Glycaemic control and C- reactive protein levels in type 2 diabetes mellitus -how well they co-relate?: a prospective study

Petchiappan, Velammal; Sivakrishna, Nanubala; Manickam, Santni; Menon, Sujaya

doi:10.18203/2320-6012.ijrms20191683

Cited by 3 publications

(5 citation statements)

References 13 publications

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“…These above results suggest that elevated CRP levels are related to worsening of glycemic control. These findings are in agreement with the findings of Petchiappan et al 27 The correlation between CRP and albuminuria was a statistically positive strong correlation with a ρ value of 0.831 and a p value of 0.00. This is in line with studies Kahraman C and Navarro JF.…”

Section: Discussionsupporting

confidence: 93%

Study of association between C-reactive protein and albuminuria in type 2 diabetes mellitus

Rastogi,

Kumar,

Rastogi

et al. 2023

Int J Res Med Sci

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Background: Inflammatory markers are excessively produced by adipocytes in T2DM due to obesity-induced dysregulation of adipocytes. Inflammation is recognised by elevated level of inflammatory markers like C-reactive protein. It has been reported that patients with nephropathy and those with albuminuria have higher levels of inflammatory markers. Methods: Study design observational descriptive cross-sectional study. 150 subjects having age more than 30 years and less than 55 years diagnosed with type 2 diabetes mellitus were included. HbA1c, FPG, creatinine, urea, CRP, and albuminuria were analysed. Results: A strong and statistically significant correlation was seen between serum CRP levels and albuminuria levels with a p value of 0.831 and a p value of 0.00. The study group was divided into two groups with normal CRP (n=40) and elevated CRP (n=110). Average values of all parameters showed a statistically significant increase in the group with abnormal CRP levels. In the ROC analysis, an area of .957 under the curve shows a very high predictive value of 15.5 mg/l of CRP for predicting albuminuria in patients of T2DM. Conclusions: From our results, we have been able to establish a strong association as well as a predictive relationship between the level of CRP and albuminuria in T2DM. We have shown that serum CRP levels at a cut-off of 15.5 mg/l are a predictor of clinically significant albuminuria. This makes serum CRP level an effective screening tool for albuminuria.

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Section: Discussionsupporting

confidence: 93%

Study of association between C-reactive protein and albuminuria in type 2 diabetes mellitus

Rastogi,

Kumar,

Rastogi

et al. 2023

Int J Res Med Sci

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“…9 Kadar glukosa darah yang tinggi dalam jangka waktu lama (hiperglikemia kronik), menstimulasi sekresi dari berbagai sitokin inflamasi termasuk IL-6, IL-1, dan TNF-yang berakibat pada peningkatan kadar C-reactive protein (CRP). 10 C-reactive protein merupakan protein fase akut yang diproduksi oleh hepar. Kadar CRP yang meningkat menunjukkan bahwa terdapat inflamasi di dalam tubuh, sehingga CRP sering digunakan sebagai penanda inflamasi.…”

Section: Pendahuluanunclassified

“…Penelitian tersebut menyatakan bahwa tidak terdapat hubungan yang signifikan antara kadar HbA1c dengan kadar CRP pada pasien diabetes melitus tipe 2 pada keadaan metabolisme basal (p=0,10, r=0,32). 10 Hasil penelitian ini berbeda dengan beberapa penelitian sebelumnya. Hasil penelitian yang dilakukan oleh Sasidharan et al pada tahun 2016 menyatakan bahwa terdapat hubungan positif antara kadar HbA1c dengan kadar CRP (p=0,00, r=0,66).…”

Section: Hubungan Kadar Hba1c Dengan Kadar Crp Pada Penderita Diabetes Melitus Tipe 2 Dengan Obesitas Dan Tanpa Obesitasunclassified

