High phenolics and antioxidants of some tropical vegetables related to antibacterial and anticancer activities

Daduang, Jureerut

doi:10.5897/ajpp10.243

Cited by 38 publications

(23 citation statements)

References 25 publications

(27 reference statements)

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“…against oral cavity cells but not normal cells is suggestive of preventive roles in cancer (Daduang et al, 2011). This study also demonstrated that the active fractions from C mimosoides Lamk enhanced killing of high-risk HPVpositive and HPV-negative cells.…”

Section: 449 Cytotoxic Effects Of Phytophenolics From Caesalpinia MIsupporting

confidence: 49%

“…Several studies revealed that these phenolic compounds have some biological properties, such as anti-oxidant, anti-microbial and anti-cancer activities (Chanwitheesuk et al, 2007;Kim, 2007;Frampton et al, 2010;Lu et al, 2010;Daduang et al, 2011;Hahnvajanawong et al, 2011;Niknafs, 2011;Sakong et al, 2011;Kim and Lee, 2012). Caffeine is thought to increase the anti-tumor effect of cisplatin or DNA-damaging agents because caffeine inhibits DNA repair.…”

Section: 449 Cytotoxic Effects Of Phytophenolics From Caesalpinia MImentioning

confidence: 99%

“…Potential anti-inflammatory diterpenoids have been isolated from the roots of C mimosoides Lamk (Yodsaoue et al, 2010). Moreover, the cytotoxic effect of the methanolic crude extract from C mimosoides Lamk on oral cavity cell lines but not normal cells has been demonstrated, thereby suggesting a possible cancerpreventive role of C mimosoides Lamk (Daduang et al, 2011). There are few papers about the effect of bioactive compounds on cervical carcinoma cells.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic Effects of Phytophenolics from Caesalpinia mimosoides Lamk on Cervical Carcinoma Cell Lines through an Apoptotic Pathway

Palasap¹,

Limpaiboon²,

Boonsiri³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: 449 Cytotoxic Effects Of Phytophenolics From Caesalpinia MIsupporting

confidence: 49%

Section: 449 Cytotoxic Effects Of Phytophenolics From Caesalpinia MImentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytotoxic Effects of Phytophenolics from Caesalpinia mimosoides Lamk on Cervical Carcinoma Cell Lines through an Apoptotic Pathway

Palasap¹,

Limpaiboon²,

Boonsiri³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Total phenolic content of crude extracts were determined according to a modified method of Daduang et al (2011). All crude extracts were dissolved in 5%DMSO and final concentration was adjusted to 1 mg/mL.…”

Section: Determination Of Total Phenolic Content (Tpc)mentioning

confidence: 99%

Cytotoxicity of Cratoxylum Formosum Subsp. Pruniflorum Gogel Extracts in Oral Cancer Cell Lines

Promraksa

Daduang²,

Chaiyarit³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Oral cancer is a health problem in Thailand. Cratoxylum formosum subsp. pruniflorum Gogel (Teawdang), normally consumed in northeast Thailand, has proven cytotoxic to cervical cancer cell lines including HeLa, SiHa and C-33A. Recently, Asian oral cancer cell lines, ORL-48 and ORL-136, were established. Therefore, we aimed to study cytotoxicity of Teawdang in these. Total phenolic (TPC) and flavonoid content (TFC), and antioxidant activity of Teawdang were also determined. Materials and Methods: Teawdang was purchased from Khon Kaen market during June-October 2013. Hexane (CHE), ethyl acetate (CEE) and methanol (CME) extracts of its edible part were analyzed for TPC by the folin-ciocalteau method and for TFC by an aluminium colorimetric method. Antioxidant activity and cytotoxicity in normal Vero cells and oral cancer cells were investigated. Cell viability was assessed using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Results: CME and CEE had higher TPC and TFC and antioxidant activity than CHE. Both CME and CEE, at 200 µg dry wt/mL, were cytotoxic to the studied oral cancer cell lines. However, CME was cytotoxic to Vero cells whereas CEE was not. Compared to Vero cells, CEE significantly inhibited ORL-48 and ORL-136 growth (p=0.03 and p=0.02, respectively). Conclusions: CEE exhibited cytotoxic effects on the studied oral cancer cell lines but not normal Vero cells. The bioactive compounds in CEE should be further purified and elucidated for their mechanisms of action for development as anticancer agents.

