High-resolution melting analyses for genetic variants in ARID5B and IKZF1 with childhood acute lymphoblastic leukemia susceptibility loci in Taiwan

Lin, Chien Yu; Li, Meng Ju; Chang, Jui‐Hsing; Liu, Su Ching; Weng, Te‐Fu; Wu, Kou Juey; Yang, Shu; Huang, Fu; Lo, Wan Yu; Peng, Ching Tien

doi:10.1016/j.bcmd.2013.10.003

Cited by 35 publications

(33 citation statements)

References 30 publications

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“…However, due to the limited number of relevant studies among Asian populations included in this meta-analysis, the pooled results in Asian subgroup may have insufficient statistical power to detect a slight effect or have generated a fluctuated risk estimate. Besides, in Asian subgroup, the genotype distributions in the control population of Lin's study (Lin et al, 2014) was deviated from HWE. Because of the reasons of disequilibrium, the results of genetic association studies might be spurious (Trikalinos et al, 2006).…”

Section: Discussionmentioning

confidence: 82%

“…2 =17%). Sensitivity analyses indicated that no single study qualitatively affected the pooled ORs (including two studies (Healy et al, 2010;Lin et al, 2014) that deviated from HWE), suggesting that the results of our meta-analysis were highly stable. No publication bias was identified for SNP rs7089424 (Table 2 and Figure 4B).…”

Section: Meta-analysis About Snp Rs7089424mentioning

confidence: 94%

“…Among the included articles, two articles only reported allele contrasts (Orsi et al, 2012;Xu et al, 2012). For SNP rs7089424, nine articles including 11 studies (totally 4378 patients and 7928 controls) were included in the analyses (Papaemmanuil et al, 2009;Healy et al, 2010;Prasad et al, 2010;Vijayakrishnan et al, 2010;Pastorczak et al, 2011;Lautner-Csorba et al, 2012;Orsi et al, 2012;Gutierrez-Camino et al, 2013;Lin et al, 2014), but one article only provided allele contrast (Orsi et al, 2012). For studies only provided allele contrasts, the deviation of HWE for the genotype distribution in controls was not performed because of insufficient data.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…So subtype analyses of B-lineage ALL and B-hyperdiploid ALL were performed based on these articles. For SNP rs7089424, 5 articles including 6 studies provided the genotypes of B-lineage ALL cases and other subtype ALL cases (Papaemmanuil et al, 2009;Healy et al, 2010;Vijayakrishnan et al, 2010;Gutierrez-Camino et al, 2013;Lin et al, 2014). So we used these articles for subtype analyses.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

Zeng

Wang²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (15), 6211-6217 IntroductionAcute lymphoblastic leukemia (ALL), the most common malignancy in children (Linabery and Ross, 2008;Jiang et al., 2013), is a heterogeneous disease, with respect to its underlying cellular and molecular biology (Papaemmanuil et al., 2009), acquired genetic abnormalities, and social clinical responses to combination chemotherapy (Pui et al., 2004). The mechanisms involved in the etiology of childhood ALL remain obscure. It is hypothesized that both environmental and genetic factors contribute to the initiation of leukemogenesis (Greaves, 2006). Previous genome-wide association studies (GWAS) have implicated the associations of several single nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene with childhood ALL (Papaemmanuil et al., 2009;Trevino et al., 2009). Importantly, the ARID5B gene showed specificity for B lineage ALL and B-hyperdiploid subtype (Papaemmanuil et al., 2009;Trevino et al., 2009) ARID5B, the gene encoding the ARID5B protein, which located on chromosome 10q21.2, is one of the common susceptibility loci associated with childhood ALL risk (Papaemmanuil et al., 2009 Abstract Previous genome-wide association studies (GWAS) have implicated several single nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene with childhood acute lymphoblastic leukemia (ALL).However, replicated studies reported some inconsistent results in different populations. Using meta-analysis, we here aimed to clarify the nature of the genetic risks contributed by the two polymorphisms (rs10994982, rs7089424) for developing childhood ALL. Through searches of PubMed, EMBASE, and manually searching relevant references, a total of 14 articles with 16 independent studies were included. Odds ratios (ORs) with 95% confidence intervals (95%CI) were calculated to assess the associations. Both SNPs rs10994982 and rs7089424 showed significant associations with childhood ALL risk in all genetic models after Bonferroni correction. Furthermore, subtype analyses of B-lineage ALL provided strong evidence that SNP rs10994982 is highly associated with the risk of developing B-hyperdiploid ALL. These results indicate that SNPs rs10994982 and rs7089424 are indeed significantly associated with increased risk of childhood ALL.

