the plasmonic resonance features in the MO spectra imply a potential application in refractive index sensing.

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“…It is important to note that the resulting QW-SPR sensitivities are found to be comparable to the best reported in the SPR literature. 27,28 The specific immobilization and detection of the IAV-H3N2 has demonstrated the potential to use the QW-SPR device as an active biosensor. The challenges in detecting IAV in solution with SPR lies in both the chemistry involved and the small RIU changes induced.…”

Section: Discussionmentioning

confidence: 99%

Real-time detection of influenza A virus using semiconductor nanophotonics

et al. 2013

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Modern miniaturization and the digitalization of characterization instruments greatly facilitate the diffusion of technological advances in new fields and generate innovative applications. The concept of a portable, inexpensive and semi-automated biosensing platform, or lab-on-a-chip, is a vision shared by many researchers and venture industries. Under this scope, we present a semiconductor monolithic integration approach to conduct surface plasmon resonance studies. This technology is already commonly used for biochemical characterization in pharmaceutical industries, but we have reduced the technological platform to a few nanometers in scale on a semiconductor chip. We evaluate the signal quality of this nanophotonic device using hyperspectral-imaging technology, and we compare its performance with that of a standard prism-based commercial system. Two standard biochemical agents are employed for this characterization study: bovine serum albumin and inactivated influenza A virus. 2 However, the delocalization of arbitrary biochemical analyses is still a challenge today, where nanotechnogy could present solutions for the development of micro total analysis systems (mTAS) potentially capable of portable biodiagnostics. 3 We present here the results of an effort towards such a solution through a wholly integrated semiconductor-based surface plasmon resonance (SPR) nanometric platform.SPR is a well-established optical phenomenon where an electromagnetic (EM) beam of a specific energy and incident wavevector (angle) can induce a resonant group oscillation within the surface electrons of a metal-dielectric interface. 4 The resulting EM field is evanescent in nature, with typical confinement of 200 nm for visible light. Therefore, the coupling conditions of this resonance effect are very much dictated by the surface conditions within the evanescent field and can consequently be employed for many dynamic biochemistry studies. 5 The SPR biocharacterization platform presents many advantages over most other methods; its range of application is very broad, especially for unspecific binding studies, 5 the method can offer very high sensitivities to subtle surface refractive index changes 6 and even enable

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Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Cited by 119 publications

References 121 publications

Refractometric biosensing based on optical phase flips in sparse and short-range-ordered nanoplasmonic layers

Refractometric biosensing based on optical phase flips in sparse and short-range-ordered nanoplasmonic layers

The effect of shape anisotropy on the spectroscopic characterization of the magneto-optical activity of nanostructures

Real-time detection of influenza A virus using semiconductor nanophotonics

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