High-sensitivity extended-gate field-effect transistors as pH sensors with oxygen-modified reduced graphene oxide films coated on different reverse-pyramid silicon structures as sensing heads

Li, Yu Ren; Chang, Shih Hsueh; Chang, Chia Tsung; Tsai, Wan Lin; Chiu, Yu Kai; Yang, Po Chih; Cheng, Hsiu‐Fung

doi:10.7567/jjap.55.04em08

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…The normalized resistance (ΔR/R0) to the rGO resistance in air (R0 ~6.7 KΩ) decreased for unitary changes of pH from 3 to 8 with a sensitivity of 0. 4c) 104,105 . After spraying a commercial rGO solution onto the substrate and heating at 120 °C, the rGO was annealed in nitrogen at 300 °C for 1h and treated with oxygen plasma for 1 min.…”

Section: Reduced Graphene Oxidementioning

confidence: 99%

Graphene-based devices for measuring pH

Salvo

Melai

Calisi

et al. 2018

Sensors and Actuators B: Chemical

123

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pH measuring and monitoring is fundamental to understand or control many chemical processes in biological, industrial or environmental fields. Potentiometric measurements by a glass electrode is the most common method to measure pH, although single-use paper strips are also widely used. Other methods include the use of hydrogen, quinhydron, and antimony electrodes, the imaging using pH-sensitive indicators such as dyes or proteins, and the use of ion-selective field effect transistor (ISFET). Due to the chemical reactivity of both sides of its 2D structure, nanometer thickness, high electron mobility, high reactivity to oxygen groups such as OH-, and ultrafast optical response, graphene has the potential to be used for the fabrication of nanoscale, wide-range, high-sensitivity and flexible pH sensors. This review describes how graphene, graphene oxide and reduced graphene oxide can be used to fabricate pH-sensitive devices (e.g. solution-gated FETs, solid-gate FETs, electrochemical sensors, and pH-sensitive quantum dots). The various configurations are reported along with the advantages and current limitations

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Section: Reduced Graphene Oxidementioning

confidence: 99%

Graphene-based devices for measuring pH

Salvo

Melai

Calisi

et al. 2018

Sensors and Actuators B: Chemical

123

View full text Add to dashboard Cite

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“…The 2D structure offered by the rGO layer is only confined to the solution interface on the FG by the SiO 2 insulator, which preserves the high surface-to-volume ratio for the sensing section. In contrast, it is challenging to avoid any influences of the bulk electrode underneath rGO layers for resistive connections of rGO layer , utilized in the conventional RGFET (Figure b) since the rGO layer is electrically coupled to the bulk electrode. That is, rGO and electrode complexes are regarded as a single combined resistor under the solution contact for a conventional RGFET, losing structural advantages offered by rGO layers at the solution interfaces.…”

Section: Results and Discussionmentioning

confidence: 99%

Remote Floating-Gate Field-Effect Transistor with 2-Dimensional Reduced Graphene Oxide Sensing Layer for Reliable Detection of SARS-CoV-2 Spike Proteins

Jang

Sui

Zhuang

et al. 2022

ACS Appl. Mater. Interfaces

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Despite intensive research of nanomaterials-based field-effect transistors (FETs) as a rapid diagnostic tool, it remains to be seen for FET sensors to be used for clinical applications due to a lack of stability, reliability, reproducibility, and scalability for mass production. Herein, we propose a remote floating-gate (RFG) FET configuration to eliminate device-to-device variations of twodimensional reduced graphene oxide (rGO) sensing surfaces and most of the instability at the solution interface. Also, critical mechanistic factors behind the electrochemical instability of rGO such as severe drift and hysteresis were identified through extensive studies on rGO−solution interfaces varied by rGO thickness, coverage, and reduction temperature. rGO surfaces in our RFGFET structure displayed a Nernstian response of 54 mV/pH (from pH 2 to 11) with a 90% yield (9 samples out of total 10), coefficient of variation (CV) < 3%, and a low drift rate of 2%, all of which were calculated from the absolute measurement values. As proof-of-concept, we demonstrated highly reliable, reproducible, and label-free detection of spike proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a saliva-relevant media with concentrations ranging from 500 fg/mL to 5 μg/mL, with an R 2 value of 0.984 and CV < 3%, and a guaranteed limit of detection at a few pg/mL. Taken together, this new platform may have an immense effect on positioning FET bioelectronics in a clinical setting for detecting SARS-CoV-2.

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“…Then, it was found that for the In addition, IR sensing [305,306], pH sensing [307,308] and ion sensing [262,309] of GObased FETs were also reported. Trung et al [305] demonstrated the IR sensing ability of RGO FETs, which exhibited high sensitivity and reproducibility even with a temperature interval of 1 K. Then, high pH sensitivity of 57.5 mV/pH and excellent linearity of 0.9929 in a wide pH sensing range of 1-13 were achieved in the RGO-based FETs using an oxygen plasma treatment to increase the functional groups on the RGO films [308]. Besides, high sensitivity and excellent lower detection limit of 1 nM for real-time detection of Hg 2+ in an underwater environment were also obtained in the RGO-based FETs [262].…”

Section: Field-effect Transistors (Fets)mentioning

confidence: 99%

Physical properties and device applications of graphene oxide

2020

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Graphene oxide (GO), the functionalized graphene with oxygenated groups (mainly epoxy and hydroxyl), has attracted resurgent interests in the past decade owing to its large surface area, superior physical and chemical properties, and easy composition with other materials via surface functional groups. Usually, GO is used as an important raw material for mass production of graphene via reduction. However, under different conditions, the coverage, types, and arrangements of oxygencontaining groups in GO can be varied, which give rise to excellent and controllable physical properties, such as tunable electronic and mechanical properties depending closely on oxidation degree, suppressed thermal conductivity, optical transparency and fluorescence, and nonlinear optical properties. Based on these outstanding properties, many electronic, optical, optoelectronic, and thermoelectric devices with high performance can be achieved on the basis of GO. Here we present a comprehensive review on recent progress of GO, focusing on the atomic structures, fundamental physical properties, and related device applications, including transparent and flexible conductors, field-effect transistors, electrical and optical sensors, fluorescence quenchers, optical limiters and absorbers, surface enhanced Raman scattering detectors, solar cells, light-emitting diodes, and thermal rectifiers.

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High-sensitivity extended-gate field-effect transistors as pH sensors with oxygen-modified reduced graphene oxide films coated on different reverse-pyramid silicon structures as sensing heads

Cited by 8 publications

References 33 publications

Graphene-based devices for measuring pH

Graphene-based devices for measuring pH

Remote Floating-Gate Field-Effect Transistor with 2-Dimensional Reduced Graphene Oxide Sensing Layer for Reliable Detection of SARS-CoV-2 Spike Proteins

Physical properties and device applications of graphene oxide

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