High-selenium yeast supplementation in free-living North American men: No effect on thyroid hormone metabolism or body composition

Effects of Zinc and Selenium Supplementation on Thyroid Function in Overweight and Obese Hypothyroid Female Patients: A Randomized Double-Blind Controlled Trial

“…In Hawkes and Keim's study [33], TT3 increased when Se was restricted (14 mg/d) and decreased when Se was increased (297 mg/d) in dietary foods during a 99-day intervention period. Hawkes et al [34], however, in a longer study (48 weeks), reported no difference in TT3 between high-and low-Se yeast-supplemented groups. In the present study, TT3 did not differ significantly between groups; thus, the observed decrease in TT3 concentrations in the SP group might be a transient effect of Se supplementation during the intervention period.…”

Frequent Consumption of Selenium-Enriched Chicken Meat by Adults Causes Weight Loss and Maintains Their Antioxidant Status

“…Many studies have assessed the efficacy of selenium supplements intake on antioxidant status and general health parameters of different populations, with pharmacological levels, ranging from 100 to 480 μg/day [21,24,25,28,32,33], while in the present trial the dose employed was of 36.4 μg/day (22 additional daily microgram compared with non-enriched chicken), and as novelty it was not consumed as a supplement, but it was provided with chicken breast. One of the aims of supplying a selenium supplement was to avoid the tachyphylactic process concerning antioxidant status after weight loss [10].…”

“…Indeed, almost all the research performed in relation to selenium intake has been carried out by administering high selenium concentrations as dietary supplements [21,24,25,28,32,33], while the effect of consumption of functional foods with a moderately higher content in selenium, within the recommended dietary allowance, has not yet been apparently assessed.…”

Effects of high selenium and fat supplementation on growth performance and thyroid hormones concentration of broilers

“…Although the effects of Se deficiency on thyroid hormone metabolism have been studied extensively in a number of animals [5,6] including chicken [7], very little is known about the influence of excess Se on thyroid hormone metabolism and selenoenzyme activities. In humans, Se supplementation led to variable results, depending on the Se status of the examined population group, extending from non to substantial changes in thyroid function [8][9][10][11][12]. Under this context, the form of Se (inorganic or organo-Se compounds) may also affect body Se reserves built and bioavailability [13,14].…”