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“…Some recent studies have assessed the phenolic content of various medicinal and food plants and their related antioxidant properties (e.g., Basar et al 2013;Choudhary and Swarnkar 2011;Daduang et al 2011;Haminiuk et al 2012, Maisuthisakul et al 2007. Though most studies showed a significant relationship between phenolic content and antioxidant properties in vitro, the actual bioavailability of phenolic compounds after digestion is uncertain (Manach et al 2004).…”

Section: Plant Phenolic Compoundsmentioning

confidence: 99%

Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies

Bullard-Roberts¹

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Thanks to my Ethnobotany sisters, Cassy Quave and Janna Rose, for making the path smoother and to the Koptur lab for adopting me when I had no lab family left.Thanks to Sasha, Asha and Xtina from the Jaffe and Berry Labs at BBC for sharing their space, equipment and expertise.Thanks to James and Kate at the Quave Lab at Emory University for helping me to navigate through failed trials and strange calculations. Diabetes mellitus (DM) is a group of non-infectious diseases that cause hyperglycemia. DM symptoms were first clinically described by ancient Greek physicians whose prescriptions included plant-based remedies. Today, DM affects >400 million people globally and prevalence rates are rapidly increasing in developing countries where basic healthcare relies on local knowledge of botanical remedies. Many developing countries are home to diverse peoples and plants-providing fodder for varied plant-selection strategies and unique botanical pharmacopoeias.I addressed the plant-selection strategies used in a multi-ethnic, developing country, Trinidad and Tobago (T&T), to ascertain their role in shaping the local antidiabetic pharmacopoeia and to assess their benefits and risks in identifying safe and useful remedies. Using literature reviews, field surveys, and laboratory bioassays, Icompleted three categories of analysis.Ethnobotanical analyses showed that T&T's antidiabetic pharmacopoeia is primarily of recent origin as >50% of the 48 historical DM remedies were Neotropical natives, including congenerics of well-known medicinal Paleotropical genera. ix Nevertheless, conservative knowledge transmission was also evident as several Paleotropical species of T&T's pharmacopoeia, including Momordica charantia and Catharanthus roseus were also used in Africa, India and across the Caribbean.Paleotropical natives with a long history of use are likely to be safer remedies.Ethno-medicinal analyses of the pre-and post-2000 DM remedies of T&T, totaling 99 species, suggest that the centuries-old hot/cold folk disease-model was the model predominantly used in plant-selection. Parallels found between T&T folk concepts and biomedical mechanisms of DM provide probable bases for efficacy but the chronic use of purgatives and bitter-tasting plants is likely to be risky.Phytochemical analyses revealed that 69% of the tested plant extracts contained phenolic compounds, with more than half producing >80% alpha-glucosidase inhibition.Phenolic content and alpha-glucosidase inhibition were strongly correlated among food plants used as medicines, suggesting higher probability of selection as a result of nontarget effects. The medicinal use of food plants may provide the best margins of safety and efficacy in identifying antidiabetic remedies.Together, these analyses showed how culture-specific plant-selection strategies can identify safe, useful remedies for developing countries to address their increasing DM prevalence in a cost-effective and sustainable manner.x Table 3 Regions of the Indian sub-continent from which indentured laborers...

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High phenolics and antioxidants of some tropical vegetables related to antibacterial and anticancer activities

Cited by 38 publications

References 25 publications

Cytotoxic Effects of Phytophenolics from Caesalpinia mimosoides Lamk on Cervical Carcinoma Cell Lines through an Apoptotic Pathway

Cytotoxic Effects of Phytophenolics from Caesalpinia mimosoides Lamk on Cervical Carcinoma Cell Lines through an Apoptotic Pathway

Cytotoxicity of Cratoxylum Formosum Subsp. Pruniflorum Gogel Extracts in Oral Cancer Cell Lines

Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies

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