Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Tokayer, Jason; Jia, Yali; Dhalla, Al Hafeez; Huang, David

doi:10.1364/boe.4.001909

Cited by 213 publications

(178 citation statements)

References 54 publications

Supporting

Mentioning

171

Contrasting

Unclassified

Order By: Relevance

“…6 These are rendered as two-dimensional en face maps in which the pixel brightness represents blood flow. 7 The relative absence of stationary or time-static structures from OCT-A maps distinguishes these images from those rendered by conventional en face OCT.…”

Section: Discussionmentioning

confidence: 99%

En face OCT angiography demonstrates flow in early type 3 neovascularization (retinal angiomatous proliferation)

Dansingani

Naysan

Freund

2015

Eye

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

En face OCT angiography demonstrates flow in early type 3 neovascularization (retinal angiomatous proliferation)

Dansingani

Naysan

Freund

2015

Eye

View full text Add to dashboard Cite

“…Because the optics of the OCT probe were designed to be used while immersed in water, we expect to have a small defocus which modifies w t in Eq. (20), and therefore k in Eq. (22).…”

Section: Resultsmentioning

confidence: 99%

“…Few studies have addressed quantitation from speckle decorrelation measurements [17,18,19], and we are unaware of studies validating quantitative speckle analysis. A recent report acknowledged this lack of validation and discussed the work needed to bring a particular implementation of speckle decorrelation, split-spectrum angiography, into the realm of quantitative flow measurements [20]. Despite their advances, however, the authors recognized that more insight was needed in order to realize this goal.…”

Section: Introductionmentioning

confidence: 99%

Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography

2014

View full text Add to dashboard Cite

Abstract:Intensity-based techniques in optical coherence tomography (OCT), such as those based on speckle decorrelation, have attracted great interest for biomedical and industrial applications requiring speed or flow information. In this work we present a rigorous analysis of the effects of noise on speckle decorrelation, demonstrate that these effects frustrate accurate speed quantitation, and propose new techniques that achieve quantitative and repeatable measurements. First, we derive the effect of background noise on the speckle autocorrelation function, finding two detrimental effects of noise. We propose a new autocorrelation function that is immune to the main effect of background noise and permits quantitative measurements at high and moderate signal-to-noise ratios. At the same time, this autocorrelation function is able to provide motion contrast information that accurately identifies areas with movement, similar to speckle variance techniques. In order to extend the SNR range, we quantify and model the second effect of background noise on the autocorrelation function through a calibration. By obtaining an explicit expression for the decorrelation time as a function of speed and diffusion, we show how to use our autocorrelation function and noise calibration to measure a flowing liquid. We obtain accurate results, which are validated by Doppler OCT, and demonstrate a very high dynamic range (> 600 mm/s) compared to that of Doppler OCT (±25 mm/s). We also derive the behavior for low flows, and show that there is an inherent non-linearity in speed measurements in the presence of diffusion due to statistical fluctuations of speckle. Our technique allows quantitative and robust measurements of speeds using OCT, and this work delimits precisely the conditions in which it is accurate.

show abstract

“…Существует также возможность получать по-слойные карты плотности сосудов сетчатки с поква-дрантным расчетом значений плотности сосудов. В-сканы ОКТ могут регистрироваться одновремен-но с ОКТ-ангиограммами, поэтому можно увидеть точное местоположение патологического участка на соответствующих В-сканах [22,23]. Достоинством ОКТ-А является возможность визуализации как ре-тинальной, так и хориоидальной микрососудистой сети, тогда как ФАГ позволяет "видеть" только со-суды сетчатки, а ИЦЗА больше подходит для иссле-дования сосудистой оболочки.…”

Section: окт-ангиография (окт-а)unclassified

Optical coherence tomography angiography in glaucoma diagnosis

Kurysheva

Маслова

2016

Vestn. oftal'mol.

View full text Add to dashboard Cite

Оптическая когерентная томография с функцией ангиографии в диагностике глаукомы Н.И. курыШеВА, е.В. МАСлоВА ФГБоу ДПо «Институт повышения квалификации» ФМБА, ул. Гамалеи, 15, Москва, 123098, российская Федерация Данные литературы свидетельствуют o вовлечении сосудистой дисфункции в патогенез глаукомной оптиконейропатии. Это делает обоснованным поиск новых методов визуализации для ранней диагностики и мониторинга глаукомы, направленных на изучение перфузии сетчатки, зрительного нерва и хориоидеи. Появившийся недавно метод оптической когерентной томографии с функцией ангиографии (окТ-А), основанный на измерении степени декорреляции последовательных по времени B-сканов (split-spectrum amplitude-decorrelation angiography, SSADA), позволяет измерить кровоток сетчатки и хориоидеи как в перипапиллярной, так и макулярной зонах. результаты первых исследований методом окТ-А показали снижение кровотока при глаукоме. Периметрические индексы лучше коррелируют с индексом перипапиллярного кровотока, чем с морфометрическими показателями диска зрительного нерва (ДЗН) и перипапиллярной сетчатки. окТ-А имеет большие перспективы в исследовании кровотока ДЗН при проведении физиологических тестов, что важно для понимания патогенеза глаукомы. According to literature data, vascular dysfunction may well contribute to the development of glaucomatous optic neuropathy, which makes it reasonable to search for new imaging techniques capable of early diagnosis and monitoring of glaucoma through assessment of retinal, optic nerve head (ONH), and choroidal perfusion. Optical coherence tomography angiography (OCTA), a recently introduced method based on the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm, enables evaluation of both retinal and choroidal blood flow in peripapillary and macular areas. The first studies involving OCTA have revealed a decrease in retinal blood flow in glaucoma. It has also been shown that visual field indices correlate better with the peripapillary flow index than with morphometric parameters of the optic nerve head (ONH) and peripapillary retina. OCT angiography has great potential for ONH blood flow assessment during physiological tests, which is an important step towards understanding pathogenesis of glaucoma.

show abstract

Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Cited by 213 publications

References 54 publications

En face OCT angiography demonstrates flow in early type 3 neovascularization (retinal angiomatous proliferation)

En face OCT angiography demonstrates flow in early type 3 neovascularization (retinal angiomatous proliferation)

Quantitative technique for robust and noise-tolerant speed measurements based on speckle decorrelation in optical coherence tomography

Optical coherence tomography angiography in glaucoma diagnosis

Contact Info

Product

Resources

About