2014
DOI: 10.1530/rep-13-0399
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Abstract: There has never been a greater need for scientists trained in reproductive science. Most developed countries are witnessing unprecedented rates of recourse to assisted conception sitting cheek-by-jowl with high rates of induced abortion. This article addresses these two incongruous faces of reproductive healthcare. Every year at least 44 million abortions are performed worldwide, many under unsafe and insanitary conditions that carry a significant risk to the lives of women deprived of safe, effective methods … Show more

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Cited by 36 publications
(21 citation statements)
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“…Equally important, we examined the same parameters in indirectly exposed F3 males in order to determine if a hyper-inflammatory testicular phenotype could be transmitted across multiple generations. Since altered macrophage numbers have specifically been shown to be associated with poor testicular health (reviewed by [44]), we used immunolocalization of F4/80 to examine the number of macrophages present in the testes of control, F1 and F3 males. As shown in Figure 9A , under non-stimulatory conditions, testicular immune cells are rare in control males and limited to the interstitial space containing the leydig cells.…”
Section: Resultsmentioning
confidence: 99%
“…Equally important, we examined the same parameters in indirectly exposed F3 males in order to determine if a hyper-inflammatory testicular phenotype could be transmitted across multiple generations. Since altered macrophage numbers have specifically been shown to be associated with poor testicular health (reviewed by [44]), we used immunolocalization of F4/80 to examine the number of macrophages present in the testes of control, F1 and F3 males. As shown in Figure 9A , under non-stimulatory conditions, testicular immune cells are rare in control males and limited to the interstitial space containing the leydig cells.…”
Section: Resultsmentioning
confidence: 99%
“…Several of these comorbidities including diabetes have been independently associated with infertility (Calderon et al., ; Eisenberg, Li, Behr, Pera, & Cullen, ; Eisenberg, Li, Cullen, & Baker, ; Tavares et al., ). These observations have lead some researchers to believe that the inconsistencies among previous studies on obesity and sperm parameters may be due to the differential distribution of age, comorbidities and lifestyle factors among study populations (Aitken, ; Chambers & Richard, ; McPherson & Lane, ; Tsao et al., ; Zitzmann et al., ).…”
Section: Introductionmentioning
confidence: 99%
“…A study conducted with albino rats has shown that nicotine decreases levels of testosterone in both low‐ and high‐dose groups, whereas FSH levels decrease and LH levels increase only in the high‐dose (1.0 mg/kg) group ( p < 0.05) (Oyeyipo, Raji, & Bolarinwa, ). Decrease in testosterone levels may cause a deterioration of malefactor fertility (Aitken, ). Many studies have reported various genotoxic effects caused by nicotine not only in human spermatozoa (Ginzkey et al, ).…”
Section: Components Of Cigarette Smokementioning
confidence: 99%
“…Cadmium concentration has been found to be twice as much in smokers than in nonsmokers both in the fertile and infertile groups (Kumosani, Elshal, Al‐Jonaid, & Abduljabar, ). As a potent inhibitor of 8‐oxoguanine DNA glycosylase (OGG1), a significant DNA base excision repair enzyme, Cd exposure also causes an increase in oxidised base adducts in the sperm DNA (Aitken, ).…”
Section: Components Of Cigarette Smokementioning
confidence: 99%