High prevalence of co-infection between human papillomavirus (HPV) 51 and 52 in Mexican population

Gallegos-Bolaños, Jazbet; Rivera-Domínguez, Jessica Alejandra; Presno-Bernal, José Miguel; Cervantes‐Villagrana, Rodolfo Daniel

doi:10.1186/s12885-017-3519-7

Cited by 29 publications

(31 citation statements)

References 37 publications

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“…In respect to the individual prevalence of each genotype according to lesion grade, we observed a differential behavior, even within high-risk genotypes which are shown to increase as the lesion progresses; this is most relevant to HPV 16 genotype, which has been reported to increase its presence in direct relation to the lesion grade, even in a meta-analysis of 30,165 women with HPV infection [46], but different from our results which show that HPV 16 prevalence peaks at a high-grade lesion but then decreases when the lesion progresses to cancer. In the same way we found that a HPV 16–51 concomitant infection follows the same pattern, although we consider that this observation origins from an elevated prevalence of HPV 51 observed in our study, and which is corroborated by other authors like Gallegos-Bolaños et al, who report an elevated prevalence of co-infection between HPV 51 and 52 in the Mexican population [39]. Elsewhere, high prevalence of HPV 51 in high-grade lesions and developing cervical cancer have been found in co-infection with other common high-risk genotypes such as 16, 18 or 33, most likely due to the high prevalence of the aforementioned genotypes in their respective populations [47–49].…”

Section: Discussionsupporting

confidence: 93%

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Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

et al. 2019

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Human papillomavirus has been identified as a main etiological agent in the development of cervical cancer. HPV 16 and 18 have been reported the most widely prevalent genotypes worldwide. We conducted a study analyzing the prevalence of high and low risk human papillomavirus viral types in the Mexican state of Aguascalientes and neighboring cities in the states of Jalisco and Zacatecas in central Mexico. Specific viral genotype was determined by a PCR and hybridization-based detection test. The presence of 37 high- and low-risk HPV genotypes was evaluated in 883 female participants. Of these, 350 presented low-grade squamous intraepithelial lesions (LGSIL), 176 presented high-grade squamous intraepithelial lesions (HGSIL), 107 suffered from cervical cancer and 250 women with negative cytological report for intraepithelial lesion or malignancy (NILM). HPV 51 was the most prevalent genotype, followed by HPV 16: overall prevalence of HPV 51, including single infections and co-infections was 31.2% in women with LGSIL, whereas prevalence of HPV 16 was 25.1%. Among women with HGSIL, HPV 51 prevalence was 47.2% and HPV 16 was 30.1%. Prevalence of HPV 51 in women with cervical cancer was 49.5% and type 16 was 33.6%. Between single and co-infections, most co-infections were not associated with later stages of the disease, except 51/16 and some others. HPV 51 showed a significant correlation with the progression of the disease (OR = 10.81 for LGSIL, 19.38 for HGSIL and 22.95 for ICC), and when analyzing all other genotypes, five different groups depending on their correlation with all lesion grades were determined. According to our findings, HPV genotype 51 has a higher prevalence than HPV 16 and 18 in the Mexican state of Aguascalientes and neighboring cities in the states of Jalisco and Zacatecas in Central Mexico.

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Section: Discussionsupporting

confidence: 93%

“…Also, Gallegos-Bolaños et al. found in 1,163 women and 166 men that the most common infection was caused by HPV 51 (42%), then 52 (38%) and 16 (37%) [39], similar to our results. Similarly, Gultekin et al, in a study including a million Turkish women, reported that the most frequent HPV genotype detected was 16, followed by 51 and 31 [40].…”

Section: Discussionsupporting

confidence: 92%

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

et al. 2019

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“…HPV52 and 51 were also frequently found in this study; however, they were mostly detected as coinfections. Both genotypes have been commonly reported as single infections and also as coinfections; the presence of HPV51-52 and coinfections of three genotypes, such as HPV16-51-52, are frequently detected in coinfections [57,58].…”

