High Sensitivity C-Reactive Protein as Atherogenic Marker Among Type 2 Diabetes

Abstract

Background: People with type 2 diabetes are threefold affected by cardiovascular disease (CVD) compared with non-diabetics. Many studies reported the absence of traditional CVD risk factors in a substantial portion of individuals experiencing clinical vascular events. Novel risk markers for CVD are often said to add independent predictive value for risk prediction. Objective: In the present study we evaluated different CVD risk factors based on high-sensitivity C-reactive (hs-CRP) protein quartiles among diabetics and non-diabetics population. Methods: In this population-based cross-sectional study, we recruited a total of one-hundred and nine participants (64 type 2 diabetics and 45 healthy controls). Venous blood sample collected from each subject. Body weight and height were measured and body mass index (BMI) was calculated. Biochemical analytes were measured according to standard procedures. Data analyzed using SPSS software. Results: Mean serum hs-CRP levels were significantly higher among diabetics (2.3 mg/l) compared to controls (1.8 mg/l; P = 0.019). Moreover, the 3rd & 4th quartiles of hs-CRP were characterized by more frequency of diabetes as well as hypertension. The percent of participants with diabetes or hypertension seemed positively related to hs CRP concentrations. Lipid profile analysis revealed the highest levels of LDL-C and Apo B in 4th quartile hs-CRP. In addition, participants in the 4th quartile hs-CRP were characterized by the highest age, BMI, plasma glucose. However, there was no clear association between levels of hs-CRP and the HbA1c, TC, TG, HDL-C, and Apo A1.European Scientific Journal November 2017 edition Vol.13, No.33 ISSN: 1857 -7881 (Print) e -ISSN 1857 404 Conclusion: Measurement of hs-CRP in diabetic patients might provide useful information for development of atherosclerosis and cardiovascular disease and help in early intervention.

Glycaemic control and C- reactive protein levels in type 2 diabetes mellitus -how well they co-relate?: a prospective study

“…19 The mean hsCRP levels in the study population at baseline was 7.85±9.75 mg/l which is in accordance to that observed in another Indian study conducted in Bangalore (6.9±9.3 mg/l); while Saudi Arabian and Bangladesh studies had shown mean hsCRP levels lower than that observed in the present study, 1.13 and 2.3 mg/L respectively. 6,18 The reason for this difference in CRP levels is unclear; further studies are needed to assess the differences in ethnic groups; standardisation of the techniques used for measurement of hsCRP.…”

“…[14][15][16] while some failed to do so. 6 Also, the effect of good glycaemic control on CRP levels is not clear. The aim of this study is to determine the co-relation of glycaemic control as measured by HbA1c levels with hsCRP in patients with type 2 diabetes mellitus and to determine if better glycaemic control reduces CRP levels.…”

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

“…Similarly, in a recent study, Cheng et al, [22], observed that long term inflammation mediated by inflammatory markers such as C -reactive protein was due to increase in body mass, waist circumference that plays a role in development of type 2 diabetes. Mohiedelin et al, [23] reported significant elevated level of high sensitive C -reactive (Hs-CRP) due to dysregulation of glucose and lipid metabolism which affect endothelial function that was associated with cardiovascular diseases in type 2 diabetes. Babu and Joshi [24] reported that significant high level of C-reactive is associated with microvascular complication due to production of pro inflammatory cytokines released by adipose decreases beta cell mass through interleukin 1β induced apoptosis.…”

Study to Determine the Relation Between Hba1c, Lipid Profile and CRP in Individuals With Type 2 Diabetes Mellitus in a Tertiary Care Hospital

“…3,4 It is an important predictor of cardiovascular risk apart from the traditional risk factors. 5,6 It is interesting to note that chronic hyperglycaemia stimulates the release of various inflammatory cytokines (IL 6; TNF α) and induces the secretion of acute phase reactants by liver, which in turn results in elevation of CRP in association with elevated fasting plasma glucose. 7 Studies had shown that elevated CRP levels is associated with an increased risk of future development of diabetes mellitus.…”

“…[14][15][16] while some failed to do so. 6 Also, the effect of good glycaemic control on CRP levels is not clear. The aim of this study to determine the relation between HbA1C, Lipid profile and CRP in individuals with type 2 diabetes mellitus.…”