The <scp>ATHENA HPV</scp> study underrepresents “other” high‐risk <scp>HPV</scp> genotypes when compared with a diverse New York City population

Rivera, Gloria Ramos; Khader, Samer; Lajara, Sigfred; Schlesinger, Kathie; Goldstein, D. Yitzchak; Naeem, Rizwan; Suhrland, Mark J.; Fox, Amy

doi:10.1111/cyt.12440

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…In our study–which included samples from patients with normal cytology, both low and high grade lesions, and cervical cancer–we found that 79.2% of the patients present an infection with at least one HPV genotype, a frequency slightly higher than reported by other authors both nationally and globally, in studies including all referred lesion groups (68.4% by [21], 67.7% by [22], 67.1% by [23], 64.5% by [24], 66.7% by [25] in South Africa, and 59.4% by [26] in Croatia to name a few), and lower than documented by the IARC (who report that the percentage of cases of cervical cancer potentially attributed to HPV infection worldwide is 86.9%), although this fraction varies widely according to the geographic area and its socio-economic level [27].…”

Section: Discussionmentioning

confidence: 55%

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

et al. 2019

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Human papillomavirus has been identified as a main etiological agent in the development of cervical cancer. HPV 16 and 18 have been reported the most widely prevalent genotypes worldwide. We conducted a study analyzing the prevalence of high and low risk human papillomavirus viral types in the Mexican state of Aguascalientes and neighboring cities in the states of Jalisco and Zacatecas in central Mexico. Specific viral genotype was determined by a PCR and hybridization-based detection test. The presence of 37 high- and low-risk HPV genotypes was evaluated in 883 female participants. Of these, 350 presented low-grade squamous intraepithelial lesions (LGSIL), 176 presented high-grade squamous intraepithelial lesions (HGSIL), 107 suffered from cervical cancer and 250 women with negative cytological report for intraepithelial lesion or malignancy (NILM). HPV 51 was the most prevalent genotype, followed by HPV 16: overall prevalence of HPV 51, including single infections and co-infections was 31.2% in women with LGSIL, whereas prevalence of HPV 16 was 25.1%. Among women with HGSIL, HPV 51 prevalence was 47.2% and HPV 16 was 30.1%. Prevalence of HPV 51 in women with cervical cancer was 49.5% and type 16 was 33.6%. Between single and co-infections, most co-infections were not associated with later stages of the disease, except 51/16 and some others. HPV 51 showed a significant correlation with the progression of the disease (OR = 10.81 for LGSIL, 19.38 for HGSIL and 22.95 for ICC), and when analyzing all other genotypes, five different groups depending on their correlation with all lesion grades were determined. According to our findings, HPV genotype 51 has a higher prevalence than HPV 16 and 18 in the Mexican state of Aguascalientes and neighboring cities in the states of Jalisco and Zacatecas in Central Mexico.

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Section: Discussionmentioning

confidence: 55%

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

et al. 2019

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“…Our results also showed a higher prevalence of OHR HPV (69.0%) in the LROH population compared with HPV16 (10.0%) and HPV18 (5.0%). Ramos Rivera et al found OHR HPV were most commonly present in all groups and to be associated with the majority of HSILs in their study population.…”

Section: Discussionmentioning

confidence: 64%

Low‐grade squamous intraepithelial lesion, cannot rule out high‐grade lesion: Diagnosis, histological outcomes and human papillomavirus results

et al. 2018

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Investigating How Geography, Citizenship, and Insurance Influence HPV Vaccination

2019

AMA Journal of Ethics

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Research on the human papillomavirus (HPV) suggests a possible relation between HPV type and geography. It also demonstrates that insurance status affects HPV vaccine uptake, which currently provides protection against 9 of the high-risk HPV types known to cause HPVrelated cancers. This article reviews this literature with a focus on health justice in HPV vaccination programs. It also describes University of Illinois Health System research with members of Chicago communities to determine the prevalence of HPV, the distribution of HPV types, and strategies for better serving this population. Possible Influence of Geography on HPV Genotype Several studies have noted a high frequency of atypical high-risk HPV genotypes. Researchers in Michoacán, Mexico, noticed that there was a high frequency of "unusual virus genotypes" when they introduced a different type of testing into their methodology. 1 Specifically, it was found that HPV59 was most prevalent, along with other types (51, 45, 31, 58, 35, 39, 52, and 67) and "that HPV16 was only found in 3 coinfections and HPV18 was not found at all." Similarly, high rates of other high-risk HPV (ohrHPV) genotypes were found in patients in the Montefiore Medical Center, the Bronx, New York, which serves a racially diverse population. 2 Another study on the Midwestern population serviced by the Mayo Clinic in Rochester, Minnesota, also reported ohrHPV genotypes in its dominant diagnoses. 3

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The ATHENA HPV study underrepresents “other” high‐risk HPV genotypes when compared with a diverse New York City population

Abstract: Further evaluation is needed to determine if this pool of other hrHPV includes individual genotypes that in our population carry a higher risk of persistence and progression to cancer.

Cited by 5 publications

References 12 publications

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

Low‐grade squamous intraepithelial lesion, cannot rule out high‐grade lesion: Diagnosis, histological outcomes and human papillomavirus results

Investigating How Geography, Citizenship, and Insurance Influence HPV Vaccination

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