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Section: Discussionmentioning

confidence: 82%

Section: Meta-analysis About Snp Rs7089424mentioning

confidence: 94%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

Zeng

Wang²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…[21,22] This method has been widely used in medical research applications, including detection of cancer-specific mutations [23,24]; moreover, it is also utilized to authenticate plant species and their processed products, as well as to accurately quantify adulterants in food products.…”

Section: Introductionmentioning

confidence: 99%

Application of barcode high-resolution melting for rapid authentication of the medicinal plant Psammosilene tunicoides

Song

Xiong

et al. 2016

Biotechnology & Biotechnological Equipment

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Psammosilene tunicoides is an important herb used in traditional Chinese medicine. It has been proved to benefit the stomach and treat rheumatism and gout. On the market, this herbal medicine is frequently adulterated by the related species Silene viscidula. Correct identification of P. tunicoides is important to ensure herbal quality, safety, authenticity and health for consumers. However, the identification of the P. tunicoides and S. viscidula species is complicated because of their morphological similarities. Therefore, a reliable method to authenticate these two medicinal plants is needed. In this study, the ITS2 barcode region coupled with high-resolution melting (Bar-HRM) was evaluated as a novel approach for differentiating P. tunicoides from its adulterant S. viscidula. Our findings showed that Bar-HRM not only detected the adulteration, but also quantified the most common admixture. Bar-HRM sensitivity in adulterant detection was assessed by analysing samples mixed with different proportions of S. viscidula and P. tunicoides control. The results are presented as a linear regression with R 2 D 0.9852, which implied the capability of the method to detect adulteration. This study is significant to verify the authenticity for better quality control of this herbal species.

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Childhood cancer incidence among specific Asian and Pacific Islander populations in the United States

Moore

Hubbard

Williams

et al. 2020

Intl Journal of Cancer

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Despite the vast genetic and environmental diversity in Asia, individuals of Asian and Pacific Islander (API) descent are often combined into a single group for epidemiologic analyses within the U.S. We used the Surveillance, Epidemiology and End Results (SEER) Detailed Asian/Pacific Islander Database to calculate incidence rates for discrete groups among children aged 0 to 19 years. Due to sample size constraints we pooled incidence among regional groups based on countries of origin: East Asians (Chinese, Japanese, Korean), Southeast (SE) Asians (Vietnamese, Laotian, Cambodian), Asian Indian/Pakistani, Oceanians (Guamanian, Samoan, Tongan) and Filipinos. Incidence rate ratios (IRR) and 95% confidence intervals (CI) were calculated comparing each API regional group to Non-Hispanic Whites (NHW) and East Asians. Finally, we calculated the correlation between incidence of cancer in specific API ethnicities in SEER and in originating countries in the Cancer Incidence in Five Continents. Incidence rates among API regional groups varied. Acute lymphoblastic leukemia (ALL) was lower in children of SE Asian descent (IRR 0.65, 95% CI 0.44, 0.96) compared to NHW. Acute myeloid leukemia (AML) was more common among children from Oceania compared to NHW (IRR 3.88, 95% CI 1.83, 8.22). East Asians had higher incidence rates than SE Asians but lower rates compared to children from Oceania. Correlation of some incidence rates between US-based API ethnicities and originating countries were similar. The variation observed in childhood cancer incidence patterns among API groups may indicate differences in underlying genetics and/or patterns of exposure.

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High-resolution melting analyses for genetic variants in ARID5B and IKZF1 with childhood acute lymphoblastic leukemia susceptibility loci in Taiwan

Cited by 35 publications

References 30 publications

Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

Application of barcode high-resolution melting for rapid authentication of the medicinal plant Psammosilene tunicoides

Childhood cancer incidence among specific Asian and Pacific Islander populations in the United States

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