High renal resistive index in hypertensive patients is also associated with serum homocysteine level

Keşkek, Şakir Özgür; Çinar, Yavuz Selim; Kırım, Sinan; Saler, Tayyibe

doi:10.1007/s10157-014-1050-6

Cited by 4 publications

(6 citation statements)

References 21 publications

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“…A positive correlation between RRI and insulin resistance has been shown previously [5,6]. Insulin resistance has been also shown in subjects with BTM [7].…”

Section: Introductionmentioning

confidence: 70%

“…HOMA-IR, homeostasis model assessment of insulin resistance; BTM, beta thalassemia minor; HDL, high-density lipoprotein; LDL, low-density lipoprotein. tients with hypertension [5]. Kawai et al [10] reported high values of RRI in a group of 143 hypertensive patients; similarly, Trovato et al [11] reported high RRI in 119 hypertensive individuals compared to 150 subjects with a normal blood pressure.…”

Section: Discussionmentioning

confidence: 95%

“…Besides, BTM is found to be associated with some cardiovascular risk factors such as insulin resistance and diabetes mellitus [7,8]. On the other hand, RRI is a good indicator of intrarenal hemodynamics and it has been also found to be associated with diabetes mellitus and insulin resistance [5,6,9].…”

Section: Discussionmentioning

confidence: 99%

“…High RRI have been demonstrated previously in patients with hypertension. In a study by Keşkek et al [5], 116 patients with hypertension were compared with 105 healthy subjects; the authors found higher RRI in pa- Values are presented as means ± SD. HOMA-IR, homeostasis model assessment of insulin resistance; BTM, beta thalassemia minor; HDL, high-density lipoprotein; LDL, low-density lipoprotein.…”

Section: Discussionmentioning

confidence: 99%

“…The RRI has been found to be associated with arteriosclerosis and tubulointerstitial disorders. Moreover, a significant correlation persists between high levels of RRI and cardiovascular diseases [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Better Renal Resistive Index Profile in Subjects with Beta Thalassemia Minor

2018

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Objective: Beta thalassaemia minor is a common genetic disorder without any characteristic symptoms except mild anemia. It is found to be associated with some cardiovascular risk factors such as insulin resistance and diabetes mellitus. The renal resistive index (RRI) is a measure of renal arterial resistance to blood flow. The aim of this study was to evaluate the RRI in subjects with beta thalassemia minor (BTM). Subjects and Methods: A total of 253 subjects were included in this cross-sectional study. The study group consisted of 148 subjects with BTM and the control group consisted of 105 healthy subjects. BTM was diagnosed by a complete blood count and hemoglobin electrophoresis. Blood pressure measurement and biochemical tests were performed. The RRI of all subjects was measured using renal Doppler ultrasonography. Results: Subjects with BTM had lower renal resistive indices compared to healthy subjects (0.58 ± 0.04 vs. 0.60 ± 0.06, p = 0.0016). Additionally, the RRI levels of subjects with BTM were correlated with systolic blood pressure (p = 0.017, r = 0.194). Conclusion: In this study, lower RRI were found in subjects with BTM. This may be associated with a decreased vascular resistance and blood viscosity in these subjects.

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“…A positive correlation between RRI and insulin resistance has been shown previously [5,6]. Insulin resistance has been also shown in subjects with BTM [7].…”

Section: Introductionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Better Renal Resistive Index Profile in Subjects with Beta Thalassemia Minor

2018

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Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review

et al. 2017

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Evidence on the causal link between homocysteine and hypertension from a meta‐analysis of 40 173 individuals implementing Mendelian randomization

Luo

et al. 2019

J of Clinical Hypertension

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Numerous researchers have investigated the associations among methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism, homocysteine (Hcy) concentration, and hypertension. However, the results are controversial. Thus, a meta‐analysis implementing Mendelian randomization approach was conducted to examine the hypothesis that elevated Hcy concentration plausibly contributes to increased risk of hypertension. Based on several inclusion and exclusion criteria, eligible studies were selected to explore the correlation between MTHFR C677T and hypertension risk, MTHFR C677T and Hcy concentration in hypertension, and Hcy concentration and hypertension, and they were evaluated by odds ratios (ORs), effect size (ES), and standard mean difference with their corresponding 95% confidence intervals (95% CIs), respectively. Moreover, Mendelian randomization was implemented to evaluate the relationship between Hcy and hypertension. Consequently, 14 378 cases and 25 795 controls were involved in this study and the results showed that MTHFR C677T led to an elevated risk of hypertension (for T vs C: OR = 1.27, 95% CI = 1.17‐1.37; for TT vs CC: OR = 1.53, 95% CI = 1.30‐1.79). Additionally, in hypertensive subjects, the pooled Hcy concentration in individuals of TT genotype was 7.74 μmol/L (95% CI: 5.25‐10.23) greater than that in individuals of CC genotype. Moreover, the pooled Hcy concentration in hypertensive was 0.69 μmol/L (95% CI: 0.50‐0.87) greater than that in controls. The estimated causal OR associated with hypertension was 1.32 for 5 μmol/L Hcy increment. Via MTHFR C677T polymorphism, the findings in the present study demonstrated that there exists evidence on causal link between Hcy concentration and the risk of hypertension.

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High renal resistive index in hypertensive patients is also associated with serum homocysteine level

Abstract: High renal resistive index in hypertensive patients is associated with homocysteine.

Cited by 4 publications

References 21 publications

Better Renal Resistive Index Profile in Subjects with Beta Thalassemia Minor

Better Renal Resistive Index Profile in Subjects with Beta Thalassemia Minor

Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review

Evidence on the causal link between homocysteine and hypertension from a meta‐analysis of 40 173 individuals implementing Mendelian randomization

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