HUBUNGAN HbA1c DENGAN CRP PADA PENDERITA DIABETES MELITUS TIPE-2 DENGAN OBESITAS DAN TANPA OBESITAS

et al. 2020

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Latar belakang: Diabetes melitus merupakan penyakit inflamasi kronis yang ditandai dengan peningkatan kadar glukosa plasma. Kadar glukosa plasma yang tinggi dalam jangka waktu lama (hiperglikemia kronik), menstimulasi peningkatan kadar C-reactive protein (CRP). Penderita DMT2 dengan obesitas kemungkinan memiliki kadar CRP yang lebih tinggi karena penumpukan sel adiposa juga dapat memicu reaksi inflamasi di dalam tubuh. Mengetahui hubungan antara obesitas, DMT2, dan kadar CRP sangat diperlukan untuk tujuan klinis serta mencegah terjadinya komplikasi penyakit.Tujuan: Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara kadar HbA1c dan CRP pada penderita diabetes melitus tipe 2 dengan obesitas dan tanpa obesitasMetode: Penelitian observasional analitik dengan pendekatan belah lintang dilakukan di Rumah Sakit Nasional Diponegoro dan beberapa klinik pratama di Semarang pada Mei-Juli 2020. Subjek penelitian adalah 30 penderita diabetes melitus tipe 2 dengan obesitas dan 30 penderita diabetes melitus tipe 2 tanpa obesitas usia 35-60 tahun Pengukuran kadar HbA1c dan CRP dilakukan menggunakan alat ichroma metode fluorescence immunoassay (FIA). Analisis statistik untuk menguji normalitas data menggunakan Shapiro wilk test, Independent t test dilakukan untuk mengetahui perbedaan rerata karakteristik antara kelompok obesitas dan non-obesitas, dan Spearman Rank digunakan untuk melihat korelasi antara HbA1c dengan kadar CRP.Hasil: Tidak ada korelasi antara kadar HbA1c dengan CRP pada penderita diabetes melitus tipe 2 dengan obesitas p = 0.420, r = 0,153 dan tanpa obesitas yaitu p= 0,182, r = 0,250.Simpulan: Kadar CRP yang terjadi pada pasien diabetes mellitus tipe 2 dimana inflamasi berjalan kronis tidak dipengaruhi oleh tingginya HbA1c baik pada kondisi obesitas maupun tidak obesitas.

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“…6 Chronic hyperglycaemia induces oxidative stress and chronic inflammatory state. 7 Chronic hyperglycaemia stimulates the release of various inflammatory cytokines such as IL-6 and TNF α and induces the secretion of acute phase reactants by the liver. 7 C-reactive protein is an acute-phase protein, act as an inflammatory marker produced and released by the liver under the stimulation of cytokines.…”

Section: Introductionmentioning

confidence: 99%

“…6 C-Reactive Protein measured by highly sensitive assays (hsCRP) is a very sensitive marker of inflammatory activity. 7 Netrin-1 is a laminin group protein encoded by the NTN1 gene which located on 17p13.1 chromosome. Netrin-1 is expressed by the central nervous system, endothelial cells of blood vessels, pancreas, liver, lymph, lungs, intestines and kidneys, which can act as an anti-inflammatory.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Glycated Haemoglobin with Netrin-1 and High Sensitive C-Reactive Proteinin Type 2 Diabetes Melitus Patients

2020

MLU

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Diabetes mellitus is a group of metabolic disease with the characteristic of hyperglycemia that occurs due to abnormal insulin secretion, insulin action or both. Low level inflammation plays a role in the mechanism of type 2 DM. Netrin-1 is a laminin protein group that has anti inflammatory properties. Netrin-1 is a new potential biomarker for diagnosing type 2 DM and its complications. High sensitive C-reactive protein is an acute phase protein produced by the liver in response to proinflammatory cytokines. Glycatedhaemoglobin test is a test recommended by the American Diabetes Association as a marker for diagnosis and predictor of the development of DM complications. The purpose of this study was to determine the correlation between glycatedhaemoglobin with netrin-1 and high sensitive C-reactive proteinin patients with type 2 DM. This cross sectional studyused type 2 DM patients as a sample. Fifty two type 2 DM patients participated in this study. The sample consisted of 21 samples of controlled type 2 DM and 31 samples of uncontrolled type 2 DM. The glycatedhaemoglobin was measured using immunoturbidimetry method, netrin-1 was measured using the ELISA method and hsCRP by immunoturbidimetry method . Data were analyzed statistically with the Mann Whitney and Spearman test.The results showed that netrin-1 in the uncontrolled type 2 DM group was higher than netrin-1 in the controlled type 2 DM group but there was not statistically significant (p> 0.05). High sensitive C-reactive protein in the uncontrolled type 2 DM group was higher than in the controlled type 2 DM group (p< 0.05). Glycatedhaemoglobin does not correlate with netrin-1 (p>0.05). Glycatedhaemoglobin was positively correlated with hsCRP with moderate correlation strength (p < 0.01, r = 0.418). Netrin-1 did not correlate with hsCRP (p > 0.05). It was concluded that netrin-1 and hsCRP were higher in uncontrolled DM. The higher glycatedhaemoglobin, the higher hsCRP too.

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Glycaemic control and C- reactive protein levels in type 2 diabetes mellitus -how well they co-relate?: a prospective study

Cited by 3 publications

References 13 publications

Study of association between C-reactive protein and albuminuria in type 2 diabetes mellitus

Study of association between C-reactive protein and albuminuria in type 2 diabetes mellitus

HUBUNGAN HbA1c DENGAN CRP PADA PENDERITA DIABETES MELITUS TIPE-2 DENGAN OBESITAS DAN TANPA OBESITAS

Correlation of Glycated Haemoglobin with Netrin-1 and High Sensitive C-Reactive Proteinin Type 2 Diabetes Melitus Patients

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