Better Renal Resistive Index Profile in Subjects with Beta Thalassemia Minor

Basut, Fahrettin; Keşkek, Şakir Özgür; Gülek, Bozkurt

doi:10.1159/000489780

Cited by 3 publications

(5 citation statements)

References 13 publications

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“…This chronic anemia decreases arterial resistance with secondary hyperdynamic circulation and increased GFR [133]. Glomerular hyperfiltration accelerates mesangial sclerosis and tubular damage, which favors proteinuria, hypercalciuria, hyperuricosuria, and high excretion of beta-microglobin [133,134]. Thereby, ꞵ-thalassemia patients have elevated GFR with normal or reduced creatinine serum levels but with increased RRI from the early stages of the hematological disease [134].…”

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

“…Glomerular hyperfiltration accelerates mesangial sclerosis and tubular damage, which favors proteinuria, hypercalciuria, hyperuricosuria, and high excretion of beta-microglobin [133,134]. Thereby, ꞵ-thalassemia patients have elevated GFR with normal or reduced creatinine serum levels but with increased RRI from the early stages of the hematological disease [134]. In addition, RRI variation and delta RRI, parameters obtained during renal stress test, are useful tools for early diagnosis of subclinical renal dysfunction in ꞵ-thalassemia in order to improve the management of this disease [133].…”

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

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Current Insights into Renal Resistive Index Significance in Kidney and Cardiovascular Disease

Darabont¹,

Mihalcea²,

Vinereanu³

2023

Preprint

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Initially, renal resistive index (RRI) was investigated to improve diagnosis in kidney diseases, but failed to meet this goal. Recently many papers highlighted the prognostic significance of RRI in chronic kidney disease, in the estimation of revascularization success of renal artery stenoses or the evolution of the graft and recipients in renal transplantation. Moreover, RRI gained importance in prediction of acute kidney injury in critically ill patients. Along with RRI study in renal pathology have been revealed correlations of this index with parameters of systemic circulation. The theoretical and experimental premises of this connection were reconsidered, and studies for analyzing the link between RRI and arterial stiffness, central and peripheral pressure or left ventricular flow were conducted with this purpose. A high amount of data is currently indicating that RRI is influenced more by pulse pressure and vascular compliance than by renal vascular resistance – assuming that RRI reflects the complex interplay between systemic circulation and renal microcirculation and should be considered as a marker of systemic cardiovascular risk beyond its prognostic relevance for kidney disease. In this review we will go through clinical research that revealed the implications of RRI in renal and cardiovascular disease.

show abstract

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

Current Insights into Renal Resistive Index Significance in Kidney and Cardiovascular Disease

Darabont¹,

Mihalcea²,

Vinereanu³

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…This chronic anemia decreases arterial resistance with secondary hyperdynamic circulation and increased GFR [130]. Glomerular hyperfiltration accelerates mesangial sclerosis and tubular damage, which favors proteinuria, hypercalciuria, hyperuricosuria, and the elevated excretion of beta-microglobin [130,131]. Thereby, B-thalassemia patients have elevated GFR with normal or reduced creatinine serum levels but an increased RRI from the early stages of the hematological disease [131].…”

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

“…Glomerular hyperfiltration accelerates mesangial sclerosis and tubular damage, which favors proteinuria, hypercalciuria, hyperuricosuria, and the elevated excretion of beta-microglobin [130,131]. Thereby, B-thalassemia patients have elevated GFR with normal or reduced creatinine serum levels but an increased RRI from the early stages of the hematological disease [131]. In addition, RRI variation and delta RRI, parameters obtained during renal stress tests, are useful tools for the early diagnosis of subclinical renal dysfunction in B-thalassemia and may improve the management of this disease [130].…”

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease

2023

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Initially, the renal resistive index (RRI) was investigated with the aim of improving diagnosis in kidney diseases, but this goal was not met. Recently, many papers have highlighted the prognostic significance of the RRI in chronic kidney disease: specifically, in estimating the revascularization success of renal artery stenoses or the evolution of the graft and the recipients in renal transplantation. Moreover, the RRI has become significant in the prediction of acute kidney injury in critically ill patients. Studies in renal pathology have revealed correlations of this index with parameters of systemic circulation. The theoretical and experimental premises of this connection were then reconsidered, and studies analyzing the link between RRI and arterial stiffness, central and peripheral pressure, and left ventricular flow were conducted with this purpose. Many data currently indicate that RRI is influenced more by pulse pressure and vascular compliance than by renal vascular resistance—assuming that RRI reflects the complex interplay between systemic circulation and renal microcirculation and should be considered a marker of systemic cardiovascular risk beyond its prognostic relevance for kidney disease. In this review, we overview the clinical research that reveals the implications of RRI in renal and cardiovascular disease.

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“…Beta thalassemias are divided into 3 groups according to the clinical and laboratory findings, which are beta thalassemia minor (BTm), beta thalassemia intermedia (BTI), and beta thalassemia major (BTM). While BTM and BTI patients are usually symptomatic with frequent blood transfusion requirements, individuals with BTm occasionally have a mild asymptomatic microcytic anemia, which is usually incidentally encountered [3-5].…”

Section: Introductionmentioning

confidence: 99%

Beta Thalassemia Minor: Patients Are Not Tired but Depressed and Anxious

et al. 2020

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Objective: We aimed to investigate whether the severity of fatigue and the incidences of depression and anxiety of patients with beta thalassemia minor (BTm) are different from healthy individuals using the Fatigue Severity Scale (FSS) and Hospital Anxiety and Depression Scale (HADS). Subjects and Methods: BTm patients who were followed at the University of Health Sciences Istanbul Training and Research Hospital Hematology Clinic between 2016 and 2017 and who had normal biochemical parameters, thyroid function tests and C-reactive protein levels, and did not use any medications, consume alcohol or tobacco, have any chronic diseases or sleep disturbances were included in the study. Healthy control subjects who were matched with age, sex, marital status, educational status, and body mass index (BMI) were also included for comparison. Results: Thirty-nine BTm patients and 25 healthy controls were included in the study. The BTm and the control groups were comparable in terms of gender, age, BMI, educational status and marital status (p = 0.368, 0.755, 0.851, 0.785, and 0.709, respectively). FSS score was ≥4 in 23 (59.0%) BTm subjects and in 15 (60%) control subjects (p = 1.0). HADS anxiety score was ≥10 in 20 (51.3%) BTm subjects and in 5 (20.0%) control subjects (p = 0.018), and HADS depression score was ≥7 in 20 (51.3%) BTm subjects and in 6 (24.0%) healthy control subjects (p = 0.039).There was no correlation of hemoglobin with FSS score (p = 0.526, r = –0.105), HADS anxiety score (p = 0.703, r = –0.063), or HADS depression score (p = 0.718, r = –0.06) in the BTm group. Conclusion: We found that both depression and anxiety were higher in BTm patients than in healthy individuals, but this difference was not feasible for fatigue.

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Better Renal Resistive Index Profile in Subjects with Beta Thalassemia Minor

Cited by 3 publications

References 13 publications

Current Insights into Renal Resistive Index Significance in Kidney and Cardiovascular Disease

Current Insights into Renal Resistive Index Significance in Kidney and Cardiovascular Disease

Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease

Beta Thalassemia Minor: Patients Are Not Tired but Depressed and Anxious

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