Section: Discussionmentioning

confidence: 99%

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

et al. 2020

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Background Human papillomavirus infection is an important factor associated with cervical cancer (CC) development. The prevalence and genotype distribution vary greatly worldwide. Examining local epidemiological data constitutes an important step towards the development of vaccines to prevent CC. In this work, we studied the prevalence of HPV genotypes in women from Western Mexico with the COBAS 4800 and/or Linear Array Genotyping Test (LA). Methods The samples analysed in this study represent a population from Western Mexico, which includes six different states. Our approach was first to test for HPV in cervical samples from women who attended their health clinic for routine gynaecological studies (open-population, n = 3000) by utilizing COBAS 4800. Afterwards, 300 of the HPV-positive samples were randomly selected to be genotyped with LA; finally, we genotyped samples from women with cervical intraepithelial neoplasia grade 1 (CIN 1, n = 71) and CC (n = 96) with LA. Sociodemographic data of the diverse groups were also compared. Results The overall HPV prevalence among the open-population of women as determined by COBAS 4800 was 12.1% (n = 364/3000). Among the HPV-positive samples, single infections (SI) with HPV16 were detected in 12.4% (n = 45/364), SI with HPV18 were detected in 1.4%, and infection with at least one of the genotypes included in the high-risk HPV pool was detected in 74.5% of the cases. LA analysis of the samples showed that in addition to HPV genotypes 16 and 18, there was a high prevalence of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico. With respect to the sociodemographic data, we found statistically significant differences in the number of pregnancies, the use of hormonal contraceptives and tobacco intake. Conclusions Our data indicate that there is a high prevalence of HPV genotypes which are not covered by the vaccines currently available in Mexico; therefore, it is necessary to include HPVs 59, 66, 51, 39 and 56 in the design of future vaccines to reduce the risk of CC development. It is also essential to emphasize that the use of hormonal contraceptives and tobacco smoking are risk factors for CC development in addition to the presence of HPV.

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“…HPV 16 and 18 co-infections were detected in 25 (41.7%) of the cases. However, co-infection up to 76% has been reported [25]. The prevalence and pattern of co-infection differ depending on the geographic area of study as well.…”

Section: Discussionmentioning

confidence: 99%

A fluorometric hybridization assay for detecting and genotyping high-risk human papillomavirus 16 and 18 in archival tissues of cervical specimens

et al. 2019

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Early diagnosis and genotyping of high-risk human papillomavirus (HR-HPV) in cervical tissue specimens is significant for cervical cancer prevention. A sensitive microplate fluorometric hybridization assay (MFHA) was designed for the detection of HPV DNA 16 and 18 in cervical tissue. Following optimization and validation of the method, 60 formalin-fixed and paraffinembedded cervical samples representing different cervical intraepithelial neoplasia grades of HPV-associated lesions were tested to determine the sensitivity and specificity of the assay. Using consensus GP5+/6+ biotin-labeled primers to amplify a conserved region within the L1 gene, the amplicons were added to the microplate wells coated with specific probes for the hybridization of HPV 16 and 18 individually. Final detection was performed with streptavidin-AlexaFluor488 conjugated. The results were then compared with type-specific nested polymerase chain reaction (PCR) and colorimetric microplate assay. While the agreement between the results obtained by the type-specific nested PCR and fluorometric assay for the detection of both HR-HPV types was 100%, this agreement for the detection of HPV type 16 and 18 using microplate colorimetric assay was 94.2% and 85% respectively. Overall, the results of the fluorometric and colorimetric assays are promising for detecting both HR-HPV types in a large number of cervical tissue samples with the higher MFHA assay sensitivity.

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High prevalence of co-infection between human papillomavirus (HPV) 51 and 52 in Mexican population

Cited by 29 publications

References 37 publications

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

A fluorometric hybridization assay for detecting and genotyping high-risk human papillomavirus 16 and 18 in archival tissues of cervical specimens

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