High prevalence of HPV59 in cytologically abnormal cervical samples

Ye, Fei; Chan, Ngan Yin; Feng, Tao; Wu, Josephine W.; Jiang, Shiquang; Sperling, Rhoda; Zhang, David Y.

doi:10.1016/j.yexmp.2015.09.008

Cited by 3 publications

(2 citation statements)

References 20 publications

(16 reference statements)

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“…3a). This HPV genotype has also been observed in the top five HPV genotypes detected in different regions of the world, as reported, for example, in Ghana [47], China [48][49][50], and Switzerland [51].…”

Section: Discussionsupporting

confidence: 72%

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

et al. 2020

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Background Human papillomavirus infection is an important factor associated with cervical cancer (CC) development. The prevalence and genotype distribution vary greatly worldwide. Examining local epidemiological data constitutes an important step towards the development of vaccines to prevent CC. In this work, we studied the prevalence of HPV genotypes in women from Western Mexico with the COBAS 4800 and/or Linear Array Genotyping Test (LA). Methods The samples analysed in this study represent a population from Western Mexico, which includes six different states. Our approach was first to test for HPV in cervical samples from women who attended their health clinic for routine gynaecological studies (open-population, n = 3000) by utilizing COBAS 4800. Afterwards, 300 of the HPV-positive samples were randomly selected to be genotyped with LA; finally, we genotyped samples from women with cervical intraepithelial neoplasia grade 1 (CIN 1, n = 71) and CC (n = 96) with LA. Sociodemographic data of the diverse groups were also compared. Results The overall HPV prevalence among the open-population of women as determined by COBAS 4800 was 12.1% (n = 364/3000). Among the HPV-positive samples, single infections (SI) with HPV16 were detected in 12.4% (n = 45/364), SI with HPV18 were detected in 1.4%, and infection with at least one of the genotypes included in the high-risk HPV pool was detected in 74.5% of the cases. LA analysis of the samples showed that in addition to HPV genotypes 16 and 18, there was a high prevalence of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico. With respect to the sociodemographic data, we found statistically significant differences in the number of pregnancies, the use of hormonal contraceptives and tobacco intake. Conclusions Our data indicate that there is a high prevalence of HPV genotypes which are not covered by the vaccines currently available in Mexico; therefore, it is necessary to include HPVs 59, 66, 51, 39 and 56 in the design of future vaccines to reduce the risk of CC development. It is also essential to emphasize that the use of hormonal contraceptives and tobacco smoking are risk factors for CC development in addition to the presence of HPV.

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Section: Discussionsupporting

confidence: 72%

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

et al. 2020

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“…In a study of Southeast Asian women, only one patient tested positive for HPV 16, and the most common hrHPV genotypes were HPV 51, 52, 56, and 59 . At Mount Sinai Hospital, New York, HPV 59, 16 and 51 were the most common hrHPV types in women with abnormal cervical cytology . Recognition and understanding of regional variation are important to ensure appropriate molecular detection.…”

Section: Introductionmentioning

confidence: 99%

The ATHENA HPV study underrepresents “other” high‐risk HPV genotypes when compared with a diverse New York City population

et al. 2017

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Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis

Zhao,

Zhou,

Zhang

et al. 2023

PeerJ

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Objectives We aimed to estimate the genotype distribution of persistent human papillomavirus (HPV) infection in females worldwide, and provided a scientific basis for the prevention strategies of cervical cancer (CC) and the development of HPV vaccines. Methods Both English and Chinese databases were researched from the inception to July 2023. The pooled persistent HPV infection prevalence was calculated using a random effects model. The subgroup analysis was performed to explore the heterogeneity. Publication bias was evaluated using funnel plot, Egger’s and Begg’s test. Results Twenty-eight studies with 27,335 participants were included. The pooled prevalence of persistent HPV infection was 29.37% (95% CI [24.05%∼35.31%]), and the genotypes with the persistent infection prevalence were HPV16 (35.01%), HPV52 (28.19%), HPV58 (27.06%), HPV18 (25.99%), HPV33 (24.37%), HPV31 (23.35%), HPV59 (21.87%), HPV39 (19.54%), HPV68 (16.61%) and HPV45 (15.05%). The prevalence of multiple and single HPV persistent infection were 48.66% and 36.71%, respectively; the prevalence of persistent HPV infection in different age groups (<30, 30∼39, 40∼49, >50) were 29.83%, 28.39%, 22.24% and 30.22%, respectively. The follow-up time was significantly associated with heterogeneity by subgroup analysis (P < 0.05), and the prevalence of persistent infection decreased with longer follow-up time. Conclusions Multiple infections were more likely to occur persistent HPV infection than single infection. In addition to HPV vaccination, we should emphasize the follow-up management for women under 30 and over 50 years old, those with high-risk HPV infection (HPV59, 39, 68) and multiple infections.

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High prevalence of HPV59 in cytologically abnormal cervical samples

Cited by 3 publications

References 20 publications

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

The ATHENA HPV study underrepresents “other” high‐risk HPV genotypes when compared with a diverse New York City population

Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis

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