Evidence on the causal link between homocysteine and hypertension from a meta‐analysis of 40 173 individuals implementing Mendelian randomization

Zhang

et al. 2020

Preprint

Background: This study aimed to investigate the relationship between H-type hypertension and retinal vessel abnormalities. Methods: Hypertensive patients were retrospectively enrolled in this study. According to plasma homocysteine (HCY), patients were divided into isolated hypertension and H-type hypertension groups. The diameter of retinal vessels and retinopathy were evaluated using retinal fundus photography. The differences of retinal vessel abnormalities between H-type hypertension and isolated hypertension were investigated by univariate and multivariate regression. Results: A total of 191 hypertensive patients were included, of which 86 were with isolated hypertension and 105 with H-type hypertension. The H-type hypertension group had a higher ratio of retinopathy(P=0.004) and higher degree of retinal arteriosclerosis (P=0.005) than the isolated hypertension group. CRAE (107.47±13.99mm v 113.49±11.72mm, P=0.002) and AVR (0.55±0.06 v 0.58±0.06, P=0.001) were smaller in H-type hypertension group than those in isolated hypertension group. Multivariate analysis showed that after adjusting for age, sex, course of hypertension and diabetes, H-type hypertension was an independent risk factor of retinopathy(OR, 2.259; 95%CI, 1.165—4.378; P=0.016), CRAE (B=-5.669; 95%CI, -9.452—-1.886; P=0.004), and AVR (B=-0.023; 95%CI,-0.039—-0.007; P=0.005). Conclusion: H-type hypertension is closely related to more retinal vessel abnormalities than isolated hypertension. Controlling H-type hypertension may reduce the risk of small vascular damage.

Section: Discussionsupporting

confidence: 67%

The association between retinal vessel abnormalities and H-type hypertension

Zhang

et al. 2020

Preprint

“…A meta-analysis had identi ed potentially relevant researches up to August 1, 2019. The conclusion was that hypertension was closely associated with HCY [9]. According to previous ndings, a high level of HCY did harm to systemic vascular endothelial cells [10,11].…”

Section: Discussionmentioning

confidence: 84%

The Association Between Retinal Vessel Abnormalities and H-type Hypertension

Yun

et al. 2020

Preprint

Introduction: This study aimed to investigate the relationship between H-type hypertension and retinal vessel abnormalities. Methods: Hypertensive patients were retrospectively enrolled in this study. According to serum homocysteine (HCY), patients were divided into isolated hypertension and H-type hypertension group. Retinal fundus photography was used to evaluate the diameter of retinal vessels and retinopathy. Univariate and multivariate regression were used to investigate difference of retinal vessel abnormalities between H-type hypertension and isolated hypertension patients. Results: A total of 191 hypertensive patients were included, of which 85 were isolated hypertension and 106 were H-type hypertension. H-type hypertension patients had a higher ratio of retinopathy(P=0.004) and higher degree of retinal arteriosclerosis (P=0.005). CRAE(P=0.002) and AVR(P=0.001) were smaller in H-type hypertension group. Multivariate analysis showed that after adjusting for age, sex, course of hypertension and diabetes, H-type hypertension were still risk factor of retinopathy(OR, 2.259; 95%CI, 1.165—4.378; P=0.016), CRAE (B=-5.669; 95%CI, -9.452—-1.886; P=0.004), and AVR(B=-0.023; 95%CI,-0.039—-0.007; P=0.005). Conclusion: H-type hypertension may aggravate retinal vessel abnormalities compared with isolated hypertension.

“…Previous studies found that HCY is another major risk factor for cerebrovascular disease in addition to hypertension. A meta-analysis also found that hypertension was closely associated with HCY, and there is a direct interaction between hypertension and HCY [ 14 ]. In our study, the median value of HCY in H-type hypertension group was 14.25 µmol/L (interquartile range, 12.23 to 18.37 µmol/L).…”

Section: Discussionmentioning

confidence: 99%

The association between retinal vessel abnormalities and H-type hypertension

et al. 2021

Background This study aimed to investigate the relationship between H-type hypertension and retinal vessel abnormalities. Methods Hypertensive patients were retrospectively enrolled in this study. According to plasma homocysteine (HCY), patients were divided into isolated hypertension and H-type hypertension groups. The diameter of retinal vessels and retinopathy were evaluated by retinal fundus photography. The differences of retinal vessel abnormalities between H-type hypertension and isolated hypertension were investigated by univariate and multivariate regression. Results A total of 191 hypertensive patients were included, of which 86 were with isolated hypertension and 105 with H-type hypertension. The H-type hypertension group had a higher ratio of retinopathy(P = 0.004) and higher degree of retinal arteriosclerosis (P = 0.005) than the isolated hypertension group. CRAE (107.47 ± 13.99µ m vs. 113.49 ± 11.72µ m, P = 0.002) and AVR (0.55 ± 0.06 vs. 0.58 ± 0.06, P = 0.001) were smaller in H-type hypertension group than those in isolated hypertension group. Multivariate analysis showed that after adjusting for age, sex, course of hypertension and diabetes, H-type hypertension was an independent risk factor of retinopathy (OR, 2.259; 95%CI, 1.165—4.378; P = 0.016), CRAE (β=-5.669; 95%CI, -9.452—-1.886; P = 0.004), and AVR (β=-0.023; 95%CI, -0.039—-0.007; P = 0.005). Conclusions H-type hypertension is closely related to more retinal vessel abnormalities than isolated hypertension. Controlling H-type hypertension may reduce the risk of small vascular damage.