High prevalence of isolated sperm DNA damage in infertile men with advanced paternal age

Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for male fertility evaluation. While its detrimental implications on sperm function were extensively investigated, little is known about the actual indications for performing SDF analysis. This review delivers practice based recommendations on commonly encountered scenarios in the clinic. An illustrative description of the different SDF measurement techniques is presented. SDF testing is recommended in patients with clinical varicocele and borderline to normal semen parameters as it can better select varicocelectomy candidates. High SDF is also linked with recurrent spontaneous abortion (RSA) and can influence outcomes of different assisted reproductive techniques. Several studies have shown some benefit in using testicular sperm rather than ejaculated sperm in men with high SDF, oligozoospermia or recurrent in vitro fertilization (IVF) failure. Infertile men with evidence of exposure to pollutants can benefit from sperm DNA testing as it can help reinforce the importance of lifestyle modification (e.g., cessation of cigarette smoking, antioxidant therapy), predict fertility and monitor the patient’s response to intervention.

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“…Age is a non-modifiable example (18,121). Advancing male age has been associated with increased frequency of sperm DNA defects (86-88).…”

Section: Indications For Sdf Testingmentioning

confidence: 99%

Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

Agarwal¹,

Majzoub²,

Esteves³

et al. 2016

Transl. Androl. Urol.

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318

415

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“…Age is one of the cofounding factors that contribute an important role in determining the status of DNA damage in human as aging has been proven scientifically as one of the factor that could contribute to higher sperm DNA damage in men (Das et al, 2013;Pharm et al, 2014). In prospective study involving human subject, age factor cannot be manipulated.…”

Section: Journal Of Agricultural Sciencementioning

confidence: 99%

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Jaafar¹,

Osman²,

Kumar³

et al. 2017

JAS

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There is no solid conclusion on the conventional sperm parameters in association with alcohol consumption, evaluation of sperm DNA integrity thus become a more reliable parameter. Hereby, this literature search was performed to summarize alcohol consumption on the sperm DNA integrity. A computerized database search was done through MEDLINE via Ovid (since 1946 until August 2017) and Cochrane was used. The following set of keywords: 'alcohol consumption OR alcohol intake OR alcohol diet OR drinking alcohol OR ethanol diet' AND 'sperm DNA OR sperm chromatin OR sperm genome OR sperm histone OR sperm protamine' were utilised. 24 articles were retrieved where only five studies conform to the inclusion criteria All studies demonstrated a negative effect of alcohol consumption on sperm DNA integrity, regardless of various range of alcohol doses and duration of alcohol consumption. Out of five studies reviewed, four studies were using a different approach to measure the sperm DNA damage. Hereby, this review identified a need to use a single approach of DNA damage test by having various method of alcohol administration and/or vice versa so that the extension of sperm DNA damage to alcohol consumption will have a better conclusion. On the same note, a few studies have reported the reversibility on conventional semen parameters, none has been done on the sperm DNA damage upon alcohol withdrawal. Therefore, the role of alcohol withdrawal on the reversibility of sperm DNA damage needs to be as well investigated further.

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“…Male fertility may decline as a consequence of falling testosterone levels, but overall men are capable of conceiving children without taking recourse to ART, well into their 90s. However, as men age, the quality of their gametes deteriorates (Singh et al 2003, Schmid et al 2007, Das et al 2013. As a result, the spermatozoa of ageing males contain much more DNA damage than their younger counterparts.…”

Section: Age and Reproduction: The Male Perspectivementioning

confidence: 99%

Age, the environment and our reproductive future: bonking baby boomers and the future of sex

Aitken

2014

Reproduction

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There has never been a greater need for scientists trained in reproductive science. Most developed countries are witnessing unprecedented rates of recourse to assisted conception sitting cheek-by-jowl with high rates of induced abortion. This article addresses these two incongruous faces of reproductive healthcare. Every year at least 44 million abortions are performed worldwide, many under unsafe and insanitary conditions that carry a significant risk to the lives of women deprived of safe, effective methods for controlling their fertility. Although birth control is a complex issue involving myriad social and political factors, the technical vacuum in this area is significant. Through no fault of the family planning authorities, there have been no radically new methods of fertility control since the oral contraceptive pill was introduced in 1960 and even this contribution to planned parenthood has its roots in the biochemistry of the 1920s and 1930s. Moreover, the pharmaceutical industry has, by and large, turned its back on fundamental research activities in this area. At present, our major investment in reproductive healthcare involves treating ever-increasing numbers of couples with assisted reproductive technologies (ART). However, these treatments are often delivered without critically considering the underlying causes of this condition or seriously contemplating the long-term consequences of the current enthusiasm for such therapy. Significantly, the clinical factors underpinning the commitment of couples to ART include advanced maternal age and a variety of lifestyle factors, such as smoking and obesity, which are known to compromise the developmental potential of the oocyte and DNA integrity in spermatozoa.

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High prevalence of isolated sperm DNA damage in infertile men with advanced paternal age

Cited by 86 publications

References 42 publications

Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Age, the environment and our reproductive future: bonking baby boomers and the future of sex

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