High-risk human papillomavirus and cervical lesions among women living with HIV/AIDS in Brazilian Amazon, Brazil

Silva, Leila da; Miranda, Angélica Espinosa; Batalha, Rosieny Santos; Ferreira, Luíz Carlos Lima; Santos, Mayara Silva dos; Talhari, Sinésio

doi:10.1016/j.bjid.2015.07.001

Cited by 20 publications

(29 citation statements)

References 32 publications

(52 reference statements)

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“…This study found a prevalence of 28.4% of HR-HPV among women living with HIV/AIDS in Brazil. This result is lower than data described in previous studies in Rio de Janeiro (50.7%) 18 , Amazonas (61.6%) 19 and Rio Grande do Sul (68.0%) 20 . Some characteristics of these studies can explain the variety in the prevalence rates.…”

Section: Discussioncontrasting

confidence: 78%

“…A study in Cameroon (Africa) showed that severe and less severe lesions among WLHIV were prevalent at all ages and that, therefore, an age‐targeted screening among those women are of little utility . The abnormal cervical cytology was present in 8.9% of women, whereas the HPV prevalence was 28.4%, similar data were found in another sites . The performance of molecular biology screening can help to recognize the target population who needs to be attended more carefully, in low and middle development countries.…”

Section: Discussionmentioning

confidence: 83%

“…21 This result was different from another study conducted in South Brazil that found higher prevalence of HPV infection in WLHIV with 40 or more years old. 20 However a study in Sub-Saharan Africa also found higher prevalence of HPV in younger (18)(19)(20)(21)(22)(23)(24)(25) WLHIV, although the authors did not found a tendency of decreasing HPV prevalence with increasing age. 23 Generally among women, HPV prevalence decreases with age 24 but this is not necessarily the case for WLHIV.…”

Section: Discussionmentioning

confidence: 88%

“…26 The abnormal cervical cytology was present in 8.9% of women, whereas the HPV prevalence was 28.4%, similar data were found in another sites. 19,22 The performance of molecular biology screening can help to recognize the target population who needs to be attended more carefully, in low and middle development countries. The real benefits of DNA-HPV screening in HIV infected population need to be clarified.…”

Section: Discussionmentioning

confidence: 99%

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High‐risk papillomavirus infection among women living with human Immunodeficiency virus: Brazilian multicentric study

Miranda

Silveira

Travassos³

et al. 2017

Journal of Medical Virology

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Cervical cancer is an important health issue in Latin America. Although HPV infections can have spontaneous clearance, persistence of high-risk (HR) HPV is a risk factor for cervical cancer among women and it is even higher in HIV-infected women. To determine the prevalence of HR-HPV and risk factors among HIV-infected women attending reference services for HIV/AIDS in different regions of Brazil. Cross-sectional study conducted among HIV-infected women attended at referral care centers for HIV/AIDS in nine states of Brazil. Women from 18 to 49 years that accept to participate and were not pregnant at the time of the approach were recruited for the study. The HPV screening was realized using qPCR in closed system, in vitro Diagnostic, COBAS -HPV Roche. The cytology results were available by the Bethesda System. A total of 802(89.1%) from the selected women agreed to participate in the study. Median age was 39(Inter quartile range [IQR34-46]) years and median education was 9(IQR6-11) years. General prevalence of HR-HPV was 28.4%(228/802). HPV-16 prevalence rate was 8.1%(65/802), HPV-18 was 3.7%(30/802) and other types of HR-HPV were 23.6% (189/802). Risk factors for HR-HPV infection in the multivariate logistic regression analysis were: age ranging from 18 to 34 years (OR = 1.43[95%CI:1.18-1.75]), illicit drugs use (OR = 1.61[95%CI:1.10-2.42]) and abnormal cervical cytology (OR = 1.56[95%CI:1.34-1.81]). Results showed a prevalence rate of 28.4% of HR-HPV infection in women living with HIV in Brazil. These infections were significantly associated with having less than 35 years old, illicit drug use and abnormal cervical cytology.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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High‐risk papillomavirus infection among women living with human Immunodeficiency virus: Brazilian multicentric study

Miranda

Silveira

Travassos³

et al. 2017

Journal of Medical Virology

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“…Estudo realizado por Sopracordevole et al, (12) na Universidade da Califórnia, verificaram que o risco de neoplasia intraepitelial cervical é maior em pacientes com contagem de linfócitos T CD4 + inferior a 200 células/mm 3 . Da Silva et al, (13) ao estudarem 310 mulheres HIV positivo no Amazonas concluíram que aquelas que apresentaram lesões de alto grau (HSIL) e contagem de células TCD4 + <200 cels/mm³ (p<0,001) apresentaram maior risco à infecção pelo HPV.…”

