High-penetration swept source Doppler optical coherence angiography by fully numerical phase stabilization

Hong, Young-Joo; Makita, Shuichi; Jaillon, Franck; Ju, Myeong Jin; Min, Eun Jung; Lee, Byeong Ha; Itoh, Masahide; Miura, Masahiro; Yasuno, Yoshiaki

doi:10.1364/oe.20.002740

Cited by 65 publications

(63 citation statements)

References 43 publications

(36 reference statements)

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“…Additionally, swept-source OCT has a larger Doppler dynamic range than spectraldomain OCT due to a higher fringe washout velocity and is thus suitable for measuring very fast flow speeds [13]. However, Doppler OCT requires good phase stability for quantifying slow flow velocities [13][14][15] and suffers from reduced sensitivity for small blood vessels [16,17]. Furthermore, the measured Doppler frequency shift in a blood vessel varies inversely with the cosine of the Doppler angle, or the angle between the incident beam and blood vessel [18].…”

Section: Introductionmentioning

confidence: 99%

Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Tokayer¹,

Jia²,

Dhalla³

et al. 2013

Biomed. Opt. Express

211

171

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Abstract:The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was recently developed as a method for imaging blood flow in the human retina without the use of phase information. In order to enable absolute blood velocity quantification, in vitro phantom experiments are performed to correlate the SSADA signal at multiple time scales with various preset velocities. A linear model relating SSADA measurements to absolute flow velocities is derived using the phantom data. The operating range for the linear model is discussed along with its implication for velocity quantification with SSADA in a clinical setting.

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Section: Introductionmentioning

confidence: 99%

Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Tokayer¹,

Jia²,

Dhalla³

et al. 2013

Biomed. Opt. Express

211

171

View full text Add to dashboard Cite

show abstract

“…Research grade systems developed for the imaging of the posterior segment of the eye can operate at imaging speeds of 100 ∼ 400 kHz with the use of short cavity swept source lasers. [11][12][13][14][15][16][17][18] Imaging speeds beyond 1 MHz can be achieved with Fourier-domain mode-locked (FDML) lasers. 18,19 Another technique enabling over 1-MHz imaging is full-field swept source OCT. 20 Advances in high-speed OCT imaging techniques enabled development of OCT velocimetry (OCT-V) and OCTA methods.…”

Section: Introductionmentioning

confidence: 99%

Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate

et al. 2017

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Iwona Gorczynska, "Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate," J. Biomed. Opt. Abstract. We present noninvasive, three-dimensional, depth-resolved imaging of human retinal and choroidal blood circulation with a swept-source optical coherence tomography (OCT) system at 1065-nm center wavelength. Motion contrast OCT imaging was performed with the phase-variance OCT angiography method. A Fourier-domain mode-locked light source was used to enable an imaging rate of 1.7 MHz. We experimentally demonstrate the challenges and advantages of wide-field OCT angiography (OCTA). In the discussion, we consider acquisition time, scanning area, scanning density, and their influence on visualization of selected features of the retinal and choroidal vascular networks. The OCTA imaging was performed with a field of view of 16 deg (5 mm × 5 mm) and 30 deg (9 mm × 9 mm). Data were presented in en face projections generated from single volumes and in en face projection mosaics generated from up to 4 datasets. OCTA imaging at 1.7 MHz A-scan rate was compared with results obtained from a commercial OCTA instrument and with conventional ophthalmic diagnostic methods: fundus photography, fluorescein, and indocyanine green angiography. Comparison of images obtained from all methods is demonstrated using the same eye of a healthy volunteer. For example, imaging of retinal pathology is presented in three cases of advanced age-related macular degeneration. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…A few numerical methods have been proposed to improve the phase stability of SS-OCT systems [3][4][5][6][7]. However, to the best of our knowledge, removal of the residual fixed-pattern noise with these methods has not been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Postprocessing algorithms to minimize fixed-pattern artifact and reduce trigger jitter in swept source optical coherence tomography

Liu¹,

Tan²,

Gao³

et al. 2015

Opt. Express

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Abstract:We propose methods to align interferograms affected by trigger jitter to a reference interferogram based on the information (amplitude/phase) at a fixed-pattern noise location to reduce residual fixedpattern noise and improve the phase stability of swept source optical coherence tomography (SS-OCT) systems. One proposed method achieved this by introducing a wavenumber shift (k-shift) in the interferograms of interest and searching for the k-shift that minimized the fixed-pattern noise amplitude. The other method calculated the relative k-shift using the phase information at the residual fixed-pattern noise location. Repeating this wavenumber alignment procedure for all A-lines of interest produced fixedpattern noise free and phase stable OCT images. A system incorporating these correction routines was used for human retina OCT and Doppler OCT imaging. The results from the two methods were compared, and it was found that the intensity-based method provided better results. Duker, and J. G. Fujimoto, "Phase-sensitive swept-source optical coherence tomography imaging of the human retina with a vertical cavity surface-emitting laser light source," Opt. Lett. 38(3), 338-340 (2013).

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High-penetration swept source Doppler optical coherence angiography by fully numerical phase stabilization

Cited by 65 publications

References 43 publications

Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate

Postprocessing algorithms to minimize fixed-pattern artifact and reduce trigger jitter in swept source optical coherence tomography

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