Cytotoxic Effects of Phytophenolics from Caesalpinia mimosoides Lamk on Cervical Carcinoma Cell Lines through an Apoptotic Pathway

Palasap, Adisak; Limpaiboon, Temduang; Boonsiri, Patcharee; Thapphasaraphong, Suthasinee; Daduang, Sakda; Suwannalert, Prasit; Daduang, Jureerut

doi:10.7314/apjcp.2014.15.1.449

Cited by 25 publications

(18 citation statements)

References 23 publications

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“…Similarly other medicinal plant extracts have been shown to have significant anticancer activity in cervical cencer cell lines (Dwivedi et al, 2011;Palasap et al, 2014). Roy and Mukherjee (2014) recently demonstrated the reversal of resistance to cisplatin by adding curcumin in cisplatin resistance SiHa cervical cancer cell lines.…”

Section: Interleukin-6mentioning

confidence: 97%

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Paradkar¹,

Joshi²,

Mertia³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cytokine research is currently at the forefront in cancer research. Deciphering the functions of these multiple small molecules, discovered within the cell and in intercellular spaces, with their abundance and pleotrophism, was initially a great challenge. Advances in analytical chemistry and molecular biology have made it possible to unravel the pathophysiological functions of these polypeptides/proteins which are called interleukins, chemokines, monokines, lymphokines and growth factors. With more than 5 million women contracting cervical cancer every year this cancer is a major cause of mortality and morbidity the world over, particularly in the developing countries. In more than 95% of cases it is associated with human papilloma virus (HPV) infection which is persistent, particularly in those with a defective immune system. Although preventable, the mere magnitude of prevalence of HPV in the world population makes it a dominating current health hazard. The discovery of cytokine dysregulation in cervical cancer has spurted investigation into the possibility of using them as biomarkers in the early diagnosis of cases at high risk of developing cancer. Their critical role in carcinogenesis and progression of cervical cancer is now being revealed to a great extent. From diagnostics to prognosis, and now with a possible role in therapeutics and prevention of cervical cancer, the cytokines are being evaluated in all anticancer approaches. This review endeavours to capture the essence of the astonishing journey of cytokine research in cervical neoplasia.

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Section: Interleukin-6mentioning

confidence: 97%

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Paradkar¹,

Joshi²,

Mertia³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Examples of these are, ferulic acid 41 , artemisinin [42][43][44] , withaferin A 45 , resveratrol 46 , (-)-epigallocatechin-3-gallate 47 , ursolic acid 48 , berberine 49 , jaceosidin 50 , curcumin 51 and indole-3-carbinol 52 . Although all these products have shown activity against cultured HPV positive cervical carcinoma cell lines very few have been trialled in the clinic.…”

Section: Pre-clinical and Clinical Trials Carried Out On Natural Prodmentioning

confidence: 99%

An overview of early investigational drugs for the treatment of human papilloma virus infection and associated dysplasia

Hampson

Martin-Hirsch

Hampson

2015

Expert Opinion on Investigational Drugs

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Introduction: Infection with hHigh-risk types of HPV (HR-HPV) isare the main aetiological agent forcause of invasive cervical cancer (ICC) from which there are >270,000 deaths per annum world-wide with over 85% of these occurring in lowresource countries. Ablative and excisional treatment modalities are restricted for use with high-grade pre-cancerous cervical disease with HPV infection and low-grade dysplasia is currently managed by a watch-and-wait policy.

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“…Searching for natural products as the cure of cervix cancer is increasing due to the prevalence of non surgical approaches, however, finding various natural products with high curative properties is the main purpose of tremendous studies (Palasap et al, 2014). Many evidences proved that the peroxide and free radicals generated in the body are related with developing cancers and other degenerative pathologies, especially cervical carcinoma (Di Domenico et al, 2012).…”

Section: Introductionmentioning

confidence: 99%