Section: Methodsunclassified

Precursor lesions of cervical cancer in HIV-positive women and their relationship with CD4+ and viral load Gaffrée and Guinle University Hospital

Maia¹,

Furtado²,

Carvalho³

et al. 2017

Revista Brasileira De Análises Clínicas

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Lesões precursoras do câncer uterino em mulheres HIV-positivo e sua relação com linfócitos CD4 + e carga viral do Hospital Universitário Gaffrée e Guinle -UNIRIO Precursor lesions of cervical cancer in HIV-positive women and their relationship with CD4 + and viral load Artigo Original/Original Article Resumo Objetivo: Associar as alterações citológicas do colo uterino com a carga viral e a contagem de CD4 + das pacientes portadoras do vírus HIV. Métodos: O estudo realizado foi transversal e prospectivo, sendo 112 mulheres examinadas, e o exame citológico foi colhido no HUGG e corado pela técnica de Papanicolaou na SITEC/ INCA. A carga viral e contagem de CD4 + foram retiradas dos prontuários das pacientes. Resultados: A frequência das alterações citológicas foi de 15,2%, sendo 7,1% de LSIL, 4,5% de ASCUS e 3,6% de HSIL. Pacientes com CD4 + menor que 200 células ou sem adesão ao tratamento apresentaram maior frequência de alterações citológicas; pacientes com CD4 + maior que 500 células e carga viral indetectável apresentaram menor frequência de alterações citológicas. Conclusão: Esses resultados demonstraram que houve maior frequência de alterações citológicas nas mulheres com menor contagem de CD4 + ou sem adesão ao tratamento, demonstrando uma maior associação de alterações citológicas nas mulheres com doenças que provocam imunossupressão e reforçando a importância do rastreamento do câncer de colo uterino nas mulheres HIV positivo. Palavras-chaveNeoplasias do colo do útero; HIV; Citodiagnóstico 1 Mestre em infecção HIV/AIDS e hepatites

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Prevalence and correlates of cervical HPV infection in a clinic-based sample of HIV-positive Hispanic women

Ortiz

Tamayo

Scorsone

et al. 2017

Papillomavirus Research

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ObjectivesPuerto Rico (PR), is the fifth highest jurisdiction of the United States of America (US) with respect to HIV prevalence and the leading in cervical cancer incidence. This cross-sectional study describes the prevalence and correlates of cervical HPV infection among a clinic-based sample of 302 women living with HIV/AIDS in PR.MethodsData collection included questionnaires, blood and cervical samples. Multivariable logistic regression models were used to estimate the magnitude of association (adjusted Prevalence odds ratio [aPOR]) between HPV cervical infection and other covariates.ResultsMean age of participants was 40.3 years (± 10.3 SD). The prevalence of HPV infection was 50.3%; 41.1% for low-risk types and 29.5% for high-risk types. Having ≥ 10 lifetime sexual partners (aPOR = 2.10, 95% CI:1.02–4.29), an abnormal Pap (aPOR = 3.58, 95% CI:1.93–6.62), active genital warts (aPOR = 3.45, 95% CI:1.60–7.42), and CD4 counts ≤ 200 (aPOR = 4.24, 95% CI: 1.67–10.78) were positively associated with any cervical HPV infection. Similar results were observed for HR HPV infection.ConclusionsA high burden of HPV co-infection exists among women living with HIV/AIDS in this population. Given the high incidence of HIV in PR and the higher risk of cervical cancer among women living with HIV/AIDS, HPV vaccination should be promoted in this population.

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High-risk human papillomavirus and cervical lesions among women living with HIV/AIDS in Brazilian Amazon, Brazil

Abstract: In the present study high-risk human papillomavirus infection was frequent and it was associated to high-SIL. These results show the importance of gynecologic examinations in routine care and follow-up required by those who present with cervical lesions.

Cited by 20 publications

References 32 publications

High‐risk papillomavirus infection among women living with human Immunodeficiency virus: Brazilian multicentric study

High‐risk papillomavirus infection among women living with human Immunodeficiency virus: Brazilian multicentric study

Precursor lesions of cervical cancer in HIV-positive women and their relationship with CD4+ and viral load Gaffrée and Guinle University Hospital

Prevalence and correlates of cervical HPV infection in a clinic-based sample of HIV-positive Hispanic women

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